Showing papers by "University of Miami published in 1981"
TL;DR: One‐hundred‐ninety‐four eligible and evaluable patients with histologically confirmed locally unresectable adenocarcinoma of the pancreas were randomly assigned to therapy with high‐dose radiation therapy alone, to moderate‐dose (4000 rads) radiation + 5‐fluorouracil (5‐FU), and to high‐ dose radiation plus 5‐FU.
Abstract: One-hundred-ninety-four eligible and evaluable patients with histologically confirmed locally unresectable adenocarcinoma of the pancreas were randomly assigned to therapy with high-dose (6000 rads) radiation therapy alone, to moderate-dose (4000 rads) radiation + 5-fluorouracil (5-FU), and to high-dose radiation plus 5-FU. Median survival with radiation alone was only 51/2 months from date of diagnosis. Both 5-FU-containing treatment regimens produced a highly significant survival improvement when compared with radiation alone. Forty percent of patients treated with the combined regimens were still living at one year compared with 10% of patients treated with radiation only. Survival differences between 4000 rads plus 5-FU and 6000 rads plus 5-FU were not significant with an overall median survival of ten months. Significant prognostic variables, in addition to treatment, were pretreatment performance status and pretreatment CEA level.
999 citations
TL;DR: In the early Holocene, when sea level rose at rates of 6,000 to 10,000 µm/yr (= mm/1,000 yr), most reefs and platforms were outpaced by the rising sea as discussed by the authors.
Abstract: Shallow-water carbonate platforms and reefs are drowned when tectonic subsidence or rising sea level outpaces carbonate accumulation, and benthonic carbonate production ceases. Drowned platforms are common in the geologic record, but they present a paradox if one considers rates of processes involved. During the early Holocene, when sea level rose at rates of 6,000 to 10,000 µm/yr (= mm/1,000 yr), most reefs and platforms were outpaced by the rising sea. During the late Holocene with sea level rising 500 to 3,000 µm/yr in the Atlantic-Caribbean area, reefs and platforms started to recover, built to sea level, and prograded seaward, 1,000 µm/yr is thus a conservative estimate of the average growth potential of modern reefs and platforms. Independently, accumulation rates of prograding platforms in the geologic record suggest growth potential in excess of several hundred microns per year. The growth potential of 1,000 µm/yr exceeds any relative rise of sea level caused by long-term processes in the geologic record. Newly formed ocean crust subsides at a maximum of 250 µm/yr, basin subsidence averages 10 to 100 µm/yr, and sea level rises due to increased sea-floor spreading amount to less than 10 µm/yr. Rapid pulses of relative rise of sea level or reduction of benthic growth by deterioration of the environment remain the only plausible explanations of drowning. The geologic record shows examples of both of these processes. Global mass extinctions of reefs and platforms occurred in the middle Cretaceous (eustatic rise due to submarine volcanism or desiccation of a small ocean basin?) and the Late Devonian (global crisis of ocean environment, extraterrestrial cause?). Drowning controlled by regional tectonics prevailed in the Jurassic and Early Cretaceous of the Tethyan realm, and the drowning of Mesozoic platforms in the western North Atlantic seems to have been dictated by plate-tectonic drift to higher latitudes.
694 citations
01 Jun 1981
TL;DR: In this article, the authors proposed a new 1-atm equation of state for seawater that has been suggested for use by the United Nations Educational, Scientific and Cultural Organization (UNESCO) joint panel on oceanographic tables and standards.
