Institution
University of Medicine and Dentistry of New Jersey
Education•
About: University of Medicine and Dentistry of New Jersey is a based out in . It is known for research contribution in the topics: Population & Poison control. The organization has 14634 authors who have published 19610 publications receiving 1041794 citations.
Topics: Population, Poison control, Pregnancy, Health care, Gene
Papers published on a yearly basis
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TL;DR: A method to obtain telomere length parameters using Southern blots of terminal restriction fragments (TRFs) is described, which requires a considerable amount of DNA and measures both the canonical and noncanonical components of telomeres.
Abstract: In this protocol we describe a method to obtain telomere length parameters using Southern blots of terminal restriction fragments (TRFs). We use this approach primarily for epidemiological studies that examine leukocyte telomere length. However, the method can be adapted for telomere length measurements in other cells whose telomere lengths are within its detection boundaries. After extraction, DNA is inspected for integrity, digested, resolved by gel electrophoresis, transferred to a membrane, hybridized with labeled probes and exposed to X-ray film using chemiluminescence. Although precise and highly accurate, the method requires a considerable amount of DNA (3 μg per sample) and it measures both the canonical and noncanonical components of telomeres. The method also provides parameters of telomere length distribution in each DNA sample, which are useful in answering questions beyond those focusing on the mean length of telomeres in a given sample. A skilled technician can measure TRF length in ∼130 samples per week.
393 citations
TL;DR: Diabetes mellitus is an important risk factor for mortality and morbidity among those undergoing CABG and research is needed to determine if good control of glucose levels during the perioperative time period improves outcome.
392 citations
TL;DR: Facing the overlap of traditional, modern, and emerging environmental dilemmas, China has committed substantial resources to environmental improvement and has the opportunity to address its national environmental health challenges and to assume a central role in the international effort to improve the global environment.
391 citations
TL;DR: The results of this first randomized controlled study of DBS for the treatment of TRD did not demonstrate a significant difference in response rates between the active and control groups at the end of the 16-week controlled phase.
390 citations
TL;DR: Data indicate that paraoxonase, an organophosphate-detoxifying enzyme whose natural substrate and function remained unknown up to now, is in fact homocysteine thiolactonase.
390 citations
Authors
Showing all 14639 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| John Q. Trojanowski | 226 | 1467 | 213948 |
| Virginia M.-Y. Lee | 194 | 993 | 148820 |
| Danny Reinberg | 145 | 342 | 68201 |
| Michael F. Holick | 145 | 767 | 107937 |
| Tasuku Honjo | 141 | 712 | 88428 |
| Arnold J. Levine | 139 | 485 | 116005 |
| Aaron T. Beck | 139 | 536 | 170816 |
| Charles J. Yeo | 136 | 672 | 76424 |
| Jerry W. Shay | 133 | 639 | 74774 |
| Chung S. Yang | 128 | 560 | 56265 |
| Paul G. Falkowski | 127 | 378 | 64898 |
| Csaba Szabó | 123 | 958 | 61791 |
| William C. Roberts | 122 | 1117 | 55285 |
| Bryan R. Cullen | 121 | 371 | 50901 |
| John R. Perfect | 119 | 573 | 52325 |