Institution
University of Minnesota
Education•Minneapolis, Minnesota, United States•
About: University of Minnesota is a education organization based out in Minneapolis, Minnesota, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 117432 authors who have published 257986 publications receiving 11944239 citations. The organization is also known as: University of Minnesota, Twin Cities & University of Minnesota-Twin Cities.
Topics: Population, Transplantation, Poison control, Health care, Cancer
Papers published on a yearly basis
Papers
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TL;DR: High incidences of PTDM are associated with the type of initial maintenance immunosuppression, race, ethnicity, obesity and hepatitis C infection, and it is a strong, independent predictor of graft failure and mortality.
1,129 citations
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1,128 citations
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TL;DR: It is shown that, upon scaling, the balanced multicoefficient correlation method based on coupled cluster theory with single and double excitations (BMC-CCSD) can lead to very accurate predictions of vibrational frequencies.
Abstract: Optimized scale factors for calculating vibrational harmonic and fundamental frequencies and zero-point energies have been determined for 145 electronic model chemistries, including 119 based on approximate functionals depending on occupied orbitals, 19 based on single-level wave function theory, three based on the neglect-of-diatomic-differential-overlap, two based on doubly hybrid density functional theory, and two based on multicoefficient correlation methods. Forty of the scale factors are obtained from large databases, which are also used to derive two universal scale factor ratios that can be used to interconvert between scale factors optimized for various properties, enabling the derivation of three key scale factors at the effort of optimizing only one of them. A reduced scale factor optimization model is formulated in order to further reduce the cost of optimizing scale factors, and the reduced model is illustrated by using it to obtain 105 additional scale factors. Using root-mean-square errors from the values in the large databases, we find that scaling reduces errors in zero-point energies by a factor of 2.3 and errors in fundamental vibrational frequencies by a factor of 3.0, but it reduces errors in harmonic vibrational frequencies by only a factor of 1.3. It is shown that, upon scaling, the balanced multicoefficient correlation method based on coupled cluster theory with single and double excitations (BMC-CCSD) can lead to very accurate predictions of vibrational frequencies. With a polarized, minimally augmented basis set, the density functionals with zero-point energy scale factors closest to unity are MPWLYP1M (1.009), τHCTHhyb (0.989), BB95 (1.012), BLYP (1.013), BP86 (1.014), B3LYP (0.986), MPW3LYP (0.986), and VSXC (0.986).
1,128 citations
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TL;DR: The hypothesis that microglia are the source of a neurocytotoxic-free radical is supported, and light is shed on an additional mechanism of immune-mediated brain injury.
Abstract: Activated microglial have been proposed to play a pathogenetic role in immune-mediated neurodegenerative diseases. To test this hypothesis, purified murine neonatal microglial were cocultured with neuronal cells derived from fetal brain. Activation with IFN-gamma and LPS of these cocultures brought about a sharp decrease in uptake of gamma-amino butyric acid and a marked reduction in neuronal cell survival. These effects varied with the density of microglia, the concentrations of the activation signals (IFN-gamma and LPS), and the duration of coculture. Inasmuch as addition of NG-monomethyl-L-arginine blocked these effects, a L-arginine-dependent neurocytotoxic mechanism was implicated. Abundant nitrite, a metabolite of the free radical nitric oxide (NO) derived from L-arginine, was detected in activated microglial/neuronal cell cocultures and in purified microglial cell cultures but not in purified astrocyte or neuronal cell cultures, suggesting that microglial were the principal source of the NO. These findings support the hypothesis that microglia are the source of a neurocytotoxic-free radical, and shed light on an additional mechanism of immune-mediated brain injury.
1,127 citations
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01 Jun 1978TL;DR: In this article, the authors describe work which has been carried out under the subject grant during the period from April 1, 1961, to October 1, 2011, with technical supervision and guidance provided by Mr. Seymour Lieblein, Chief, Flow Physics Branch, NASA Lewis Research Center, Cleveland, Ohio.
Abstract: The pm-pose of this report is to describe work which has been carried out under the subject grant during the period from April 1, 1961, to October 1, 1961. Technical supervision and guidance of the work was provided by Mr. Seymour Lieblein, Chief, Flow Physics Branch, NASA Lewis Research Center, Cleveland, Ohio.
1,127 citations
Authors
Showing all 118112 results
Name | H-index | Papers | Citations |
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Walter C. Willett | 334 | 2399 | 413322 |
David J. Hunter | 213 | 1836 | 207050 |
David Miller | 203 | 2573 | 204840 |
Mark I. McCarthy | 200 | 1028 | 187898 |
Dennis W. Dickson | 191 | 1243 | 148488 |
David H. Weinberg | 183 | 700 | 171424 |
Eric Boerwinkle | 183 | 1321 | 170971 |
John C. Morris | 183 | 1441 | 168413 |
Aaron R. Folsom | 181 | 1118 | 134044 |
H. S. Chen | 179 | 2401 | 178529 |
Jie Zhang | 178 | 4857 | 221720 |
Jasvinder A. Singh | 176 | 2382 | 223370 |
Feng Zhang | 172 | 1278 | 181865 |
Gang Chen | 167 | 3372 | 149819 |
Hongfang Liu | 166 | 2356 | 156290 |