Abstract: The density measurements by Millero, Gonzalez and Ward (1976, Journal of Marine Research,34, 61–93) and Poisson, Brunet and Brun-Cottan (1980, Deep-Sea Research, 27, 1013–1028), from 0 to 40°C and 0.5 to 43 salinity, have been used to determine a new 1-atm equation of state for seawater. The equation is of the form (t°C; S; ϱ kg m−3) ρ=ρ 0 +AS+BS 3 2 +CS , where A=8.24493×10 −1 −4.0899×10 −3 t+7.6438×10 −5 t 2 −8.2467×10 −7 t 3 +5.3875×10 −9 t 4 B=−5.72466×10 −3 +1.0227×10 −4 t−1.6546×10 −6 t 2 C=4.8314×10 −4 and ϱ0 is the density of water ( Bigg , 1967, British Journal of Applied Physics, 8, 521–537). ρ 0 =999.842594+6.793952×10 −2 t−9.095290× −3 t 2 +1.001685×10 −4 t 3 −1.120083×10 −6 t 4 +6.536336×10 −9 t 5 . The standard error of the equation is 3.6 × 10−3 kg m−3. This equation will become the new 1-atm equation of state of seawater that has been suggested for use by the UNESCO (United Nations Educational, Scientific and Cultural Organization) joint panel on oceanographic tables and standards.
599 citations
TL;DR: The results from an aerosol sampling station at Cayenne, French Guiana, which indicate that large quantities of soil dust are being carried out of North Africa and across the Atlantic during the winter months as well but at this time of year the transport is primarily to South America.
Abstract: The arid and desert regions of North Africa are a prolific source of atmospheric dust. This dust is, for example, responsible for the ‘red snows’ reported in the Alps and Pyrenees1 and for dust falls further north in Europe2–6, but these phenomena are infrequent and sporadic. By contrast, the transport of mineral dust into the tropical North Atlantic is common and often produces a widespread dense haze7. Investigations in the past 15 yr8–11 have shown that, in the summer months12,13, the distribution of dust is related to macro and micro-meteorological circumstances, that the dust often reaches altitudes of 5–7 km and that it may be spread over several hundreds of kilometres in latitude and extend to the Caribbean Sea and the south-east United States. We report here the results from an aerosol sampling station at Cayenne, French Guiana, which indicate that large quantities of soil dust are being carried out of North Africa and across the Atlantic during the winter months as well but at this time of year the transport is primarily to South America.
532 citations
TL;DR: The results indicate that the normalized inherent sea surface spectral radiance is constant to within ~10% for Morel's Case 1 waters as long as the phytoplankton pigment concentration does not exceed 0.25 mg/m(3).
Abstract: The possibility of computing the inherent sea surface radiance for regions of clear water from coastal zone color scanner (CZCS) imagery given only a knowledge of the local solar zenith angle is examined. The inherent sea surface radiance is related to the upwelling and downwelling irradiances just beneath the sea surface, and an expression is obtained for a normalized inherent sea surface radiance which is nearly independent of solar zenith angle for low phytoplankton pigment concentrations. An analysis of a data base consisting of vertical profiles of upwelled spectral radiance and pigment concentration, which was used in the development of the CZCS program, confirms the virtual constancy of the normalized inherent sea surface radiance at wavelengths of 520 and 550 nm for cases when the pigment concentration is less than 0.25 mg/cu m. A strategy is then developed for using the normalized inherent sea surface radiance in the atmospheric correction of CZCS imagery.
443 citations
TL;DR: The extracellular patch clamp technique is used to record the currents from patches of intact and isolated plasma cell membrane from rat myotubes and observe single channel currents that would give rise to Ca2+-activated K+ conductance, which is highly selective to K+ and has a conductance near 100 pS at physiological [K+].
Abstract: Many nerve and muscle cells possess a Ca2+-activated K+ conductance which gives rise to a long-lasting hyperpolarization following Ca2+ entry during an action potential and which appears different from the classical Hodgkin and Huxley voltage-activated K+ conductance1–7. Using the extracellular patch clamp technique8–12 to record the currents from patches of intact and isolated plasma cell membrane from rat myotubes, we have observed single channel currents that would give rise to this Ca2+-activated K+ conductance. The channels are highly selective to K+ and have a conductance near 100 pS at physiological [K+], a value 10–20 times greater than that of the classical voltage-activated K+ channels. The frequency with which these channels open and effective open times are controlled in a reversible manner by the free [Ca2+] on the intracellular side of the membrane; the channel seldom opens when the [Ca2+]i is <10−8 M, but opens with increasing frequency as the [Ca2+]i exceeds 5 × 10−7 M. With 0.5 µM Ca2+i both opening frequency and effective open times depend on membrane potential, increasing as the intracellular side of the membrane is made more positive. At higher levels of Ca2+i (50 µM), the channel is almost continuously active, even at hyperpolarized membrane potentials.
