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Institution

University of Milano-Bicocca

EducationMilan, Italy
About: University of Milano-Bicocca is a education organization based out in Milan, Italy. It is known for research contribution in the topics: Population & Blood pressure. The organization has 8972 authors who have published 22322 publications receiving 620484 citations. The organization is also known as: Università degli Studi di Milano-Bicocca & Universita degli Studi di Milano-Bicocca.


Papers
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Journal ArticleDOI
TL;DR: The available evidence on the prognostic importance of BP mean levels and of BP variability (BPV) estimates is reviewed to critically evaluate whether antihypertensive treatment strategies should be targeted at reducing not only average BP levels but also the degree of BPV in order to optimize CV protection in diabetic patients.
Abstract: Elevated blood pressure (BP) is a major risk factor for cardiovascular (CV) events and mortality (1) and a leading contributor to the global disease burden (2). Overwhelming evidence is now available showing that BP measured in the office shows a linear relationship with a number of CV and renal outcomes as well as with overall mortality and that lowering of office BP (OBP) with treatment is effective in reducing morbidity and mortality (3,4). However, application over the last 40 years of techniques for out-of-office BP monitoring including home BP monitoring (HBPM) and 24-h ambulatory BP monitoring (ABPM) has led to further important findings. In particular, 1 ) average BP measured in everyday life conditions may be an even better predictor of CV outcomes than isolated OBP readings and 2 ) the extent of fluctuations of BP over time may provide additional, independent prognostic information compared with both isolated office readings and average ambulatory BP (ABP) levels, respectively. These findings are of upmost relevance in the case of diabetic patients who are characterized by a significantly higher risk of CV events compared with nondiabetic individuals, with diabetes itself currently considered a CV disease equivalent (5,6). The aim of the present article is to review the available evidence on the prognostic importance of BP mean levels and of BP variability (BPV) estimates and to critically evaluate whether antihypertensive treatment strategies should be targeted at reducing not only average BP levels but also the degree of BPV in order to optimize CV protection in diabetic patients. ### Prognostic value of OBP values Consistent evidence from observational studies has indicated that the risk of CV morbidity and mortality has a strong and continuous relationship with OBP levels (3), without any evidence of a threshold down to at least 115/75 mmHg (4). Furthermore, large meta-analyses of major interventional trials …

138 citations

Journal ArticleDOI
TL;DR: In this article, defects acting as electron traps were investigated in the presence of oxygen vacancies acting as traps in rare-earth ionites, and the glow curves for both LSO and LYSO were compared by wavelength-resolved thermally stimulated luminescence (TSL) measurements from 20 to 400.
Abstract: We present an investigation of defects acting as electron traps in ${\text{Lu}}_{2}{\text{SiO}}_{5}$ (LSO) and ${\text{Lu}}_{x}{\text{Y}}_{2\ensuremath{-}x}{\text{SiO}}_{5}$ (LYSO) performed by wavelength-resolved thermally stimulated luminescence (TSL) measurements from 20 to $400\text{ }\ifmmode^\circ\else\textdegree\fi{}\text{C}$ after room-temperature (RT) x-ray irradiation Single crystals doped with several rare-earth ions such as Ce, Tb, Tm, and Sm were considered A comparison between TSL and RT radio-luminescence (RL) emission spectra is also presented The glow curves for both LSO and LYSO are similar, showing a series of TSL peaks at 78, 135, 181, and $236\text{ }\ifmmode^\circ\else\textdegree\fi{}\text{C}$ In addition, a further peak at about $300\text{ }\ifmmode^\circ\else\textdegree\fi{}\text{C}$ is observed only in LYSO Our results confirm the role of oxygen vacancies as electron traps in the material; the presence of several glow peaks with a unique trap depth $(099\text{ }\text{eV}\ifmmode\pm\else\textpm\fi{}007\text{ }\text{eV})$ for the 78, 135, 181, and $236\text{ }\ifmmode^\circ\else\textdegree\fi{}\text{C}$ peaks is explained by suggesting that electrons stored in oxygen vacancies recombine through a thermally assisted tunneling mechanism with holes localized at ${\text{Ce}}^{3+}$ or ${\text{Tb}}^{3+}$ centers residing on Lu sites at different crystallographic distances from the traps This model is supported by the very good correlation among O-Lu distances in the monoclinic $C2/c$ structure of LSO and LYSO and the frequency factors of the traps containing the transmission coefficients of the potential barriers between traps and centers, evaluated in the framework of the thermally assisted tunneling process Tm and Sm ions do not act as TSL recombination centers possibly due to their tendency to trap electrons during irradiation with ionizing radiation

