University of Milano-Bicocca

About: University of Milano-Bicocca is a education organization based out in Milan, Italy. It is known for research contribution in the topics: Population & Blood pressure. The organization has 8972 authors who have published 22322 publications receiving 620484 citations. The organization is also known as: Università degli Studi di Milano-Bicocca & Universita degli Studi di Milano-Bicocca.

The Haplotyping problem: an overview of computational models and solutions

Abstract: The investigation of genetic differences among humans has given evidence that mutations in DNA sequences are responsible for some genetic diseases. The most common mutation is the one that involves only a single nucleotide of the DNA sequence, which is called a single nucleotide polymorphism (SNP). As a consequence, computing a complete map of all SNPs occurring in the human populations is one of the primary goals of recent studies in human genomics. The construction of such a map requires to determine the DNA sequences that from all chromosomes. In diploid organisms like humans, each chromosome consists of two sequences called haplotypes. Distinguishing the information contained in both haplotypes when analyzing chromosome sequences poses several new computational issues which collectively form a new emerging topic of Computational Biology known as Haplotyping.This paper is a comprehensive study of some new combinatorial approaches proposed in this research area and it mainly focuses on the formulations and algorithmic solutions of some basic biological problems. Three statistical approaches are briefly discussed at the end of the paper.

A Positive-Weight Next-to-Leading-Order Monte Carlo for Z Pair Hadroproduction

Abstract: We present a first application of a previously published method for the computation of QCD processes that is accurate at next-to-leading order, and that can be interfaced consistently to standard shower Monte Carlo programs. We have considered Z pair production in hadron-hadron collisions, a process whose complexity is sufficient to test the general applicability of the method. We have interfaced our result to the HERWIG and PYTHIA shower Monte Carlo programs. Previous work on next-to-leading order corrections in a shower Monte Carlo (the MC@NLO program) may involve the generation of events with negative weights, that are avoided with the present method. We have compared our results with those obtained with MC@NLO, and found remarkable consistency. Our method can also be used as a standalone, alternative implementation of QCD corrections, with the advantage of positivity, improved convergence, and next-to-leading logarithmic accuracy in the region of small transverse momentum of the radiated parton.

Model-Independent Evidence for J /ψp Contributions to Λb0 →j /ψpK- Decays

Abstract: The data sample of Lambda(0)(b) -> J/psi pK(-) decays acquired with the LHCb detector from 7 and 8 TeV pp collisions, corresponding to an integrated luminosity of 3 fb(-1), is inspected for the presence of J/psi p or J/psi K- contributions with minimal assumptions about K(-)p contributions. It is demonstrated at more than nine standard deviations that Lambda(0)(b) -> J/psi pK(-) decays cannot be described with K- p contributions alone, and that J/psi K- contributions play a dominant role in this incompatibility. These model-independent results support the previously obtained model-dependent evidence for P-c(+)-> J/psi p charmonium-pentaquark states in the same data sample.