408 citations
TL;DR: This is the first immununohistochemical marker for prostate gland epithelium which does not represent prostatic acid phosphatase and is likely to be a diagnostic histologic marker for tumors of prostatic origin.
Abstract: Antiserum to a human prostate-specific antigen was raised in a rabbit and utilized by immunoperoxidase staining to evaluate its potential value as a diagnostic histologic marker for tumors of prostatic origin. All primary and metastatic prostatic malignancies reacted positively, whereas nonprostatic neoplasms did not stain with this procedure. This is the first immunohistochemical marker for prostate gland epithelium which does not represent prostatic acid phosphatase.
358 citations
TL;DR: In this paper, self-directed attention leads to the engagement of a cybernetic feedback loop, by which discrepancies between present behavior and a standard of comparison are reduced, which is applied to performance facilitation effects, which are more typically explained in terms of drive theories.
296 citations
TL;DR: The data on three criteria employed in this study provide evidence for the existence of two independent Ca2+ pathways, one for each mode of activation, for Ca2- influx known to be associated with these contractions.
Abstract: The activation of rabbit aortic smooth muscle was studied by two most widely used vascular smooth muscle stimulants: α-adrenoceptor activation by norepinephrine (NE) and high-K+ depolarization. This was studied by measurements of isometric contractions and net as well as unidirectional Ca2+ fluxes. These parameters showed markedly differential sensitivities towards two smooth muscle inhibitors used in this study: D 600 and amrinone. By choosing an appropriate concentration of D 600 or amrinone, Ca2+ uptake or Ca2+ influx induced by high K+ or NE could be selectively inhibited. Furthermore, by using unidirectional flux measurements it was demonstrated that Ca2+ influx stimulated by NE and high K+ were additive in nature. The data from the addivity experiment exclude the interpretation of a common Ca2+ pathway with two separate mechanisms for opening it. The data on three criteria employed in this study provide evidence for the existence of two independent Ca2+ pathways, one for each mode of activation, for Ca2+ influx known to be associated with these contractions.
278 citations
TL;DR: In an attempt to define guidelines for the assessment of acute asthma, 205 patients who presented to the emergency room for treatment of asthma were evaluated and a predictive index using a combination of presenting factors was developed, predicting the risk of relapse and the need for hospitalization.
Abstract: In an attempt to define guidelines for the assessment of acute asthma, we evaluated 205 patients who presented to the emergency room for treatment of asthma. Of the 205, 120 were successfully treated and discharged from the emergency room, 45 were hospitalized, and 40 were treated and discharged from the emergency room but had relapses within 10 days. A predictive index using a combination of presenting factors was developed: pulse rate ≥120 per minute, respiratory rate ≥30 per minute, pulsus paradoxus ≥18 mm Hg, peak expiratory flow rate ≤120 liters per minute, moderate to severe dyspnea, accessory-muscle use, and wheezing. The index ranged from 0 to 7, increasing with the severity of symptoms. The index scores of the relapse group (4.9±1.0) and the admitted group (5.1±1.0) were both significantly different (P<0.001) from that of the successfully treated group (1.6±1.2). An index of 4 or higher was 95 per cent accurate in predicting the risk of relapse and 96 per cent accurate in predicting the ...
271 citations
01 Jan 1981
TL;DR: Here, the thoughtful worker often encounters a most elusive concept since “communication” means quite different things to different people.
Abstract: A most intriguing aspect of social behavior is that eventually the topic of communication must be addressed. This is understandable because specific acts performed by one individual often alter the likelihood that specific acts will be performed by another. An appropriate question then arises: Did such a performance involve communication? Here, the thoughtful worker often encounters a most elusive concept since “communication” means quite different things to different people.
