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Institution

University of Minnesota

EducationMinneapolis, Minnesota, United States
About: University of Minnesota is a education organization based out in Minneapolis, Minnesota, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 117432 authors who have published 257986 publications receiving 11944239 citations. The organization is also known as: University of Minnesota, Twin Cities & University of Minnesota-Twin Cities.


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Journal ArticleDOI
21 Mar 2007-JAMA
TL;DR: The reduction of atherosclerotic arterial disease (REACH) registry as discussed by the authors is an international, prospective cohort of 68,236 patients with either established coronary artery disease (CAD, PAD, CVD), or at least three risk factors for atherothrombosis (n = 12,422).
Abstract: ContextFew data document current cardiovascular (CV) event rates in stable patients with atherothrombosis in a community setting. Differential event rates for patients with documented coronary artery disease (CAD), cerebrovascular disease (CVD), or peripheral arterial disease (PAD) or those at risk of these diseases have not been previously evaluated in a single international cohort.ObjectiveTo establish contemporary, international, 1-year CV event rates in outpatients with established arterial disease or with multiple risk factors for atherothrombosis.Design, Setting, and ParticipantsThe Reduction of Atherothrombosis for Continued Health (REACH) Registry is an international, prospective cohort of 68 236 patients with either established atherosclerotic arterial disease (CAD, PAD, CVD; n = 55 814) or at least 3 risk factors for atherothrombosis (n = 12 422), who were enrolled from 5587 physician practices in 44 countries in 2003-2004.Main Outcome MeasuresRates of CV death, myocardial infarction (MI), and stroke.ResultsAs of July 2006, 1-year outcomes were available for 95.22% (n = 64 977) of participants. Cardiovascular death, MI, or stroke rates were 4.24% overall: 4.69% for those with established atherosclerotic arterial disease vs 2.15% for patients with multiple risk factors only. Among patients with established disease, CV death, MI, or stroke rates were 4.52% for patients with CAD, 6.47% for patients with CVD, and 5.35% for patients with PAD. The incidences of the end point of CV death, MI, or stroke or of hospitalization for atherothrombotic event(s) were 15.20% for CAD, 14.53% for CVD, and 21.14% for PAD patients with established disease. These event rates increased with the number of symptomatic arterial disease locations, ranging from 5.31% for patients with risk factors only to 12.58% for patients with 1, 21.14% for patients with 2, and 26.27% for patients with 3 symptomatic arterial disease locations (P<.001 for trend).ConclusionsIn this large, contemporary, international study, outpatients with established atherosclerotic arterial disease, or at risk of atherothrombosis, experienced relatively high annual CV event rates. Multiple disease locations increased the 1-year risk of CV events.

1,156 citations

Journal ArticleDOI
TL;DR: The authors argue that scholars of international relations should employ multiple conceptions of power and develop a conceptual framework that encourages rigorous attention to power in its different forms, and illustrate how attention to the multiple forms of power matters for the analysis of global governance and American empire.
Abstract: The concept of power is central to international relations. Yet disciplin- ary discussions tend to privilege only one, albeit important, form: an actor control- ling another to do what that other would not otherwise do. By showing conceptual favoritism, the discipline not only overlooks the different forms of power in inter- national politics, but also fails to develop sophisticated understandings of how global outcomes are produced and how actors are differentially enabled and constrained to determine their fates. We argue that scholars of international relations should employ multiple conceptions of power and develop a conceptual framework that encourages rigorous attention to power in its different forms. We first begin by producing a tax- onomy of power. Power is the production, in and through social relations, of effects that shape the capacities of actors to determine their circumstances and fate. This general concept entails two crucial, analytical dimensions: the kinds of social rela- tions through which power works (in relations of interaction or in social relations of constitution); and the specificity of social relations through which effects are pro- duced (specific/direct or diffuse/indirect). These distinctions generate our taxonomy and four concepts of power: compulsory, institutional, structural, and productive. We then illustrate how attention to the multiple forms of power matters for the analysis of global governance and American empire. We conclude by urging scholars to beware of the idea that the multiple concepts are competing, and instead to see connections between them in order to generate more robust understandings of how power works in international politics.