138 citations

Journal ArticleDOI
TL;DR: A Bayesian hierarchical model is proposed to fulfil the aims of estimating the characteristics that bring a team to lose or win a game, or to predict the score of a particular match, and a more complex mixture model is specified that results in a better fit to the observed data.
Abstract: The problem of modelling football data has become increasingly popular in the last few years and many different models have been proposed with the aim of estimating the characteristics that bring a team to lose or win a game, or to predict the score of a particular match. We propose a Bayesian hierarchical model to fulfil both these aims and test its predictive strength based on data about the Italian Serie A 1991-1992 championship. To overcome the issue of overshrinkage produced by the Bayesian hierarchical model, we specify a more complex mixture model that results in a better fit to the observed data. We test its performance using an example of the Italian Serie A 2007-2008 championship.

138 citations

Journal ArticleDOI
Roel Aaij, C. Abellán Beteta1, Thomas Ackernley2, Bernardo Adeva3  +900 moreInstitutions (59)
TL;DR: In this article, an angular analysis of the B^{0}→K^{*0}(→K+}π^{-})μ^{+}μ^{-} decay is presented using a dataset corresponding to an integrated luminosity of 4.7 fb^{-1} of pp collision data collected with the LHCb experiment.
Abstract: An angular analysis of the B^{0}→K^{*0}(→K^{+}π^{-})μ^{+}μ^{-} decay is presented using a dataset corresponding to an integrated luminosity of 4.7 fb^{-1} of pp collision data collected with the LHCb experiment. The full set of CP-averaged observables are determined in bins of the invariant mass squared of the dimuon system. Contamination from decays with the K^{+}π^{-} system in an S-wave configuration is taken into account. The tension seen between the previous LHCb results and the standard model predictions persists with the new data. The precise value of the significance of this tension depends on the choice of theory nuisance parameters.

138 citations

Journal ArticleDOI
TL;DR: In this paper, the potentialities of cellulose nanocrystals (CNCs) as coatings for polyethylene terephthalate (PET) films were compared with two different processes: sulfuric acid hydrolysis and a less common treatment with ammonium persulfate (APS), able to provide also a cellulose oxidation.
Abstract: Cellulose nanocrystals (CNCs), extracted from trees, plants, or similar cellulose-containing materials, can be used in combination with other materials to improve their performance or introduce new applications. The main purpose of this study was to compare and understand the potentialities, as coatings for Poly(ethylene terephthalate) films, of CNCs obtained starting from the same cotton linters by two different processes: sulfuric acid hydrolysis and a less common treatment with ammonium persulfate (APS), able to provide also a cellulose oxidation. The results showed that CNCs produced through the APS treatment showed higher charge densities, due to the carboxylic groups formed during the process, higher crystallinity, higher clarity of the solution and, as a consequence, higher transparency of the coating. These characteristics provide a higher oxygen barrier with respect to the CNCs produced by the H2SO4 treatment, together with the availability of active sites for potential surface modification or chemical grafting. Both CNC coatings showed oxygen permeability coefficients that were lower than synthetic resins commonly used in flexible packaging. Furthermore, they did not significantly affect the optical properties of the substrate, while revealing good friction coefficients. Due though to the moisture sensitivity of the coating and its non-sealable nature, similar to EVOH or PVOH oxygen barrier synthetic resins, CNCs developed using APS will need to be laminated with another plastic layer such as a polyolefin. They could then be used to enhance the final properties of packaging solutions as an alternative to conventional food-packaging materials for perishable food products, while reducing their environmental impact with a thin layer of a bio-based polymer.

137 citations


Authors

Showing all 9226 results

NameH-indexPapersCitations
Carlo Rovelli1461502103550
Giuseppe Mancia1451369139692
Marco Bersanelli142526105135
Teruki Kamon1422034115633
Marco Colonna13951271166
M. I. Martínez134125179885
A. Mennella13246393236
Roberto Salerno132119783409
Federico Ferri132137689337
Marco Paganoni132143888482
Arabella Martelli131131884029
Sandra Malvezzi129132684401
Andrea Massironi129111578457
Marco Pieri129128582914
Cristina Riccardi129162791452
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023173
2022349
20212,468
20202,253
20191,905
20181,706