TL;DR: In this paper, an ocean circulation model, developed for the study of mesoscale to gyre-scale circulation and heat transport, is described and tested for a double-gyre ocean basin of the type used by Holland (1978).
Abstract: An ocean circulation model, developed for the study of mesoscale to gyre-scale circulation and heat transport, is described and tested. The model employs density as vertical coordinate except in the immediate vicinity of possible coordinate surface intersections with the ocean surface. Test simulations are carried out for a double-gyre ocean basin of the type used by Holland (1978), but with better resolution in the upper 1000 m of the model ocean. The final state of a 5-year coarse-mesh (50 km resolution on a 2400 km × 1200 km domain) spin-up is used as the initial state for mesoscale experimentation on a 25 km mesh. Basin energetics, as well as mean mass transport streamfunction and mean potential vorticity fields are given for three mesoscale experiments, in which the magnitude and formulation of lateral dissipation are varied. Each of these experiments, run for approximately five years, exhibits vigorous mesoscale activity associated with western boundary current separation and the free jet. ...
01 Apr 1981
TL;DR: In this paper, the effect of Gulf Stream frontal disturbances on low-frequency current and temperature variability, water exchange, and nutrient flux in the outer region of the Georgia shelf was analyzed using satellite, hydrographic and data from moored current meters.
Abstract: Satellite, hydrographic, and data from moored current meters are used to show the effect of Gulf Stream frontal disturbances on low-frequency current and temperature variability, water exchange, and nutrient flux in the outer region of the Georgia shelf. Perturbations of the Gulf Stream cyclonic front are commonly observed as folded wave patterns in routine satellite-derived analyses of the western boundary of the Gulf Stream between Cape Hatteras and Miami. The disturbances consist of southward-flowing warm filaments or streamers of near-surface Gulf Stream water, 15 to 20 m deep, which can extend 35 to 40 km over the outer shelf around a cold upwelled core. Downstream dimensions of the filaments reach 100 to 200 km in the region from Jupiter, Florida, to Charleston, South Carolina, 10 to 50 km south of Jupiter, and 200 to 300 km between Charleston and Cape Hatteras. The features are defined as cyclonic, cold-core frontal eddies due to their flow and water mass properties. They appear to form from amplified waves in the Gulf Stream cyclonic front on an annual average of one every two weeks but with considerable monthly variability. They can persist up to three weeks and travel to the north with the same phase speed as the waves, approx. 40 cm s−1. The cyclonic circulation in frontal eddies provides a means for rapid shelf-Gulf Stream water exchange. The eddies appear to control the residence time of the outer shelf waters, defined as the mean separation time between eddy events, or approx. two weeks. Upwelling in the cold core extended into the euphotic zone (45 m) and shoreward (35 to 40 km) beneath the southward-flowing warm filament in a bottom intrusion layer 20 m thick. The annual nitrogen input to the shelf waters by this process is estimated as 55,000 tons each year, about twice all other estimated nitrogen sources combined; it can support an annual carbon production by phytoplankton of 32 to 64 g C m−2y−1 with no nitrogen recycling.
TL;DR: An approach by which patient-determined blood glucose measurements may be used to attain and maintain glycemic control is described, provided with a set of algorithms by which minor adjustments in a therapeutic routine may be made to achieve the desired control.
Abstract: Patient self-monitoring of blood glucose is a useful adjuvant to diabetes therapy that facilitates improved glycemic control when used as part of an intensive diabetes management program that includes careful balancing of food intake, energy expenditure, and insulin dosage. This paper describes an approach by which patient-determined blood glucose measurements may be used to attain and maintain glycemic control. The patient is provided with a set of algorithms by which minor adjustments in a therapeutic routine may be made to achieve the desired control.
TL;DR: 11 overweight men who had the floppy eyelid syndrome, a disorder of unknown origin manifested by an easily everted, floppy upper eyelid and papillary conjunctivitis of the upper palpebral conjunctiva, were examined.