1,156 citations

Journal ArticleDOI
Nevin D. Young1, Frédéric Debellé2, Frédéric Debellé3, Giles E. D. Oldroyd4, René Geurts5, Steven B. Cannon6, Steven B. Cannon7, Michael K. Udvardi, Vagner A. Benedito8, Klaus F. X. Mayer, Jérôme Gouzy3, Jérôme Gouzy2, Heiko Schoof9, Yves Van de Peer10, Sebastian Proost10, Douglas R. Cook11, Blake C. Meyers12, Manuel Spannagl, Foo Cheung13, Stéphane De Mita5, Vivek Krishnakumar13, Heidrun Gundlach, Shiguo Zhou14, Joann Mudge15, Arvind K. Bharti15, Jeremy D. Murray4, Marina Naoumkina, Benjamin D. Rosen11, Kevin A. T. Silverstein1, Haibao Tang13, Stephane Rombauts10, Patrick X. Zhao, Peng Zhou1, Valérie Barbe, Philippe Bardou3, Philippe Bardou2, Michael Bechner14, Arnaud Bellec2, Anne Berger, Hélène Bergès2, Shelby L. Bidwell13, Ton Bisseling16, Ton Bisseling5, Nathalie Choisne, Arnaud Couloux, Roxanne Denny1, Shweta Deshpande17, Xinbin Dai, Jeff J. Doyle18, Anne Marie Dudez2, Anne Marie Dudez3, Andrew Farmer15, Stéphanie Fouteau, Carolien Franken5, Chrystel Gibelin3, Chrystel Gibelin2, John Gish11, Steven A. Goldstein14, Alvaro J. González12, Pamela J. Green12, Asis Hallab19, Marijke Hartog5, Axin Hua17, Sean Humphray20, Dong-Hoon Jeong12, Yi Jing17, Anika Jöcker19, Steve Kenton17, Dong-Jin Kim21, Dong-Jin Kim11, Kathrin Klee19, Hongshing Lai17, Chunting Lang5, Shaoping Lin17, Simone L. Macmil17, Ghislaine Magdelenat, Lucy Matthews20, Jamison McCorrison13, Erin L. Monaghan13, Jeong Hwan Mun22, Jeong Hwan Mun11, Fares Z. Najar17, Christine Nicholson20, Céline Noirot2, Majesta O'Bleness17, Charles Paule1, Julie Poulain, Florent Prion2, Florent Prion3, Baifang Qin17, Chunmei Qu17, Ernest F. Retzel15, Claire Riddle20, Erika Sallet3, Erika Sallet2, Sylvie Samain, Nicolas Samson2, Nicolas Samson3, Iryna Sanders17, Olivier Saurat3, Olivier Saurat2, Claude Scarpelli, Thomas Schiex2, Béatrice Segurens, Andrew J. Severin7, D. Janine Sherrier12, Ruihua Shi17, Sarah Sims20, Susan R. Singer23, Senjuti Sinharoy, Lieven Sterck10, Agnès Viollet, Bing Bing Wang1, Keqin Wang17, Mingyi Wang, Xiaohong Wang1, Jens Warfsmann19, Jean Weissenbach, Doug White17, James D. White17, Graham B. Wiley17, Patrick Wincker, Yanbo Xing17, Limei Yang17, Ziyun Yao17, Fu Ying17, Jixian Zhai12, Liping Zhou17, Antoine Zuber2, Antoine Zuber3, Jean Dénarié3, Jean Dénarié2, Richard A. Dixon, Gregory D. May15, David C. Schwartz14, Jane Rogers24, Francis Quetier, Christopher D. Town13, Bruce A. Roe17 
22 Dec 2011-Nature
TL;DR: The draft sequence of the M. truncatula genome sequence is described, a close relative of alfalfa (Medicago sativa), a widely cultivated crop with limited genomics tools and complex autotetraploid genetics, which provides significant opportunities to expand al falfa’s genomic toolbox.
Abstract: Legumes (Fabaceae or Leguminosae) are unique among cultivated plants for their ability to carry out endosymbiotic nitrogen fixation with rhizobial bacteria, a process that takes place in a specialized structure known as the nodule. Legumes belong to one of the two main groups of eurosids, the Fabidae, which includes most species capable of endosymbiotic nitrogen fixation. Legumes comprise several evolutionary lineages derived from a common ancestor 60 million years ago (Myr ago). Papilionoids are the largest clade, dating nearly to the origin of legumes and containing most cultivated species. Medicago truncatula is a long-established model for the study of legume biology. Here we describe the draft sequence of the M. truncatula euchromatin based on a recently completed BAC assembly supplemented with Illumina shotgun sequence, together capturing ∼94% of all M. truncatula genes. A whole-genome duplication (WGD) approximately 58 Myr ago had a major role in shaping the M. truncatula genome and thereby contributed to the evolution of endosymbiotic nitrogen fixation. Subsequent to the WGD, the M. truncatula genome experienced higher levels of rearrangement than two other sequenced legumes, Glycine max and Lotus japonicus. M. truncatula is a close relative of alfalfa (Medicago sativa), a widely cultivated crop with limited genomics tools and complex autotetraploid genetics. As such, the M. truncatula genome sequence provides significant opportunities to expand alfalfa's genomic toolbox.

