Institution
University of Memphis
Education•Memphis, Tennessee, United States•
About: University of Memphis is a education organization based out in Memphis, Tennessee, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 7710 authors who have published 20082 publications receiving 611618 citations. The organization is also known as: U of M.
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors report quantitative tumor uptake studies for a class of elongated gold nanocrystals (called nanorods) that are covalently conjugated to tumor-targeting peptides.
Abstract: The targeted delivery of nanoparticles to solid tumors is one of the most important and challenging problems in cancer nanomedicine, but the detailed delivery mechanisms and design principles are still not well understood. Here we report quantitative tumor uptake studies for a class of elongated gold nanocrystals (called nanorods) that are covalently conjugated to tumor-targeting peptides. A major advantage in using gold as a “tracer” is that the accumulated gold in tumors and other organs can be quantitatively determined by elemental mass spectrometry (gold is not a natural element found in animals). Thus, colloidal gold nanorods are stabilized with a layer of polyethylene glycols (PEGs), and are conjugated to three different ligands: (i) a single-chain variable fragment (ScFv) peptide that recognizes the epidermal growth factor receptor (EGFR); (ii) an amino terminal fragment (ATF) peptide that recognizes the urokinase plasminogen activator receptor (uPAR); and (iii) a cyclic RGD peptide that recognizes the avb3 integrin receptor. Quantitative pharmacokinetic and biodistribution data show that these targeting ligands only marginally improve the total gold accumulation in xenograft tumor models in comparison with nontargeted controls, but their use could greatly alter the intracellular and extracellular nanoparticle distributions. When the gold nanorods are administered via intravenous injection, we also find that active molecular targeting of the tumor microenvironments (e.g., fibroblasts, macrophages, and vasculatures) does not significantly influence the tumor nanoparticle uptake. These results suggest that for photothermal cancer therapy, the preferred route of gold nanorod administration is intra-tumoral injection instead of intravenous injection.
421 citations
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TL;DR: In this article, the authors argue that firms that can lower their costs and enhance their differentiation through the effective management of their human resources have a competitive advantage, using data from the U.S. Department of Defense.
Abstract: This study's premise is that firms that can lower their costs and enhance their differentiation through the effective management of their human resources have a competitive advantage. Using data fr...
420 citations
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TL;DR: In this article, the authors present a profile of financial statement fraud by reviewing a selective sample of financial statements fraud cases and demonstrate that "cooking the books" is a crime and results in a crime.
419 citations
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University of Memphis1, Harvard University2, University of Arizona3, University of Texas at Austin4, Oregon State University5, California Department of Food and Agriculture6, University of Jena7, Clemson University8, University of California, Riverside9, Montana State University10, Wichita State University11, Landcare Research12, National University of La Plata13, University of Georgia14, Field Museum of Natural History15, Brigham Young University16, Commonwealth Scientific and Industrial Research Organisation17
TL;DR: A phylogeny of beetles based on DNA sequence data from eight nuclear genes, including six single‐copy nuclear protein‐coding genes, for 367 species representing 172 of 183 extant families provides a uniquely well‐resolved temporal and phylogenetic framework for studying patterns of innovation and diversification in Coleoptera.
Abstract: © 2015 The Authors. Systematic Entomology published by John Wiley & Sons Ltd on behalf of Royal Entomological Society
This is an open access article under the terms of the Creative Commons AttributionߚNonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
419 citations
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TL;DR: This work has dissected the discourse and pedagogical strategies these unskilled tutors exhibit by analyzing approximately 100 hours of naturalistic tutoring sessions.
418 citations
Authors
Showing all 7827 results
Name | H-index | Papers | Citations |
---|---|---|---|
James F. Sallis | 169 | 825 | 144836 |
Robert G. Webster | 158 | 843 | 90776 |
Ching-Hon Pui | 145 | 805 | 72146 |
James Whelan | 128 | 786 | 89180 |
Tom Baranowski | 103 | 485 | 36327 |
Peter C. Doherty | 101 | 516 | 40162 |
Jian Chen | 96 | 1718 | 52917 |
Arthur C. Graesser | 95 | 614 | 38549 |
David Richards | 95 | 578 | 47107 |
Jianhong Wu | 93 | 726 | 36427 |
Richard W. Compans | 91 | 526 | 31576 |
Shiriki K. Kumanyika | 90 | 349 | 44959 |
Alexander J. Blake | 89 | 1133 | 35746 |
Marek Czosnyka | 88 | 747 | 29117 |
David M. Murray | 86 | 300 | 21500 |