University of Medicine and Dentistry of New Jersey

About: University of Medicine and Dentistry of New Jersey is a based out in . It is known for research contribution in the topics: Population & Poison control. The organization has 14634 authors who have published 19610 publications receiving 1041794 citations.

Autophagy and metabolism.

Abstract: Autophagy is a process of self-cannibalization Cells capture their own cytoplasm and organelles and consume them in lysosomes The resulting breakdown products are inputs to cellular metabolism, through which they are used to generate energy and to build new proteins and membranes Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones In starvation, it provides an internal source of nutrients for energy generation and, thus, survival A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases It does have a downside, however—cancer cells exploit it to survive in nutrient-poor tumors

An analysis of vertebrate mRNA sequences: intimations of translational control.

Abstract: Five structural features in mRNAs have been found to contribute to the fidelity and efficiency of initiation by eukaryotic ribosomes. Scrutiny of vertebrate cDNA sequences in light of these criteria reveals a set of transcripts--encoding oncoproteins, growth factors, transcription factors, and other regulatory proteins--that seem designed to be translated poorly. Thus, throttling at the level of translation may be a critical component of gene regulation in vertebrates. An alternative interpretation is that some (perhaps many) cDNAs with encumbered 5' noncoding sequences represent mRNA precursors, which would imply extensive regulation at a posttranscriptional step that precedes translation.