TL;DR: The "body packer syndrome" should be considered in any international traveler who dies suddenly, has seizures, or presents with any signs consistent with cocaine toxicity, as it is found in victims found dead at home or in hotel rooms with little or no drug paraphernalia.
Abstract: Ten fatalities and one survivor of attempts to smuggle cocaine within the body were investigated Most cases have occurred since 1979 All but one of the victims were male Victims found dead at home or in hotel rooms had little or no drug paraphernalia at the scene, although abundant laxatives and enema apparatus were often evident Some died aboard aircraft, and witnesses described agitated behavior followed by grand-mal type seizures, respiratory collapse, and death Seven victims presented to hospital emergency rooms The symptoms include mydriasis, seizures, acute toxic psychosis, and coma in various combinations One individual, realizing his plight, sought emergency room help by claiming he attempted suicide by using cocaine All victims had recently returned to the United States on flights from South America Balloons, condoms, or plastic bags filled with 3 to 6 g of cocaine each were swallowed and found in the gastrointestinal tract of eight victims One of these had ingested more than 147 packets totaling 460 g Two victims inserted packets of cocaine into their rectums, and one woman was found with nearly 170 g of cocaine in her vagina The packets, being semipermeable membranes, do not have to break open to cause death from acute cocaine toxicity Characteristic autopsy and radiologic findings, circumstances of death, and toxicologic data are presented The "body packer syndrome" should be considered in any international traveler who dies suddenly, has seizures, or presents with any signs consistent with cocaine toxicity
TL;DR: The junctional effects may represent a cyclic AMP-promoted proliferation of cell-to-cell channels and implications for hormone-regulated tissues are discussed.
Abstract: Mammalian cells in culture were exposed to cyclic AMP, dibutyrul cyclic AMP, the phosphodiesterase inhibitor caffeine, or a combination of the last two, while junctional molecular transfer was probed with the series of microinjected, fluorescentlabelled linear molecules Glu, Glu-Glu, Glu-Glu-Glu, and Leu-Leu-Leu-Glu-Glu. The junctional permeability for these molecules increased with each of the agents, most markedly with the dibutyryl cyclic AMP-caffeine combination, as the intracellular cyclic nucleotide concentration rose. The junctional permeability effect developed over several hours. When probed with molecules close to the limit of cell-to-cell channel permeation (the most sensitive setting), the effect was detectable both, as an increase in the (relative) junctional transit rate and as an increase in the number of transferring cell interfaces in the test populations. The number of transferring cell interfaces reached a maximum by 4 hr, when the junctional transit rate, hence the junctional permeability, was still rising. Nonjunctional membrane permeability for the probe molecules, as determined by intracellular fluorescence loss, was not significantly changed (nor was there significant nonjunctional cell-to-cell transfer of molecules before or after the treatments). The rise in junctional permeability was associated with an increase in the number of gap junctional membrane particles, as determined by freeze-fracture electron microscopy: the average size of the particle clusters increased, and the frequency of the clusters increased, particularly that of the smaller (and presumably newer) clusters. This effect was blocked by treatments with the protein synthesis inhibitors cycloheximide or puromycin. These agents caused particle diminution (diminution of cluster frequency but not of average cluster size), with or without cyclic nucleotide. The junctional effects may represent a cyclic AMP-promoted proliferation of cell-to-cell channels. Some physiological implications, in particular, implications for hormone-regulated tissues, are discussed.
TL;DR: The effectiveness of low-dose verapamil in controlling ventricular rate was evaluated in 20 patients with atrial fibrillation or flutter with a rapid ventricular response and 30 patients with paroxysmal supraventricular tachycardia (Group 2) as mentioned in this paper.
