University of Miami

About: University of Miami is a education organization based out in Coral Gables, Florida, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 47313 authors who have published 97760 publications receiving 4043520 citations. The organization is also known as: UM & U of M.

Comprehensive molecular profiling of lung adenocarcinoma: The cancer genome atlas research network

Abstract: Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen (mean 8.9 mutations per megabase). Eighteen genes were statistically significantly mutated, including RIT1 activating mutations and newly described loss-of-function MGA mutations which are mutually exclusive with focal MYC amplification. EGFR mutations were more frequent in female patients, whereas mutations in RBM10 were more common in males. Aberrations in NF1, MET, ERBB2 and RIT1 occurred in 13% of cases and were enriched in samples otherwise lacking an activated oncogene, suggesting a driver role for these events in certain tumours. DNA and mRNA sequence from the same tumour highlighted splicing alterations driven by somatic genomic changes, including exon 14 skipping in MET mRNA in 4% of cases. MAPK and PI(3)K pathway activity, when measured at the protein level, was explained by known mutations in only a fraction of cases, suggesting additional, unexplained mechanisms of pathway activation. These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis.

The different roles of satisfaction, trust, and commitment in customer relationships

Abstract: Several theories of relationship marketing propose that customers vary in their relationships with a firm on a continuum from transactional to highly relational bonds. Few empirical studies have se...

On the Self-Regulation of Behavior

Abstract: 1. Introduction and plan 2. Principles of feedback control 3. Discrepancy reducing feedback processes in behavior 4. Discrepancy enlarging loops, and three further issues 5. Goals and behavior 6. Goals, hierarchicality, and behavior: further issues 7. Public and private aspects of the self 8. Control processes and affect 9. Affect: issues and comparisons 10. Expectancies and disengagement 11. Disengagement: issues and comparisons 12. Applications to problems in living 13. Hierarchicality and problems in living 14. Chaos and dynamic systems 15. Catastrophe theory 16. Further applications to problems in living 17. Is behavior controlled or does it emerge? 18. Goal engagement, life and death.

Effects of Price, Brand, and Store Information on Buyers’ Product Evaluations:

Abstract: The authors report a study of the effects of price, brand, and store information on buyers’ perceptions of product quality and value, as well as their willingness to buy Hypotheses are derived fro