scispace - formally typeset
Search or ask a question

Showing papers by "University of Missouri published in 2005"


Journal ArticleDOI
TL;DR: The results reveal that happiness is associated with and precedes numerous successful outcomes, as well as behaviors paralleling success, and the evidence suggests that positive affect may be the cause of many of the desirable characteristics, resources, and successes correlated with happiness.
Abstract: Numerous studies show that happy individuals are successful across multiple life domains, including marriage, friendship, income, work performance, and health. The authors suggest a conceptual model to account for these findings, arguing that the happiness-success link exists not only because success makes people happy, but also because positive affect engenders success. Three classes of evidence--crosssectional, longitudinal, and experimental--are documented to test their model. Relevant studies are described and their effect sizes combined meta-analytically. The results reveal that happiness is associated with and precedes numerous successful outcomes, as well as behaviors paralleling success. Furthermore, the evidence suggests that positive affect--the hallmark of well-being--may be the cause of many of the desirable characteristics, resources, and successes correlated with happiness. Limitations, empirical issues, and important future research questions are discussed.

5,713 citations


Journal ArticleDOI
TL;DR: In this paper, the authors propose that a person's chronic happiness level is governed by three major factors: a genetically determined set point for happiness, happiness-relevant circumstantial factors, and happiness relevant activities and practices.
Abstract: The pursuit of happiness is an important goal for many people. However, surprisingly little scientific research has focused on the question of how happiness can be increased and then sustained, probably because of pessimism engendered by the concepts of genetic determinism and hedonic adaptation. Nevertheless, emerging sources of optimism exist regarding the possibility of permanent increases in happiness. Drawing on the past well-being literature, the authors propose that a person's chronic happiness level is governed by 3 major factors: a genetically determined set point for happiness, happiness-relevant circumstantial factors, and happiness-relevant activities and practices. The authors then consider adaptation and dynamic processes to show why the activity category offers the best opportunities for sustainably increasing happiness. Finally, existing research is discussed in support of the model, including 2 preliminary happiness-increasing interventions.

2,616 citations


Journal ArticleDOI
TL;DR: It is the recommendation of this committee that patients with soft-tissue infection be distinguished by signs and symptoms of systemic toxicity (e.g., fever or hypothermia, tachycardia [heart rate,] and so on).
Abstract: EXECUTIVE SUMMARYSoft-tissue infections are common, generally of mild tomodest severity, and are easily treated with a variety ofagents. An etiologic diagnosis of simple cellulitis is fre-quently difficult and generally unnecessary for patientswith mild signs and symptoms of illness. Clinical as-sessment of the severity of infection is crucial, and sev-eral classification schemes and algorithms have beenproposed to guide the clinician [1]. However, mostclinical assessments have been developed from eitherretrospective studies or from an author’s own “clinicalexperience,” illustrating the need for prospectivestudieswith defined measurements of severity coupled to man-agement issues and outcomes.Until then, it is the recommendation of this com-mittee that patients with soft-tissue infection accom-panied by signs and symptoms of systemic toxicity (e.g.,fever or hypothermia, tachycardia [heart rate,

2,008 citations


Journal ArticleDOI
29 Apr 2005-Science
TL;DR: The authors of as mentioned in this paper developed a comprehensive database of >37,000 river restoration projects across the United States, which are intended to enhance water quality, manage riparian zones, improve in-stream habitat, allow fish passage, and stabilize stream banks.
Abstract: The authors of this Policy Forum developed a comprehensive database of >37,000 river restoration projects across the United States. Such projects have increased exponentially over the past decade with more than a billion dollars spent annually since 1990. Most are intended to enhance water quality, manage riparian zones, improve in-stream habitat, allow fish passage, and stabilize stream banks. Only 10% of project records document any form of project monitoring, and little if any of this information is either appropriate or available for assessing the ecological effectiveness of restoration activities.

