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Institution

University of Milano-Bicocca

EducationMilan, Italy
About: University of Milano-Bicocca is a education organization based out in Milan, Italy. It is known for research contribution in the topics: Population & Blood pressure. The organization has 8972 authors who have published 22322 publications receiving 620484 citations. The organization is also known as: Università degli Studi di Milano-Bicocca & Universita degli Studi di Milano-Bicocca.


Papers
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Journal ArticleDOI
M. Aguilar, D. Aisa1, Behcet Alpat, A. Alvino  +291 moreInstitutions (33)
TL;DR: In this paper, a precise measurement of the proton flux in primary cosmic rays with rigidity (momentum/charge) from 1.GV to 1.8TV is presented based on 300 million events.
Abstract: A precise measurement of the proton flux in primary cosmic rays with rigidity (momentum/charge) from 1 GV to 1.8 TV is presented based on 300 million events. Knowledge of the rigidity dependence of the proton flux is important in understanding the origin, acceleration, and propagation of cosmic rays. We present the detailed variation with rigidity of the flux spectral index for the first time. The spectral index progressively hardens at high rigidities.

783 citations

Journal ArticleDOI
TL;DR: A new diagnostic indicator of FDG PET scan abnormality, based on age-adjusted t statistics and an automated voxel-based procedure, is presented and validated in a large data set comprising 110 normal controls and 395 patients with probable Alzheimer's disease (AD) that were studied in eight participating centers as discussed by the authors.

764 citations

Journal ArticleDOI
25 May 2012-Cell
TL;DR: A conformational change from the initially formed oligomers to stable, more compact proteinase-K-resistant oligomers is identified as the key step that leads ultimately to fibril formation, indicating a significant period of time for the cellular protective machinery to operate and potentially for therapeutic intervention, prior to the onset of cellular damage.

746 citations

Journal ArticleDOI
TL;DR: This paper will provide a concise overview of the mechanisms causing endothelial dysfunction in the different cardiovascular risk factors and disease conditions, and of the impact of the intervention measures and treatments.
Abstract: Dysfunction of the vascular endothelium is a hallmark of most conditions that are associated with atherosclerosis and is therefore held to be an early feature in atherogenesis. However, the mechanisms by which endothelial dysfunction occurs in smoking, dyslipidaemia, hyperhomocysteinaemia, diabetes mellitus, arterial hypertension, cerebrovascular diseases, coronary artery disease and heart failure are complex and heterogeneous. Recent data indicate that endothelial dysfunction is often associated with erectile dysfunction, which can precede and predict cardiovascular disease in men. This paper will provide a concise overview of the mechanisms causing endothelial dysfunction in the different cardiovascular risk factors and disease conditions, and of the impact of the intervention measures and treatments.

735 citations

Journal ArticleDOI
TL;DR: The complex genetic architecture of the risk regions of and refine the risk signals for celiac disease are defined, providing the next step toward uncovering the causal mechanisms of the disease.
Abstract: Using variants from the 1000 Genomes Project pilot European CEU dataset and data from additional resequencing studies, we densely genotyped 183 non-HLA risk loci previously associated with immune-mediated diseases in 12,041 individuals with celiac disease (cases) and 12,228 controls. We identified 13 new celiac disease risk loci reaching genome-wide significance, bringing the number of known loci (including the HLA locus) to 40. We found multiple independent association signals at over one-third of these loci, a finding that is attributable to a combination of common, low-frequency and rare genetic variants. Compared to previously available data such as those from HapMap3, our dense genotyping in a large sample collection provided a higher resolution of the pattern of linkage disequilibrium and suggested localization of many signals to finer scale regions. In particular, 29 of the 54 fine-mapped signals seemed to be localized to single genes and, in some instances, to gene regulatory elements. Altogether, we define the complex genetic architecture of the risk regions of and refine the risk signals for celiac disease, providing the next step toward uncovering the causal mechanisms of the disease.

715 citations


Authors

Showing all 9226 results

NameH-indexPapersCitations
Carlo Rovelli1461502103550
Giuseppe Mancia1451369139692
Marco Bersanelli142526105135
Teruki Kamon1422034115633
Marco Colonna13951271166
M. I. Martínez134125179885
A. Mennella13246393236
Roberto Salerno132119783409
Federico Ferri132137689337
Marco Paganoni132143888482
Arabella Martelli131131884029
Sandra Malvezzi129132684401
Andrea Massironi129111578457
Marco Pieri129128582914
Cristina Riccardi129162791452
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023173
2022349
20212,468
20202,253
20191,905
20181,706