University of Memphis

About: University of Memphis is a education organization based out in Memphis, Tennessee, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 7710 authors who have published 20082 publications receiving 611618 citations. The organization is also known as: U of M.

Attachment in Adult Romantic Relationships: Style of Conflict Resolution and Relationship Satisfaction

Abstract: This study considers the issue of adult attachment style in relation to conflict resolution and relationship satisfaction. Subjects selected into one of three styles: secure, anxious/ambivalent, or avoidant. Analyses revealed significant differences among the groups on three styles of conflict resolution (compromising, obliging, and integrating) and on relationship satisfaction. The results are interpreted with regard to attachment theory.

Using 1-Hz GPS data to measure deformations caused by the denali fault earthquake

Abstract: The 3 November 2002 moment magnitude 7.9 Denali fault earthquake generated large, permanent surface displacements in Alaska and large-amplitude surface waves throughout western North America. We find good agreement between strong ground-motion records integrated to displacement and 1-hertz Global Positioning System (GPS) position estimates collected ∼140 kilometers from the earthquake epicenter. One-hertz GPS receivers also detected seismic surface waves 750 to 3800 kilometers from the epicenter, whereas these waves saturated many of the seismicinstruments in the same region. High-frequency GPS increases the dynamic range and frequency bandwidth of ground-motion observations, providing another tool for studying earthquake processes.

The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans.

Abstract: Constitutive overexpression of the MDR1 (multidrug resistance) gene, which encodes a multidrug efflux pump of the major facilitator superfamily, is a frequent cause of resistance to fluconazole and other toxic compounds in clinical Candida albicans strains, but the mechanism of MDR1 upregulation has not been resolved. By genome-wide gene expression analysis we have identified a zinc cluster transcription factor, designated as MRR1 (multidrug resistance regulator), that was coordinately upregulated with MDR1 in drug-resistant, clinical C. albicans isolates. Inactivation of MRR1 in two such drug-resistant isolates abolished both MDR1 expression and multidrug resistance. Sequence analysis of the MRR1 alleles of two matched drug-sensitive and drug-resistant C. albicans isolate pairs showed that the resistant isolates had become homozygous for MRR1 alleles that contained single nucleotide substitutions, resulting in a P683S exchange in one isolate and a G997V substitution in the other isolate. Introduction of these mutated alleles into a drug-susceptible C. albicans strain resulted in constitutive MDR1 overexpression and multidrug resistance. By comparing the transcriptional profiles of drug-resistant C. albicans isolates and mrr1Δ mutants derived from them and of C. albicans strains carrying wild-type and mutated MRR1 alleles, we defined the target genes that are controlled by Mrr1p. Many of the Mrr1p target genes encode oxidoreductases, whose upregulation in fluconazole-resistant isolates may help to prevent cell damage resulting from the generation of toxic molecules in the presence of fluconazole and thereby contribute to drug resistance. The identification of MRR1 as the central regulator of the MDR1 efflux pump and the elucidation of the mutations that have occurred in fluconazole-resistant, clinical C. albicans isolates and result in constitutive activity of this trancription factor provide detailed insights into the molecular basis of multidrug resistance in this important human fungal pathogen.