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Institution

University of Milano-Bicocca

EducationMilan, Italy
About: University of Milano-Bicocca is a education organization based out in Milan, Italy. It is known for research contribution in the topics: Population & Blood pressure. The organization has 8972 authors who have published 22322 publications receiving 620484 citations. The organization is also known as: Università degli Studi di Milano-Bicocca & Universita degli Studi di Milano-Bicocca.


Papers
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Journal ArticleDOI
TL;DR: In this article, the effect of dissipation on the orbital evolution of supermassive black holes (SMBHs) was analyzed using high-resolution self-consistent gas-dynamical simulations of binary equal-and unequal-mass mergers of disk galaxies.
Abstract: We analyze the effect of dissipation on the orbital evolution of supermassive black holes (SMBHs) using high-resolution self-consistent gasdynamical simulations of binary equal- and unequal-mass mergers of disk galaxies. The galaxy models are consistent with the LCDM paradigm of structure formation and the simulations include the effects of radiative cooling and star formation. We find that equal-mass mergers always lead to the formation of a close SMBH pair at the center of the remnant with separations limited solely by the adopted force resolution of ~ 100 pc. Instead, the final SMBH separation in unequal-mass mergers depends sensitively on how the central structure of the merging galaxies is modified by dissipation. In the absence of dissipation, the satellite galaxy can be entirely disrupted before the merger is completed leaving its SMBH wandering at a distance too far from the center of the remnant for the formation of a close pair. In contrast, we show that gas cooling facilitates the pairing process by increasing the resilience of the companion galaxy to tidal disruption. Moreover, we demonstrate that merging disk galaxies constructed to obey the M(BH)-sigma relation, move relative to it depending on whether they undergo a dissipational or collisionless merger, regardless of the mass ratio of the merging systems. Collisionless simulations reveal that remnants tend to move away from the mean relation highlighting the role of gas-poor mergers as a possible source of scatter. In dissipational mergers, the interplay between strong gas inflows associated with the formation of massive nuclear disks and the consumption of gas by star formation provides the necessary fuel to the SMBHs and allows the merger remnants to satisfy the relation.

135 citations

Journal ArticleDOI
TL;DR: Results from the SAMPLE trial show the superiority of mean 24-h, daytime and night-time blood pressures over clinic readings in predicting the regression of left ventricular mass index in treated hypertensive patients and a direct, positive relationship has been established between 24-H blood pressure variability and the severity and rate of progression of end-organ damage.
Abstract: The ultimate goal when treating high blood pressure is to reduce the incidence of end-organ damage and prevent cardiovascular disease, and thus reduce the incidence of premature death. Cuff blood pressure measurements have some prognostic value and have traditionally been used to predict the risk of end-organ damage. Such measurements, however, do not reflect accurately the 24-h mean blood pressure and hourly variations. For any value of cuff blood pressure, a lower 24-h mean blood pressure was associated with a lower prevalence and severity of end-organ damage. In the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study, data from 24-h ambulatory blood pressure monitoring (ABPM) were more strongly associated with prognosis than other blood pressure data. Longitudinal evidence of the clinical relevance of 24-h ABPM data in predicting cardiovascular risk is less extensive. However, results from the Study on Ambulatory Monitoring of Pressure and Lisinopril Evaluation (SAMPLE) trial show the superiority of mean 24-h, daytime and night-time blood pressures over clinic readings in predicting the regression of left ventricular mass index in treated hypertensive patients. Furthermore, a direct, positive relationship has been established between 24-h blood pressure variability and the severity and rate of progression of end-organ damage. In addition, ABPM data demonstrate that hypertensive patients who do not exhibit a nocturnal reduction in blood pressure have a higher incidence of end-organ damage. Future directions for research and treatment of hypertension will need to consider the circadian cycle of blood pressure, the effect of treatment on blood pressure variability, and the magnitude of blood pressure changes in daily life.

134 citations

Journal ArticleDOI
TL;DR: This article suggests that different mechanisms can lead to inactivation of different lipases, in particular substrate inhibition and protein unfolding, and attempts to improve the performances of methanol sensitive lipases by mutagenesis as well as process engineering approaches are suggested.
Abstract: The biotechnological production of biodiesel is based on transesterification/esterification reactions between a source of fatty acids and a short-chain alcohol, usually methanol, catalysed by enzymes belonging to the class known as lipases. Several lipases used in industrial processes, although stable in the presence of other organic solvents, are inactivated by methanol at or below the concentration optimal for biodiesel production, making it necessary to use stepwise methanol feeding or pre-treatment of the enzyme. In this review article we focus on what is currently know about methanol inactivation of lipases, a phenomenon which is not common to all lipase enzymes, with the goal of improving the biocatalytic process. We suggest that different mechanisms can lead to inactivation of different lipases, in particular substrate inhibition and protein unfolding. Attempts to improve the performances of methanol sensitive lipases by mutagenesis as well as process engineering approaches are also summarized.

134 citations

Journal ArticleDOI
01 Apr 2005-Facies
TL;DR: The SML coral banks represent so far a unique example of living Lophelia-bearing coral mounds in the Mediterranean basin this article and are located between ca. 300 and 1,100m on a gently dipping shelf off Apulia at Santa Maria di Leuca (SML), and characterized by a complex seabed topography.
Abstract: Prosperous deep coral mounds including living colonies of Lophelia pertusa together with Madrepora oculata and Desmophyllum dianthus (= D. cristagalli) have been discovered in 2000, by fishery operations on the eastern side of the Ionian Sea. The living coral mounds are located between ca. 300 and 1,100 m on a gently dipping shelf off Apulia at Santa Maria di Leuca (SML), and characterized by a complex seabed topography. Side scan sonar, shallow high-resolution seismics and sampling indicate that these Lophelia-bearing coral mounds colonize quasi-indurate (firmground) Pleistocene sediment. At places live corals were found on Pleistocene coral-hardgrounds. The fauna associated with these Ionian modern coral mounds is less diversified than modern Eastern Atlantic counterparts. The core of living coral mounds colonies is at present located in 500–700 m and is tentatively suggested that their survival is mostly controlled by oceanographic factors. The SML coral banks represent so far a unique example of living Lophelia-bearing coral mounds in the Mediterranean basin.

134 citations


Authors

Showing all 9226 results

NameH-indexPapersCitations
Carlo Rovelli1461502103550
Giuseppe Mancia1451369139692
Marco Bersanelli142526105135
Teruki Kamon1422034115633
Marco Colonna13951271166
M. I. Martínez134125179885
A. Mennella13246393236
Roberto Salerno132119783409
Federico Ferri132137689337
Marco Paganoni132143888482
Arabella Martelli131131884029
Sandra Malvezzi129132684401
Andrea Massironi129111578457
Marco Pieri129128582914
Cristina Riccardi129162791452
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023173
2022349
20212,468
20202,253
20191,905
20181,706