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Institution

University of Minnesota

EducationMinneapolis, Minnesota, United States
About: University of Minnesota is a education organization based out in Minneapolis, Minnesota, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 117432 authors who have published 257986 publications receiving 11944239 citations. The organization is also known as: University of Minnesota, Twin Cities & University of Minnesota-Twin Cities.


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Journal ArticleDOI
Andrew V. Biankin1, Andrew V. Biankin2, Andrew V. Biankin3, Nicola Waddell4, Karin S. Kassahn4, Marie-Claude Gingras5, Lakshmi Muthuswamy6, Amber L. Johns3, David Miller4, Peter Wilson4, Ann-Marie Patch4, Jianmin Wu3, David K. Chang1, David K. Chang3, David K. Chang2, Mark J. Cowley3, Brooke Gardiner4, Sarah Song4, Ivon Harliwong4, Senel Idrisoglu4, Craig Nourse4, Ehsan Nourbakhsh4, Suzanne Manning4, Shivangi Wani4, Milena Gongora4, Marina Pajic3, Christopher J. Scarlett7, Christopher J. Scarlett3, Anthony J. Gill8, Anthony J. Gill3, Anthony J. Gill9, Andreia V. Pinho3, Ilse Rooman3, Matthew J. Anderson4, Oliver Holmes4, Conrad Leonard4, Darrin Taylor4, Scott Wood4, Qinying Xu4, Katia Nones4, J. Lynn Fink4, Angelika N. Christ4, Timothy J. C. Bruxner4, Nicole Cloonan4, Gabriel Kolle10, Felicity Newell4, Mark Pinese3, R. Scott Mead3, R. Scott Mead11, Jeremy L. Humphris3, Warren Kaplan3, Marc D. Jones3, Emily K. Colvin3, Adnan Nagrial3, Emily S. Humphrey3, Angela Chou11, Angela Chou3, Venessa T. Chin3, Lorraine A. Chantrill3, Amanda Mawson3, Jaswinder S. Samra8, James G. Kench12, James G. Kench9, James G. Kench3, Jessica A. Lovell3, Roger J. Daly3, Neil D. Merrett9, Neil D. Merrett2, Christopher W. Toon3, Krishna Epari13, Nam Q. Nguyen14, Andrew Barbour4, Nikolajs Zeps15, Nipun Kakkar5, Fengmei Zhao5, Yuan Qing Wu5, Min Wang5, Donna M. Muzny5, William E. Fisher5, F. Charles Brunicardi16, Sally E. Hodges5, Jeffrey G. Reid5, Jennifer Drummond5, Kyle Chang5, Yi Han5, Lora Lewis5, Huyen Dinh5, Christian J. Buhay5, Timothy Beck6, Lee Timms6, Michelle Sam6, Kimberly Begley6, Andrew M.K. Brown6, Deepa Pai6, Ami Panchal6, Nicholas Buchner6, Richard de Borja6, Robert E. Denroche6, Christina K. Yung6, Stefano Serra17, Nicole Onetto6, Debabrata Mukhopadhyay18, Ming-Sound Tsao17, Patricia Shaw17, Gloria M. Petersen18, Steven Gallinger17, Steven Gallinger19, Ralph H. Hruban20, Anirban Maitra20, Christine A. Iacobuzio-Donahue20, Richard D. Schulick20, Christopher L. Wolfgang20, Richard A. Morgan20, Rita T. Lawlor, Paola Capelli21, Vincenzo Corbo, Maria Scardoni21, Giampaolo Tortora, Margaret A. Tempero22, Karen M. Mann23, Nancy A. Jenkins23, Pedro A. Perez-Mancera24, David J. Adams25, David A. Largaespada26, Lodewyk F. A. Wessels27, Alistair G. Rust25, Lincoln Stein6, David A. Tuveson24, Neal G. Copeland23, Elizabeth A. Musgrove1, Elizabeth A. Musgrove3, Aldo Scarpa21, James R. Eshleman20, Thomas J. Hudson6, Robert L. Sutherland3, Robert L. Sutherland1, David A. Wheeler5, John V. Pearson4, John Douglas Mcpherson6, Richard A. Gibbs5, Sean M. Grimmond4 
15 Nov 2012-Nature
TL;DR: It is found that frequent and diverse somatic aberrations in genes described traditionally as embryonic regulators of axon guidance, particularly SLIT/ROBO signalling, are also evident in murine Sleeping Beauty transposon-mediated somatic mutagenesis models of pancreatic cancer, providing further supportive evidence for the potential involvement ofAxon guidance genes in pancreatic carcinogenesis.
Abstract: Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively accrued clinical cohort (n = 142) of early (stage I and II) sporadic pancreatic ductal adenocarcinoma. Detailed analysis of 99 informative tumours identified substantial heterogeneity with 2,016 non-silent mutations and 1,628 copy-number variations. We define 16 significantly mutated genes, reaffirming known mutations (KRAS, TP53, CDKN2A, SMAD4, MLL3, TGFBR2, ARID1A and SF3B1), and uncover novel mutated genes including additional genes involved in chromatin modification (EPC1 and ARID2), DNA damage repair (ATM) and other mechanisms (ZIM2, MAP2K4, NALCN, SLC16A4 and MAGEA6). Integrative analysis with in vitro functional data and animal models provided supportive evidence for potential roles for these genetic aberrations in carcinogenesis. Pathway-based analysis of recurrently mutated genes recapitulated clustering in core signalling pathways in pancreatic ductal adenocarcinoma, and identified new mutated genes in each pathway. We also identified frequent and diverse somatic aberrations in genes described traditionally as embryonic regulators of axon guidance, particularly SLIT/ROBO signalling, which was also evident in murine Sleeping Beauty transposon-mediated somatic mutagenesis models of pancreatic cancer, providing further supportive evidence for the potential involvement of axon guidance genes in pancreatic carcinogenesis.