1,693 citations


Journal ArticleDOI
TL;DR: The hypothesis that prenatal phthalate exposure at environmental levels can adversely affect male reproductive development in humans is supported.
Abstract: Prenatal phthalate exposure impairs testicular function and shortens anogenital distance (AGD) in male rodents. We present data from the first study to examine AGD and other genital measurements in relation to prenatal phthalate exposure in humans. A standardized measure of AGD was obtained in 134 boys 2–36 months of age. AGD was significantly correlated with penile volume (R = 0.27, p = 0.001) and the proportion of boys with incomplete testicular descent (R = 0.20, p = 0.02). We defined the anogenital index (AGI) as AGD divided by weight at examination [AGI = AGD/weight (mm/kg)] and calculated the age-adjusted AGI by regression analysis. We examined nine phthalate monoester metabolites, measured in prenatal urine samples, as predictors of age-adjusted AGI in regression and categorical analyses that included all participants with prenatal urine samples (n = 85). Urinary concentrations of four phthalate metabolites [monoethyl phthalate (MEP), mono-n-butyl phthalate (MBP), monobenzyl phthalate (MBzP), and monoisobutyl phthalate (MiBP)] were inversely related to AGI. After adjusting for age at examination, p-values for regression coefficients ranged from 0.007 to 0.097. Comparing boys with prenatal MBP concentration in the highest quartile with those in the lowest quartile, the odds ratio for a shorter than expected AGI was 10.2 (95% confidence interval, 2.5 to 42.2). The corresponding odds ratios for MEP, MBzP, and MiBP were 4.7, 3.8, and 9.1, respectively (all p-values < 0.05). We defined a summary phthalate score to quantify joint exposure to these four phthalate metabolites. The age-adjusted AGI decreased significantly with increasing phthalate score (p-value for slope = 0.009). The associations between male genital development and phthalate exposure seen here are consistent with the phthalate-related syndrome of incomplete virilization that has been reported in prenatally exposed rodents. The median concentrations of phthalate metabolites that are associated with short AGI and incomplete testicular descent are below those found in one-quarter of the female population of the United States, based on a nationwide sample. These data support the hypothesis that prenatal phthalate exposure at environmental levels can adversely affect male reproductive development in humans.

1,507 citations


Journal ArticleDOI
TL;DR: In this paper, the authors propose five criteria for measuring success of river restoration, with emphasis on an ecological perspective, and suggest standards of evaluation for each of the five criteria and provide examples of suitable indicators.
Abstract: Summary 1. Increasingly, river managers are turning from hard engineering solutions to ecologically based restoration activities in order to improve degraded waterways. River restoration projects aim to maintain or increase ecosystem goods and services while protecting downstream and coastal ecosystems. There is growing interest in applying river restoration techniques to solve environmental problems, yet little agreement exists on what constitutes a successful river restoration effort. 2. We propose five criteria for measuring success, with emphasis on an ecological perspective. First, the design of an ecological river restoration project should be based on a specified guiding image of a more dynamic, healthy river that could exist at the site. Secondly, the river’s ecological condition must be measurably improved. Thirdly, the river system must be more self-sustaining and resilient to external perturbations so that only minimal follow-up maintenance is needed. Fourthly, during the construction phase, no lasting harm should be inflicted on the ecosystem. Fifthly, both pre- and postassessment must be completed and data made publicly available. 3. Determining if these five criteria have been met for a particular project requires development of an assessment protocol. We suggest standards of evaluation for each of the five criteria and provide examples of suitable indicators. 4. Synthesis and applications . Billions of dollars are currently spent restoring streams and rivers, yet to date there are no agreed upon standards for what constitutes ecologically beneficial stream and river restoration. We propose five criteria that must be met for a river restoration project to be considered ecologically successful. It is critical that the broad restoration community, including funding agencies, practitioners and citizen restoration groups, adopt criteria for defining and assessing ecological success in restoration. Standards are needed because progress in the science and practice of river restoration has been hampered by the lack of agreed upon criteria for judging ecological success. Without well-accepted criteria that are ultimately supported by funding and implementing agencies, there is little incentive for practitioners to assess and report restoration outcomes. Improving methods and weighing the ecological benefits of various restoration approaches require organized national-level reporting systems.

