University of Minnesota

About: University of Minnesota is a education organization based out in Minneapolis, Minnesota, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 117432 authors who have published 257986 publications receiving 11944239 citations. The organization is also known as: University of Minnesota, Twin Cities & University of Minnesota-Twin Cities.

The Meaning Maintenance Model: On the Coherence of Social Motivations

Abstract: The meaning maintenance model (MMM) proposes that people have a need for meaning; that is, a need to perceive events through a prism of mental representations of expected relations that organizes their perceptions of the world. When people's sense of meaning is threatened, they reaffirm alternative representations as a way to regain meaning-a process termed fluid compensation. According to the model, people can reaffirm meaning in domains that are different from the domain in which the threat occurred. Evidence for fluid compensation can be observed following a variety of psychological threats, including most especially threats to the self, such as self-esteem threats, feelings of uncertainty, interpersonal rejection, and mortality salience. People respond to these diverse threats in highly similar ways, which suggests that a range of psychological motivations are expressions of a singular impulse to generate and maintain a sense of meaning.

The association of registered nurse staffing levels and patient outcomes: systematic review and meta-analysis.

Abstract: (OR, 0.49; 95% CI, 0.36‐0.67), respiratory failure (OR, 0.40; 95% CI, 0.27‐0.59), and cardiac arrest (OR, 0.72; 95% CI, 0.62‐0.84) in ICUs, with a lower risk of failure to rescue (OR, 0.84; 95% CI, 0.79‐0.90) in surgical patients. Length of stay was shorter by 24% in ICUs (OR, 0.76; 95% CI, 0.62‐0.94) and by 31% in surgical patients (OR, 0.69; 95% CI, 0.55‐0.86). Conclusions: Studies with different design show associations between increased RN staffing and lower odds of hospital related mortality and adverse patient events. Patient and hospital characteristics, including hospitals’ commitment to quality of medical care, likely contribute to the actual causal pathway.

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

Abstract: Recent genome-wide association studies (GWASs) have identified a locus on chromosome 1p13 strongly associated with both plasma low-density lipoprotein cholesterol (LDL-C) and myocardial infarction (MI) in humans. Here we show through a series of studies in human cohorts and human-derived hepatocytes that a common noncoding polymorphism at the 1p13 locus, rs12740374, creates a C/EBP (CCAAT/enhancer binding protein) transcription factor binding site and alters the hepatic expression of the SORT1 gene. With small interfering RNA (siRNA) knockdown and viral overexpression in mouse liver, we demonstrate that Sort1 alters plasma LDL-C and very low-density lipoprotein (VLDL) particle levels by modulating hepatic VLDL secretion. Thus, we provide functional evidence for a novel regulatory pathway for lipoprotein metabolism and suggest that modulation of this pathway may alter risk for MI in humans. We also demonstrate that common noncoding DNA variants identified by GWASs can directly contribute to clinical phenotypes.