1,153 citations

Journal ArticleDOI
TL;DR: This guideline update used an existing systematic evidence review of the CRC screening literature and microsimulation modeling analyses, including a new evaluation of the age to begin screening by race and sex and additional modeling that incorporates changes in US CRC incidence.
Abstract: In the United States, colorectal cancer (CRC) is the fourth most common cancer diagnosed among adults and the second leading cause of death from cancer. For this guideline update, the American Cancer Society (ACS) used an existing systematic evidence review of the CRC screening literature and microsimulation modeling analyses, including a new evaluation of the age to begin screening by race and sex and additional modeling that incorporates changes in US CRC incidence. Screening with any one of multiple options is associated with a significant reduction in CRC incidence through the detection and removal of adenomatous polyps and other precancerous lesions and with a reduction in mortality through incidence reduction and early detection of CRC. Results from modeling analyses identified efficient and model-recommendable strategies that started screening at age 45 years. The ACS Guideline Development Group applied the Grades of Recommendations, Assessment, Development, and Evaluation (GRADE) criteria in developing and rating the recommendations. The ACS recommends that adults aged 45 years and older with an average risk of CRC undergo regular screening with either a high-sensitivity stool-based test or a structural (visual) examination, depending on patient preference and test availability. As a part of the screening process, all positive results on noncolonoscopy screening tests should be followed up with timely colonoscopy. The recommendation to begin screening at age 45 years is a qualified recommendation. The recommendation for regular screening in adults aged 50 years and older is a strong recommendation. The ACS recommends (qualified recommendations) that: 1) average-risk adults in good health with a life expectancy of more than 10 years continue CRC screening through the age of 75 years; 2) clinicians individualize CRC screening decisions for individuals aged 76 through 85 years based on patient preferences, life expectancy, health status, and prior screening history; and 3) clinicians discourage individuals older than 85 years from continuing CRC screening. The options for CRC screening are: fecal immunochemical test annually; high-sensitivity, guaiac-based fecal occult blood test annually; multitarget stool DNA test every 3 years; colonoscopy every 10 years; computed tomography colonography every 5 years; and flexible sigmoidoscopy every 5 years. CA Cancer J Clin 2018;68:250-281. © 2018 American Cancer Society.

1,153 citations

Journal ArticleDOI
17 Sep 2008-Nature
TL;DR: The development of processes for selective hydrocarbon oxidation is a goal that has long been pursued, and extensive studies have revealed the key chemical principles that underlie their efficacy as catalysts for aerobic oxidations.
Abstract: The development of processes for selective hydrocarbon oxidation is a goal that has long been pursued. An additional challenge is to make such processes environmentally friendly, for example by using non-toxic reagents and energy-efficient catalytic methods. Excellent examples are naturally occurring iron- or copper-containing metalloenzymes, and extensive studies have revealed the key chemical principles that underlie their efficacy as catalysts for aerobic oxidations. Important inroads have been made in applying this knowledge to the development of synthetic catalysts that model enzyme function. Such biologically inspired hydrocarbon oxidation catalysts hold great promise for wide-ranging synthetic applications.

1,151 citations


Authors

Showing all 118112 results

NameH-indexPapersCitations
Walter C. Willett3342399413322
David J. Hunter2131836207050
David Miller2032573204840
Mark I. McCarthy2001028187898
Dennis W. Dickson1911243148488
David H. Weinberg183700171424
Eric Boerwinkle1831321170971
John C. Morris1831441168413
Aaron R. Folsom1811118134044
H. S. Chen1792401178529
Jie Zhang1784857221720
Jasvinder A. Singh1762382223370
Feng Zhang1721278181865
Gang Chen1673372149819
Hongfang Liu1662356156290
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023200
20221,176
202111,903
202011,807
201910,984
201810,367