1,450 citations


Journal ArticleDOI
TL;DR: A new model called possibilistic-fuzzy c-means (PFCM) model, which solves the noise sensitivity defect of FCM, overcomes the coincident clusters problem of PCM and eliminates the row sum constraints of FPCM.
Abstract: In 1997, we proposed the fuzzy-possibilistic c-means (FPCM) model and algorithm that generated both membership and typicality values when clustering unlabeled data. FPCM constrains the typicality values so that the sum over all data points of typicalities to a cluster is one. The row sum constraint produces unrealistic typicality values for large data sets. In this paper, we propose a new model called possibilistic-fuzzy c-means (PFCM) model. PFCM produces memberships and possibilities simultaneously, along with the usual point prototypes or cluster centers for each cluster. PFCM is a hybridization of possibilistic c-means (PCM) and fuzzy c-means (FCM) that often avoids various problems of PCM, FCM and FPCM. PFCM solves the noise sensitivity defect of FCM, overcomes the coincident clusters problem of PCM and eliminates the row sum constraints of FPCM. We derive the first-order necessary conditions for extrema of the PFCM objective function, and use them as the basis for a standard alternating optimization approach to finding local minima of the PFCM objective functional. Several numerical examples are given that compare FCM and PCM to PFCM. Our examples show that PFCM compares favorably to both of the previous models. Since PFCM prototypes are less sensitive to outliers and can avoid coincident clusters, PFCM is a strong candidate for fuzzy rule-based system identification.

1,118 citations


Journal ArticleDOI
TL;DR: It is proposed that a new risk assessment for BPA is needed based on the extensive new literature reporting adverse effects in animals at doses below the current reference dose, and the high rate of leaching of BPA from food and beverage containers, leading to widespread human exposure.
Abstract: Bisphenol A (BPA) is the monomer used to manufacture polycarbonate plastic, the resin lining of cans, and other products, with global capacity in excess of 6.4 billion lb/year. Because the ester bonds in these BPA-based polymers are subject to hydrolysis, leaching of BPA has led to widespread human exposure. A recent report prepared by the Harvard Center for Risk Analysis and funded by the American Plastics Council concluded that evidence for low-dose effects of BPA is weak on the basis of a review of only 19 studies; the report was issued after a delay of 2.5 years. A current comprehensive review of the literature reveals that the opposite is true. As of December 2004, there were 115 published in vivo studies concerning low-dose effects of BPA, and 94 of these report significant effects. In 31 publications with vertebrate and invertebrate animals, significant effects occurred below the predicted “safe” or reference dose of 50 μg/kg/day BPA. An estrogenic mode of action of BPA is confirmed by in vitro experiments, which describe disruption of cell function at 10−12 M or 0.23 ppt. Nonetheless, chemical manufacturers continue to discount these published findings because no industry-funded studies have reported significant effects of low doses of BPA, although > 90% of government-funded studies have reported significant effects. Some industry-funded studies have ignored the results of positive controls, and many studies reporting no significant effects used a strain of rat that is inappropriate for the study of estrogenic responses. We propose that a new risk assessment for BPA is needed based on a) the extensive new literature reporting adverse effects in animals at doses below the current reference dose; b) the high rate of leaching of BPA from food and beverage containers, leading to widespread human exposure; c) reports that the median BPA level in human blood and tissues, including in human fetal blood, is higher than the level that causes adverse effects in mice; and d) recent epidemiologic evidence that BPA is related to disease in women.

1,095 citations


Journal ArticleDOI
TL;DR: It is argued that the critical aspect of successful WM measures is that rehearsal and grouping processes are prevented, allowing a clearer estimate of how many separate chunks of information the focus of attention circumscribes at once.

1,051 citations


Journal ArticleDOI
TL;DR: Qualitative issues are raised and recommendations for optimal methods of startle blink electromyographic (EMG) response elicitation, recording, quantification, and reporting are presented.
Abstract: The human startle response is a sensitive, noninvasive measure of central nervous system activity that is currently used in a wide variety of research and clinical settings. In this article, we raise methodological issues and present recommendations for optimal methods of startle blink electromyographic (EMG) response elicitation, recording, quantification, and reporting. It is hoped that this report will foster more methodological validity and reliability in research using the startle response, as well as increase the detail with which relevant methodology is reported in publications using this measure.