1,752 citations

Journal ArticleDOI
TL;DR: The authors discuss the cognitive and affective processes that may mediate the influence of framed information on judgment and behavior and the relative effectiveness of gain-framing or loss-framed appeals.
Abstract: Health-relevant communications can be framed in terms of the benefits (gains) or costs (losses) associated with a particular behavior, and the framing of such persuasive messages influences health decision making. Although to ask people to consider a health issue in terms of associated costs is considered an effective way to motivate behavior, empirical findings are inconsistent. In evaluating the effectiveness of framed health messages, investigators must appreciate the context in which health-related decisions are made. The influence of framed information on decision making is contingent on people, first, internalizing the advocated frame and, then, on the degree to which performing a health behavior is perceived as risky. The relative effectiveness of gain-framed or loss-framed appeals depends, in part, on whether a behavior serves an illness-detecting or a health-affirming function. Finally, the authors discuss the cognitive and affective processes that may mediate the influence of framed information on judgment and behavior.

1,750 citations

Journal ArticleDOI
04 Jan 2008-Science
TL;DR: This comparison reveals genomic changes concomitant with the evolutionary movement to land, including a general increase in gene family complexity; loss of genes associated with aquatic environments; acquisition of genes for tolerating terrestrial stresses; and the development of the auxin and abscisic acid signaling pathways for coordinating multicellular growth and dehydration response.
Abstract: We report the draft genome sequence of the model moss Physcomitrella patens and compare its features with those of flowering plants, from which it is separated by more than 400 million years, and unicellular aquatic algae. This comparison reveals genomic changes concomitant with the evolutionary movement to land, including a general increase in gene family complexity; loss of genes associated with aquatic environments (e.g., flagellar arms); acquisition of genes for tolerating terrestrial stresses (e.g., variation in temperature and water availability); and the development of the auxin and abscisic acid signaling pathways for coordinating multicellular growth and dehydration response. The Physcomitrella genome provides a resource for phylogenetic inferences about gene function and for experimental analysis of plant processes through this plant's unique facility for reverse genetics.

1,749 citations

Journal ArticleDOI
TL;DR: IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances.
Abstract: It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances.

1,745 citations

Journal ArticleDOI
01 Jun 2006-Nature
TL;DR: It is found that greater numbers of plant species led to greater temporal stability of ecosystem annual aboveground plant production and the reliable, efficient and sustainable supply of some foods, fuels and ecosystem services can be enhanced by the use of biodiversity.
Abstract: Human-driven ecosystem simplification has highlighted questions about how the number of species in an ecosystem influences its functioning. Although biodiversity is now known to affect ecosystem productivity, its effects on stability are debated. Here we present a long-term experimental field test of the diversity-stability hypothesis. During a decade of data collection in an experiment that directly controlled the number of perennial prairie species, growing-season climate varied considerably, causing year-to-year variation in abundances of plant species and in ecosystem productivity. We found that greater numbers of plant species led to greater temporal stability of ecosystem annual aboveground plant production. In particular, the decadal temporal stability of the ecosystem, whether measured with intervals of two, five or ten years, was significantly greater at higher plant diversity and tended to increase as plots matured. Ecosystem stability was also positively dependent on root mass, which is a measure of perenniating biomass. Temporal stability of the ecosystem increased with diversity, despite a lower temporal stability of individual species, because of both portfolio (statistical averaging) and overyielding effects. However, we found no evidence of a covariance effect. Our results indicate that the reliable, efficient and sustainable supply of some foods (for example, livestock fodder), biofuels and ecosystem services can be enhanced by the use of biodiversity.

1,743 citations


Authors

Showing all 118112 results

NameH-indexPapersCitations
Walter C. Willett3342399413322
David J. Hunter2131836207050
David Miller2032573204840
Mark I. McCarthy2001028187898
Dennis W. Dickson1911243148488
David H. Weinberg183700171424
Eric Boerwinkle1831321170971
John C. Morris1831441168413
Aaron R. Folsom1811118134044
H. S. Chen1792401178529
Jie Zhang1784857221720
Jasvinder A. Singh1762382223370
Feng Zhang1721278181865
Gang Chen1673372149819
Hongfang Liu1662356156290
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023200
20221,176
202111,903
202011,807
201910,984
201810,367