Abstract: The effectiveness of verapamil in controlling ventricular rate was evaluated in 20 patients with atrial fibrillation or flutter with a rapid ventricular response (Group 1) and 30 patients with paroxysmal supraventricular tachycardia (Group 2). In Group 1 low-dose verapamil (0.075 mg/kg body weight) decreased the mean ventricular rate from 146 to 114 beats/min (p < 0.01) compared to a decrease of 145 to 132 beats/min (p < 0.01) after placebo. In Group 2, 14 of 29 patients converted to sinus rhythm after low-dose verapamil, nine of 15 after high-dose verapamil (0.15 mg/kg body weight), and one of 24 after placebo (p < 0.01). We conclude that verapamil results in a clinically significant slowing of the ventricular response in atrial fibrillation or atrial flutter and is superior to placebo for conversion of paroxysmal supraventricular tachycardia to sinus rhythm.
TL;DR: In this article, an analytical method is proposed for calculating the nonlinear β-induced translation of isolated baroclinic eddies with a uniform anomalous density and a lens-like cross section which translates steadily in a resting Ocean.
Abstract: In this paper an analytical method is proposed for calculating the nonlinear β-induced translation of isolated baroclinic eddies. The study focuses on frictionless anticyclonic eddies with a uniform anomalous density and a lens-like cross section which translates steadily in a resting Ocean. The depth of these eddies vanishes along the outer edge so that as they translate westward their entire mass anomaly is caused along with them. The proposed method for calculating the translation speed incorporates the nonlinear equations of motion in an integrated form and a simple perturbation scheme. It relates the translation of the eddy to its intensity, size and volume, but requires only an approximate knowledge of the corresponding numerical values. The power and usefulness of the proposed method is demonstrated by its application to a class of simply-structured eddies whose swirl velocity increases monotonically with the distance from the center. It is found that the translation of these eddies is con...
TL;DR: Desensitization of acetylcholine (ACh) receptors was studied at the frog neuromuscular junction under voltage clamp under Voltage clamp in 1.1.
Abstract: 1. Desensitization of acetylcholine (ACh) receptors was studied at the frog neuromuscular junction under voltage clamp.
2. ACh was applied directly to junctional receptors by stimulating the motor nerve with trains of impulses. End-plate currents (e.p.c.s) were used to estimate the total number of channel openings by the junctional ACh receptors, and miniature end-plate currents (m.e.p.c.s) were used to measure changes in post-synaptic sensitivity. Under the conditions of these experiments the changes in m.e.p.c. amplitudes were shown to be post-synaptic in origin and thus provided a measure of desensitization.
3. When the acetylcholinesterase was inhibited with diisopropylfluorophosphate, neostigmine, or collagenase treatment to prolong the duration of the nerve-released ACh in the synaptic cleft, desensitization developed during repetitive stimulation of 1000 impulses at 5-33 impulses/sec and then recovered after the conditioning trains, with a time constant of about 25 sec.
4. When the acetylcholinesterase was active so that the duration of ACh in the synaptic cleft resulting from each nerve impulse was brief (< 300 μsec), desensitization developed in response to 300-500 pairs of nerve stimuli if the interval between the impulses of each pair was 25 msec or less. When the interval was 30 msec or greater, however, measurable desensitization did not occur, even if the total number of channel openings was many times greater than in the experiments with shorter intervals or inhibited esterase where desensitization readily occurred.
5. The desensitization observed to pairs of impulses was enhanced by chlorpromazine and decreased when the post-synaptic membrane was depolarized, properties similar to those described previously for desensitization to bath and ionophoretic application of ACh.
6. These results indicate that desensitization to nerve-released transmitter is not a simple consequence of receptor activation, is not due to blockade of the open receptor channels by ACh, and does not result from ACh binding directly to desensitized receptors with a resulting shift in the receptor population towards the desensitized state.
7. We suggest that the desensitization observed to nerve-released transmitter is a two-step process with both steps initiated by ACh. In the first step ACh converts some receptors into a desensitizable state which has an apparent lifetime of less than 30 msec; in the second step ACh desensitizes the desensitizable state.
TL;DR: In this article, a study was conducted to test the reasoning that two types of dispositional self-consciousness would be associated with two different influences on compliance behavior, and the data from the study provided support for both of these predictions.