1,040 citations


Journal ArticleDOI
TL;DR: In this paper, the authors estimate ADA (Americans for Democratic Action) scores for major media outlets such as the New York Times, USA Today, Fox News Special Report, and all three network television news shows.
Abstract: In this paper we estimate ADA (Americans for Democratic Action) scores for major media outlets such as the New York Times, USA Today, Fox News Special Report, and all three network television news shows. Our estimates allow us to answer such questions as Is the average article in the New York Times more liberal than the average speech by Tom Daschle? or Is the average story on Fox News more conservative than the average speech by Bill Frist? To compute our measure, we count the times that a media outlet cites various think tanks and other policy groups. We compare this with the times that members of Congress cite the same groups in their speeches on the floor of the House and Senate. By comparing the citation patterns we construct an ADA score. As a simplified example, imagine that there were only two think tanks, and suppose that the New York Times cited the first think tank twice as often as the second. Our method asks: What is the typical ADA score of members of Congress who exhibit the same frequency (2:1) in their speeches? This is the score that we would assign to the New York Times. Our results show a strong liberal bias. All of the news outlets except Fox News Special Report and the Washington Times received a score to the left of the average member of Congress. Consistent with many conservative critics, CBS Evening News and the New York Times received a score far left of center. Outlets such as USA Today, NPRs Morning Edition, NBCs Nightly News and ABCs World News Tonight were moderately left. The most centrist outlets (but still left-leaning) by our measure were the Newshour with Jim Lehrer, CNNs NewsNight with Aaron Brown, and ABCs Good Morning America. Fox News Special Report, while right of center, was closer to the center than any of the three major networks evening news broadcasts. All of our findings refer strictly to the news stories of the outlets. That is, we omitted editorials, book reviews, and letters to the editor from our sample.

Journal ArticleDOI
TL;DR: In this paper, a new reaction pathway for converting glycerol to propylene glycol via an intermediate was validated by isolating the acetol intermediate, and the results showed that the yield of glycerols increased with decreasing water content.
Abstract: Hydrogenolysis of glycerol to propylene glycol was performed using nickel, palladium, platinum, copper, and copper-chromite catalysts. The effects of temperature, hydrogen pressure, initial water content, choice of catalyst, catalyst reduction temperature, and the amount of catalyst were evaluated. At temperatures above 200 °C and hydrogen pressure of 200 psi, the selectivity to propylene glycol decreased due to excessive hydrogenolysis of the propylene glycol. At 200 psi and 200 °C the pressures and temperaures were significantly lower than those reported in the literature while maintaining high selectivities and good conversions. The yield of propylene glycol increased with decreasing water content. A new reaction pathway for converting glycerol to propylene glycol via an intermediate was validated by isolating the acetol intermediate.

Journal ArticleDOI
TL;DR: The appearance of differentiated regions as assessed morphologically, biochemically, and immunohistochemically was markedly reduced under hypoxic conditions, and hES cell growth under hypoxia provided enhanced formation of embryoid bodies.
Abstract: Early-stage mammalian embryos develop in a low O2 environment (hypoxia). hES cells, however, are generally cultured under an atmosphere of 21% O2 (normoxia), under which conditions they tend to differentiate spontaneously. Such conditions may not be the most suitable, therefore, for hES cell propagation. Here we have tested two hypotheses. The first hypothesis was that hES cells would grow as well under hypoxic as under normoxic conditions. The second hypothesis was that hypoxic culture would reduce the amount of spontaneous cell differentiation that occurs in hES colonies. Both hypotheses proved to be correct. Cells proliferated as well under 3% and 5% O2 as they did under 21% O2, and growth was only slightly reduced at 1% O2. The appearance of differentiated regions as assessed morphologically, biochemically (by the production of human chorionic gonadotropin and progesterone), and immunohistochemically (by the loss of stage-specific embryonic antigen-4 and Oct-4 and gain of stage-specific embryonic antigen-1 marker expression) was markedly reduced under hypoxic conditions. In addition, hES cell growth under hypoxia provided enhanced formation of embryoid bodies. Hypoxic culture would appear to be necessary to maintain full pluripotency of hES cells.

