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Institution

University of Minnesota

EducationMinneapolis, Minnesota, United States
About: University of Minnesota is a education organization based out in Minneapolis, Minnesota, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 117432 authors who have published 257986 publications receiving 11944239 citations. The organization is also known as: University of Minnesota, Twin Cities & University of Minnesota-Twin Cities.


Papers
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Journal ArticleDOI
TL;DR: RBD can be the heralding manifestation of Parkinson's disease in a substantial subgroup of older male RBD patients, and the pedunculopontine nucleus is implicate as a likely site of pathology in combined RBD-Parkinson's disease, based on experimental and theoretical considerations rather than on autopsy data.
Abstract: We report longitudinal data on a group of 29 male patients 50 years of age or older who were initially diagnosed as having idiopathic REM sleep behavior disorder (RBD) after extensive polysomnographic and neurologic evaluations. Thirty-eight percent (11/29) were eventually diagnosed as having a parkinsonian disorder (presumably Parkinson's disease) at a mean interval of 3.7 +/- 1.4 (SD) years after the diagnosis of RBD+, and at a mean interval of 12.7 +/- 7.3 years after the onset of RBD. To date, only 7% (2/29) of patients have developed any other neurologic disorder. At the time of RBD diagnosis, data from the RBD group with eventual Parkinson's disease (n = 11) and the current idiopathic RBD group (n = 16) were indistinguishable, with two exceptions: the RBD-Parkinson's disease group had a significantly elevated hourly index of periodic limb movements of non-REM sleep and an elevated REM sleep percentage. RBD was fully or substantially controlled with nightly clonazepam treatment in 89% (24/27) of patients in both groups. Thus, RBD can be the heralding manifestation of Parkinson's disease in a substantial subgroup of older male RBD patients. However, a number of presumed Parkinson's disease patients may eventually be diagnosed with multiple system atrophy (striatonigral degeneration subtype). Our findings indicate the importance of serial neurologic evaluations after RBD is diagnosed and implicate the pedunculopontine nucleus as a likely site of pathology in combined RBD-Parkinson's disease, based on experimental and theoretical considerations rather than on autopsy data.

1,058 citations

Journal ArticleDOI
TL;DR: Defining the role of NO in cerebral ischemia provides the rationale for new neuroprotective strategies based on modulation of NO production in the post-ischemic brain.

1,057 citations

Journal ArticleDOI
TL;DR: The epidemiologic literature on the relationship between vegetable and fruit consumption and human cancer at a variety of sites is reviewed systematically and it is concluded that consumption of higher levels of vegetables and fruit is associated consistently, although not universally, with a reduced risk of cancer at most sites.
Abstract: The epidemiologic literature on the relationship between vegetable and fruit consumption and human cancer at a variety of sites is reviewed systematically. A total of 13 ecologic studies, nine cohort studies, and 115 case-control studies are included. Cancer of all sites, cancers of lung, breast, colon, rectum, esophagus, larynx, oral cavity and pharynx, stomach, pancreas, prostate, bladder, ovary, endometrium, cervix, and thyroid, as well as mesothelioma and gestational trophoblastic disease, are considered. Relevant data from clinical trials, animal, and in vitro studies are included. It is concluded that consumption of higher levels of vegetables and fruit is associated consistently, although not universally, with a reduced risk of cancer at most sites. The association is most marked for epithelial cancers--particularly those of the alimentary and respiratory tracts--and, currently, is weak to nonexistent for hormone-related cancers. The association exists for a wide variety of vegetables and fruit with some suggestion that raw forms are associated most consistently with lower risk. Possible mechanisms by which vegetable and fruit intake might alter risk of cancer and possible adverse effects of vegetable and fruit consumption will be considered in Part II of this review.

1,056 citations

Book ChapterDOI
01 Jan 1993
TL;DR: In this paper, the authors focus on the fundamentals of poroelasticity, and discuss the formulation and analysis of coupled deformation-diffusion processes, within the framework of the Biot theory of pore elasticity.
Abstract: Publisher Summary This chapter focuses on fundamentals of poroelasticity. The presence of a freely moving fluid in a porous rock modifies its mechanical response. Two mechanisms play a key role in the interaction between the interstitial fluid and the porous rock: (i) an increase of pore pressure induces a dilation of the rock; and (ii) compression of the rock causes a rise of pore pressure, if the fluid is prevented from escaping the pore network. These coupled mechanisms bestow an apparent time-dependent character to the mechanical properties of the rock. If excess pore pressure, induced by compression of the rock, is allowed to dissipate through diffusive fluid mass transport, further deformation of the rock progressively takes place. The rock is more compliant under drained conditions than undrained ones. The chapter discusses the formulation and analysis of coupled deformation–diffusion processes, within the framework of the Biot theory of poroelasticity. The Biot model of a fluid-filled porous material is constructed on the conceptual model of a coherent solid skeleton and a freely moving pore fluid.

1,056 citations


Authors

Showing all 118112 results

NameH-indexPapersCitations
Walter C. Willett3342399413322
David J. Hunter2131836207050
David Miller2032573204840
Mark I. McCarthy2001028187898
Dennis W. Dickson1911243148488
David H. Weinberg183700171424
Eric Boerwinkle1831321170971
John C. Morris1831441168413
Aaron R. Folsom1811118134044
H. S. Chen1792401178529
Jie Zhang1784857221720
Jasvinder A. Singh1762382223370
Feng Zhang1721278181865
Gang Chen1673372149819
Hongfang Liu1662356156290
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023200
20221,176
202111,903
202011,807
201910,984
201810,367