TL;DR: The cell-to-cell channels in the junctions of an insect salivary gland and of insect and mammalian cells in culture were probed with fluorescent molecules-neutral linear oligosaccharides, neutral branched glycopeptides, and charged linear peptides.
Abstract: The cell-to-cell channels in the junctions of an insect salivary gland and of insect and mammalian cells in culture were probed with fluorescent molecules-neutral linear oligosaccharides, neutral branched glycopeptides, and charged linear peptides. From the molecular dimensions of the largest permeants and smallest impermeants the permeation-limiting channel diameter was obtained: 16 to 20 angstroms for the mammalian cells and 20 to 30 angstroms for the insect cells.
TL;DR: For instance, the authors found that volunteers over age sixty-five were compared to retired elderly who did not engage in any type of work activity, and volunteers were found to have significantly higher degree of life satisfaction, stronger will to live, and fewer symptoms of depression, anxiety, and somatization.
Abstract: Volunteer workers over age sixty-five were compared to retired elderly who did not engage in any type of work activity. Volunteers were found to have significantly higher degree of life satisfaction, stronger will to live, and fewer symptoms of depression, anxiety, and somatization. Since no differences were found on most demographic or background variables, participation in volunteer work appears to be the salient factor in explaining psychosocial differences between volunteers and non-volunteers.
TL;DR: Transmission electron microscopy and serial reconstruction of lum sections were used to determine whether aligned extracellular channels precede the outgrowth of optic fibers in the embryonic chick retina, suggesting that growth cones may be adherent to these structures.
TL;DR: Among Bergeron's many interests were climatology, the characteristics of the intertropical convergence zone and mineral dust in the atmosphere, the last because of the importance of soil particles in the process of ice nucleation as mentioned in this paper.
Abstract: Among Bergeron’s many interests were climatology, the characteristics of the intertropical convergence zone and mineral dust in the atmosphere, the last because of the importance of soil particles in the process of ice nucleation. Perhaps it was because of these interests that Bergeron was drawn to the study of the meteorology of North Africa where the climate in many regions is dominated by the behavior of the intertropical convergence zone and where dust is ubiquitous and abundant indeed. These interests and his humanitarian instincts converged to produce at least two papers (Bergeron, 1960, 1968) which dealt with the possibilities of employing weather modification techniques to increase rainfall in the arid and desert regions of North Africa.
TL;DR: Comparison with earlier population data suggests that the overall responses to the MRFIT eating pattern were limited by the apparent fact that participants had already made self-initiated changes toward the fatcontrolled dietary pattern before they entered the study.
TL;DR: It is concluded that platelet transfusions in patients with TTP may aggravate the disease process and platelet aggregates within the small blood vessels of the brain, whereas lesions elsewhere in the body consisted of platelets as well as fibrin.
Abstract: A patient with thrombotic thrombocytopenic purpura (TTP) showed for the first time catastrophic signs and symptoms of CNS involvement immediately after infusion of platelets. Postmortem examination revealed extensive deposits of platelet aggregates within the small blood vessels of the brain, whereas lesions elsewhere in the body consisted of platelets as well as fibrin and were associated with endothelial proliferation and microaneurysm formation. These findings are consistent with the view that the initial event in TTP may be platelet aggregation. The plasma of this patient contained platelet-aggregating activity. We conclude that platelet transfusions in patients with TTP may aggravate the disease process. (JAMA1981;246:1931-1933)
TL;DR: Results suggest that in the re-epithelization of superficial wounds laminin and type IV collagen are not present in the initial epidermal-dermal interaction of the migrating epithelium but that BP antigen may be important in this early interaction.
TL;DR: In this paper, the authors define facies belts: a rhythmic sequence of ooze and graded beds on the basin floors, subdivided into a basin-margin belt of coarse, thick turbidites and basin interior with fine turbidite; slope facies change with increase in height and declivity from accretionary to bypass to erosional regimes.