Journal ArticleDOI
TL;DR: In this article, the authors explored the possibility of the existence of a common scale, which can be used to gauge bond strength between various surfaces and found that the changes in wettability of surfaces owing to various levels of plasma exposure can be a useful parameter to gauge the bond strength.
Abstract: An issue in microfabrication of the fluidic channels in glass/poly (dimethyl siloxane) (PDMS) is the absence of a well-defined study of the bonding strength between the surfaces making up these channels. Although most of the research papers mention the use of oxygen plasma for developing chemical (siloxane) bonds between the participating surfaces, yet they only define a certain set of parameters, tailored to a specific setup. An important requirement of all the microfluidics/biosensors industry is the development of a general regime, which defines a systematic method of gauging the bond strength between the participating surfaces in advance by correlation to a common parameter. This enhances the reliability of the devices and also gives a structured approach to its future large-scale manufacturing. In this paper, we explore the possibility of the existence of a common scale, which can be used to gauge bond strength between various surfaces. We find that the changes in wettability of surfaces owing to various levels of plasma exposure can be a useful parameter to gauge the bond strength. We obtained a good correlation between contact angle of deionized water (a direct measure of wettability) on the PDMS and glass surfaces based on various dosages or oxygen plasma treatment. The exposure was done first in an inductively coupled high-density (ICP) plasma system and then in plasma enhanced chemical vapor deposition (PECVD) system. This was followed by the measurement of bond strength by use or the standardized blister test.

Journal Article
TL;DR: RNA interference is an evolutionarily conserved mechanism that uses short antisense RNAs that are generated by 'dicing' dsRNA precursors to target corresponding mRNAs for cleavage to facilitate the directed silencing of specific genomic regions.
Abstract: | RNA interference (RNAi) is an evolutionarily conserved mechanism that uses short antisense RNAs that are generated by 'dicing' dsRNA precursors to target corresponding mRNAs for cleavage. However, recent developments have revealed that there is also extensive involvement of RNAi-related processes in regulation at the genome level. dsRNA and proteins of the RNAi machinery can direct epigenetic alterations to homologous DNA sequences to induce transcriptional gene silencing or, in extreme cases, DNA elimination. Furthermore, in some organisms RNAi silences unpaired DNA regions during meiosis. These mechanisms facilitate the directed silencing of specific genomic regions.

Journal ArticleDOI
TL;DR: RNA interference (RNAi) is an evolutionarily conserved mechanism that uses short antisense RNAs that are generated by 'dicing' dsRNA precursors to target corresponding mRNAs for cleavage as discussed by the authors.
Abstract: RNA interference (RNAi) is an evolutionarily conserved mechanism that uses short antisense RNAs that are generated by 'dicing' dsRNA precursors to target corresponding mRNAs for cleavage. However, recent developments have revealed that there is also extensive involvement of RNAi-related processes in regulation at the genome level. dsRNA and proteins of the RNAi machinery can direct epigenetic alterations to homologous DNA sequences to induce transcriptional gene silencing or, in extreme cases, DNA elimination. Furthermore, in some organisms RNAi silences unpaired DNA regions during meiosis. These mechanisms facilitate the directed silencing of specific genomic regions.

Journal ArticleDOI
01 Jan 2005-Chest
TL;DR: None of the pooled metaanalyses showed a significant difference between devices in any efficacy outcome in any patient group for each of the clinical settings that was investigated.

Book
18 Apr 2005
TL;DR: In this article, the physics of the interacting electron liquid in a broad variety of systems, including metals, semiconductors, artificial nano-structures, atoms and molecules, is discussed.
Abstract: Modern electronic devices and novel materials often derive their extraordinary properties from the intriguing, complex behavior of large numbers of electrons forming what is known as an electron liquid. This book provides an in-depth introduction to the physics of the interacting electron liquid in a broad variety of systems, including metals, semiconductors, artificial nano-structures, atoms and molecules. One, two and three dimensional systems are treated separately and in parallel. Different phases of the electron liquid, from the Landau Fermi liquid to the Wigner crystal, from the Luttinger liquid to the quantum Hall liquid are extensively discussed. Both static and time-dependent density functional theory are presented in detail. Although the emphasis is on the development of the basic physical ideas and on a critical discussion of the most useful approximations, the formal derivation of the results is highly detailed and based on the simplest, most direct methods.

Journal ArticleDOI
TL;DR: This paper found that firms in industries with greater external financing needs have higher voluntary disclosure levels, and that an expanded disclosure policy for these firms leads to a lower cost of both debt and equity capital.
Abstract: Prior research predicts that firms reliant on external financing are more likely to undertake a higher level of disclosure, and a higher disclosure level should, in turn, lead to a lower cost of external financing. This paper tests these predictions outside the United States where alternative legal and financial systems could mitigate the effectiveness of such disclosures and, comprehensively, examines both disclosure incentives and disclosure consequences on cost of capital for a common set of firms. Using a sample from 34 countries, we find that firms in industries with greater external financing needs have higher voluntary disclosure levels, and that an expanded disclosure policy for these firms leads to a lower cost of both debt and equity capital. Crosscountry differences in legal and financial systems affect observed disclosure levels in predicted ways. However, a surprising result in the study is that voluntary disclosure incentives appear to operate independently of country‐level factors, which su...

