University of Milano-Bicocca

About: University of Milano-Bicocca is a education organization based out in Milan, Italy. It is known for research contribution in the topics: Population & Blood pressure. The organization has 8972 authors who have published 22322 publications receiving 620484 citations. The organization is also known as: Università degli Studi di Milano-Bicocca & Universita degli Studi di Milano-Bicocca.

Investigating microbial (micro)colony heterogeneity by vibrational spectroscopy.

Abstract: Fourier transform infrared and Raman microspectroscopy are currently being developed as new methods for the rapid identification of clinically relevant microorganisms. These methods involve measuring spectra from microcolonies which have been cultured for as little as 6 h, followed by the nonsubjective identification of microorganisms through the use of multivariate statistical analyses. To examine the biological heterogeneity of microorganism growth which is reflected in the spectra, measurements were acquired from various positions within (micro)colonies cultured for 6, 12, and 24 h. The studies reveal that there is little spectral variance in 6-h microcolonies. In contrast, the 12- and 24-h cultures exhibited a significant amount of heterogeneity. Hierarchical cluster analysis of the spectra from the various positions and depths reveals the presence of different layers in the colonies. Further analysis indicates that spectra acquired from the surface of the colonies exhibit higher levels of glycogen than do the deeper layers of the colony. Additionally, the spectra from the deeper layers present with higher RNA levels than the surface layers. Therefore, the 6-h colonies with their limited heterogeneity are more suitable for inclusion in a spectral database to be used for classification purposes. These results also demonstrate that vibrational spectroscopic techniques can be useful tools for studying the nature of colony development and biofilm formation.

Ground states of nonlinear Schrödinger equations with potentials vanishing at infinity

Abstract: We deal with a class on nonlinear Schr\"odinger equations \eqref{eq:1} with potentials $V(x)\sim |x|^{-\a}$, $0 0$. Working in weighted Sobolev spaces, the existence of ground states $v_{\e}$ belonging to $W^{1,2}(\Rn)$ is proved under the assumption that $p$ satisfies \eqref{eq:p}. Furthermore, it is shown that $v_{\e}$ are {\em spikes} concentrating at a minimum of ${\cal A}=V^{\theta}K^{-2/(p-1)}$, where $\theta= (p+1)/(p-1)-1/2$.

Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia: Results of the Randomized Intercontinental Trial ALL IC-BFM 2002

Abstract: Purpose From 2002 to 2007, the International Berlin-Frankfurt-Munster Study Group conducted a prospective randomized clinical trial (ALL IC-BFM 2002) for the management of childhood acute lymphoblastic leukemia (ALL) in 15 countries on three continents. The aim of this trial was to explore the impact of differential delayed intensification (DI) on outcome in all risk groups. Patients and Methods For this trial, 5,060 eligible patients were divided into three risk groups according to age, WBC, early treatment response, and unfavorable genetic aberrations. DI was randomized as follows: standard risk (SR), two 4-week intensive elements (protocol III) versus one 7-week protocol II; intermediate risk (IR), protocol III × 3 versus protocol II × 1; high risk (HR), protocol III × 3 versus either protocol II × 2 (Associazione Italiana Ematologia Oncologia Pediatrica [AIEOP] option), or 3 HR blocks plus single protocol II (Berlin-Frankfurt-Munster [BFM] option). Results At 5 years, the probabilities of event-free s...

Monopole operators and Hilbert series of Coulomb branches of 3d \mathcal{N} = 4 gauge theories

Abstract: This paper addresses a long standing problem - to identify the chiral ring and moduli space (i.e. as an algebraic variety) on the Coulomb branch of an $ \mathcal{N} $ = 4 superconformal field theory in 2+1 dimensions. Previous techniques involved a computation of the metric on the moduli space and/or mirror symmetry. These methods are limited to sufficiently small moduli spaces, with enough symmetry, or to Higgs branches of sufficiently small gauge theories. We introduce a simple formula for the Hilbert series of the Coulomb branch, which applies to any good or ugly three-dimensional $ \mathcal{N} $ = 4 gauge theory. The formula counts monopole operators which are dressed by classical operators, the Casimir invariants of the residual gauge group that is left unbroken by the magnetic flux. We apply our formula to several classes of gauge theories. Along the way we make various tests of mirror symmetry, successfully comparing the Hilbert series of the Coulomb branch with the Hilbert series of the Higgs branch of the mirror theory.

Better compliance to antihypertensive medications reduces cardiovascular risk.

Abstract: ObjectiveThe effect of compliance with antihypertensive medications on the risk of cardiovascular outcomes in a population without a known history of cardiovascular disease has been addressed by a large population-based prospective, cohort study carried out by linking Italian administrative database