Journal ArticleDOI
TL;DR: It is suggested that PTEN gene testing be considered for patients with autistic behaviour and extreme macrocephaly, and the gene findings may impact on recurrence risks as well as medical management for the patient.
Abstract: The genetic aetiology of autism remains elusive. Occasionally, individuals with Cowden syndrome (a cancer syndrome) and other related hamartoma disorders such as Bannayan-Riley-Ruvalcaba syndrome, Proteus syndrome, and Proteus-like conditions, are characterised by germline PTEN mutations, and may have neurobehavioural features resembling autism as well as overgrowth and macrocephaly. Therefore, we undertook PTEN gene mutation analysis in 18 subjects mainly prospectively ascertained with autism spectrum disorder and macrocephaly. Of these 18 autistic subjects (13 males and five females; ages 3.1–18.4 years) with a head circumference range from 2.5 to 8.0 standard deviations above the mean, three males (17%) carried germline PTEN mutations. These three probands had previously undescribed PTEN mutations: H93R (exon 4), D252G (exon 7), and F241S (exon 7). They had the larger head circumference measurements amongst all our study subjects. The three residues altered in our patients were highly evolutionarily conserved. We suggest that PTEN gene testing be considered for patients with autistic behaviour and extreme macrocephaly. The gene findings may impact on recurrence risks as well as medical management for the patient.

Journal ArticleDOI
TL;DR: The Sarbanes-Oxley Act of 2002 (SOX) as mentioned in this paper has been criticised for not solving the audit profession's alleged problems and may have serious unintended negative consequences.
Abstract: The scrutiny auditing received following Enron's failure and the accounting scandals at Worldcom and other companies provides compelling evidence that auditing matters and is important. What is unclear, however, is whether auditing was sufficiently “broken” in the first place to warrant the radical reforms and changes effected by the Sarbanes‐Oxley Act of 2002 (SOX). While there have been some high profile corporate failures and accounting scandals, the number of demonstrated audit failures as evidenced by successful litigation or U.S. Securities and Exchange Commission (SEC) sanctions is quite small and approaches an annual failure rate of close to zero. In addition, our interpretation of the academic research suggests that many of the “solutions” embodied in SOX are not only unlikely to solve the profession's alleged problems; they may well have serious unintended negative consequences. So the disconnect is large between the scientific evidence on audit quality and institutional changes premised on the ...

Journal ArticleDOI
TL;DR: The authors investigated the structure of goal contents in a group of 1,854 undergraduates from 15 cultures around the world and suggested that the 11 types of goals the authors assessed were consistently organized in a circumplex fashion.
Abstract: The authors investigated the structure of goal contents in a group of 1,854 undergraduates from 15 cultures around the world. Results suggested that the 11 types of goals the authors assessed were consistently organized in a circumplex fashion across the 15 cultures. The circumplex was well described by positioning 2 primary dimensions underlying the goals: intrinsic (e.g., self-acceptance, affiliation) versus extrinsic (e.g., financial success, image) and self-transcendent (e.g., spirituality) versus physical (e.g., hedonism). The circumplex model of goal contents was also quite similar in both wealthier and poorer nations, although there were some slight cross-cultural variations. The relevance of these results for several theories of motivation and personality are discussed.

Journal ArticleDOI
TL;DR: Arf6 and arf8 single mutants and sesquimutants had delayed stamen development and decreased fecundity, indicating that ARF6 and ARF8 gene dosage affects timing of flower maturation quantitatively.
Abstract: Pollination in flowering plants requires that anthers release pollen when the gynoecium is competent to support fertilization. We show that in Arabidopsis thaliana, two paralogous auxin response transcription factors, ARF6 and ARF8, regulate both stamen and gynoecium maturation. arf6 arf8 double-null mutant flowers arrested as infertile closed buds with short petals, short stamen filaments, undehisced anthers that did not release pollen and immature gynoecia. Numerous developmentally regulated genes failed to be induced. ARF6 and ARF8 thus coordinate the transition from immature to mature fertile flowers. Jasmonic acid (JA) measurements and JA feeding experiments showed that decreased jasmonate production caused the block in pollen release, but not the gynoecium arrest. The double mutant had altered auxin responsive gene expression. However, whole flower auxin levels did not change during flower maturation, suggesting that auxin might regulate flower maturation only under specific environmental conditions, or in localized organs or tissues of flowers. arf6 and arf8 single mutants and sesquimutants (homozygous for one mutation and heterozygous for the other) had delayed stamen development and decreased fecundity, indicating that ARF6 and ARF8 gene dosage affects timing of flower maturation quantitatively.

Journal ArticleDOI
TL;DR: In this article, the authors developed evidence for the validity and reliability of an English-language translation of the Oldenburg Burnout Inventory (OLBI) and assessed the characteristics of the OLBI using data from 2599 employees across two samples from the United States.
Abstract: While the most commonly employed burnout measure has been the Maslach Burnout Inventory (MBI), researchers have been troubled by some of the psychometric limitations of that scale (e.g. wording of the scale items) as well as the limited conceptualization of burnout upon which it is based. As a result, Demerouti et al. have developed an alternative measure of burnout, the Oldenburg Burnout Inventory (OLBI). The purpose of this paper is to develop evidence for the validity and reliability of an English-language translation of the OLBI. As such, this study is among the first validation studies of the OLBI, and the first to assess the characteristics of the OLBI an English-speaking sample. Using data from 2599 employees across two samples from the United States (a generalized sample of working adults and a sample of fire department employees), our preliminary multi-trait, multi-method (MTMM) and confirmatory factor analyses suggested that the OLBI may be a viable alternative to the Maslach Burnout In...

Journal ArticleDOI
TL;DR: In this article, the authors investigated the pricing of Big 5 industry leadership in the U.S. audit market using audit fee disclosures for the 2000-2001 fiscal years and the joint national city framework in Ferguson et al.
Abstract: The pricing of Big 5 industry leadership in the U.S. audit market is investigated using audit fee disclosures for the 2000–2001 fiscal years and the joint nationalcity framework in Ferguson et al. (2003). There is a significant fee premium of 19 percent on those engagements where Big 5 auditors are both the nationally top‐ranked auditor and the city‐level industry leader in the city where the client is headquartered, indicating that national and city‐specific industry leadership jointly affect auditor reputation and pricing. However, there is never a premium in any tests for auditors that are national industry leaders alone without also being city‐specific industry leaders, indicating that national leadership by itself does not result in a premium. The evidence is mixed with respect to city‐specific industry leaders alone that are not also national industry leaders. While there is a premium of 8 percent in the primary tests, this result is inconclusive as it does not hold in all sensitivity analyses.

Journal ArticleDOI
30 Jun 2005-Catena
TL;DR: In this article, the response of seven soil erosion models to a few basic precipitation and vegetation related parameters using common data from one humid and one semi-arid watershed was investigated, and the results suggest that there is a significant potential for climate change to increase global soil erosion rates unless offsetting conservation measures are taken.
Abstract: Global climate has changed over the past century. Precipitation amounts and intensities are increasing. In this study we investigated the response of seven soil erosion models to a few basic precipitation and vegetation related parameters using common data from one humid and one semi-arid watershed. Perturbations were made to inputs for rainfall intensities and amounts, and to ground surface cover and canopy cover. Principal results were that: soil erosion is likely to be more affected than runoff by changes in rainfall and cover, though both are likely to be significantly impacted; percent erosion and runoff will likely change more for each percent change in rainfall intensity and amount than to each percent change in either canopy or ground cover; changes in rainfall amount associated with changes in storm rainfall intensity will likely have a greater impact on runoff and erosion than simply changes in rainfall amount alone; changes in ground cover have a much greater impact on both runoff and erosion than changes in canopy cover alone. The results do not imply that future changes in rainfall will dominate over changes in land use, since land use changes can often be drastic. Given the types of precipitation changes that have occurred over the last century, and the expectations regarding changes over the next century, the results of this study suggest that there is a significant potential for climate change to increase global soil erosion rates unless offsetting conservation measures are taken.

Journal ArticleDOI
TL;DR: There is converging evidence that four major domains of personality are relevant to personality pathology: neuroticism/negative affectivity/emotional dysregulation; extraversion/positive emotionality; dissocial/antagonistic behavior; and constraint/compulsivity/conscientiousness.
Abstract: We review major categorical and dimensional models of personality pathology, highlighting advantages and disadvantages of these approaches. Several analytic and methodological approaches to the question of the categorical versus dimensional status of constructs are discussed, including taxometric analyses, latent class analyses, and multivariate genetic analyses. Based on our review, we advocate a dimensional approach to classifying personality pathology. There is converging evidence that four major domains of personality are relevant to personality pathology: neuroticism/negative affectivity/emotional dysregulation; extraversion/positive emotionality; dissocial/antagonistic behavior; and constraint/compulsivity/conscientiousness. Finally, we discuss how dimensional approaches might be integrated into the diagnostic system, as well as some of the major issues that must be addressed in order for dimensional approaches to gain wide acceptance.

Journal ArticleDOI
TL;DR: Arabidopsis lines carrying T-DNA insertions in AUXIN RESPONSE FACTOR1 (ARF1) and ARF2 genes are examined and it is found that ARF1 promotes transitions between multiple stages of Arabidopsis development, and an arf1 mutation increased transcription of Aux/IAA genes in Arabicidopsis flowers, supporting previous biochemical studies that indicated that ARFs are a transcriptional repressor.
Abstract: In plants, both endogenous mechanisms and environmental signals regulate developmental transitions such as seed germination, induction of flowering, leaf senescence and shedding of senescent organs. Auxin response factors (ARFs) are transcription factors that mediate responses to the plant hormone auxin. We have examined Arabidopsis lines carrying T-DNA insertions in AUXIN RESPONSE FACTOR1 (ARF1) and ARF2 genes. We found that ARF2 promotes transitions between multiple stages of Arabidopsis development. arf2 mutant plants exhibited delays in several processes related to plant aging, including initiation of flowering, rosette leaf senescence, floral organ abscission and silique ripening. ARF2 expression was induced in senescing leaves. ARF2 regulated leaf senescence and floral organ abscission independently of the ethylene and cytokinin response pathways. arf1 mutations enhanced many arf2 phenotypes, indicating that ARF1 acts in a partially redundant manner with ARF2. However, unlike arf2 mutations, an arf1 mutation increased transcription of Aux/IAA genes in Arabidopsis flowers, supporting previous biochemical studies that indicated that ARF1 is a transcriptional repressor. Two other ARF genes, NPH4/ARF7 and ARF19, were also induced by senescence, and mutations in these genes enhanced arf2 phenotypes. NPH4/ARF7 and ARF19 function as transcriptional activators, suggesting that auxin may control senescence in part by activating gene expression.

Journal ArticleDOI
TL;DR: This chapter focuses on recent developments in the etiology of alcohol use disorders and ways in which genetic, environmental, psychopharmacological, and personological literatures can inform one another.
Abstract: Pathological alcohol use is a complex and costly problem. This chapter focuses on recent developments in the etiology of alcohol use disorders. Literature is reviewed from the fields of epidemiology, genetics, personality, neuropsychology, parenting, and social influences. In addition, theoretical models that describe pathways to the development of alcohol use disorders are presented. Particular emphasis is given to ways in which genetic, environmental, psychopharmacological, and personological literatures can inform one another.

Journal ArticleDOI
TL;DR: In this paper, a distinction is made between two groups of high-status youth: those who are genuinely well liked by their peers and engage in predominantly prosocial behaviors and those who were seen as popular by their friends but are not necessarily well liked.
Abstract: Much research has focused on youth who are rejected by peers; who engage in negative behavior, including aggression; and who are at risk for adjustment problems. Recently, researchers have become increasingly interested in high-status youth. A distinction is made between two groups of high-status youth: those who are genuinely well liked by their peers and engage in predominantly prosocial behaviors and those who are seen as popular by their peers but are not necessarily well liked. The latter group of youth is well known, socially central, and emulated, but displays a mixed profile of prosocial as well as aggressive and manipulative behaviors. Research now needs to address the distinctive characteristics of these two groups and their developmental precursors and consequences. Of particular interest are high-status and socially powerful aggressors and their impact on their peers. The heterogeneity of high-status youth complicates the understanding of the social dynamics of the peer group, but will lead to...