University of Missouri

About: University of Missouri is a education organization based out in Columbia, Missouri, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 41427 authors who have published 83598 publications receiving 2911437 citations. The organization is also known as: Mizzou & Missouri-Columbia.

American College of Sports Medicine roundtable. The physiological and health effects of oral creatine supplementation.

Abstract: Creatine (Cr) supplementation has become a common practice among professional, elite, collegiate, amateur, and recreational athletes with the expectation of enhancing exercise performance. Research indicates that Cr supplementation can increase muscle phosphocreatine (PCr) content, but not in all individuals. A high dose of 20 g x d(-1) that is common to many research studies is not necessary, as 3 g x d(-1) will achieve the same increase in PCr given time. Coincident ingestion of carbohydrate with Cr may increase muscle uptake; however, the procedure requires a large amount of carbohydrate. Exercise performance involving short periods of extremely powerful activity can be enhanced, especially during repeated bouts of activity. This is in keeping with the theoretical importance of an elevated PCr content in skeletal muscle. Cr supplementation does not increase maximal isometric strength, the rate of maximal force production, nor aerobic exercise performance. Most of the evidence has been obtained from healthy young adult male subjects with mixed athletic ability and training status. Less research information is available related to the alterations due to age and gender. Cr supplementation leads to weight gain within the first few days, likely due to water retention related to Cr uptake in the muscle. Cr supplementation is associated with an enhanced accrual of strength in strength-training programs, a response not independent from the initial weight gain, but may be related to a greater volume and intensity of training that can be achieved. There is no definitive evidence that Cr supplementation causes gastrointestinal, renal, and/or muscle cramping complications. The potential acute effects of high-dose Cr supplementation on body fluid balance has not been fully investigated, and ingestion of Cr before or during exercise is not recommended. There is evidence that medical use of Cr supplementation is warranted in certain patients (e.g.. neuromuscular disease); future research may establish its potential usefulness in other medical applications. Although Cr supplementation exhibits small but significant physiological and performance changes, the increases in performance are realized during very specific exercise conditions. This suggests that the apparent high expectations for performance enhancement, evident by the extensive use of Cr supplementation, are inordinate.

A Randomized Prospective Trial to Assess the Role of Saline Hydration on the Development of Contrast Nephrotoxicity

Abstract: Though simple and attractive, the role of hydration for the prophylaxis of contrast nephrotoxicity has not been definitively established. We prospectively evaluated the role of deliberate saline hydra

A multisite study of the clinical diagnosis of different autism spectrum disorders

Abstract: Context Best-estimate clinical diagnoses of specific autism spectrum disorders (autistic disorder, pervasive developmental disorder–not otherwise specified, and Asperger syndrome) have been used as the diagnostic gold standard, even when information from standardized instruments is available. Objective To determine whether the relationships between behavioral phenotypes and clinical diagnoses of different autism spectrum disorders vary across 12 university-based sites. Design Multisite observational study collecting clinical phenotype data (diagnostic, developmental, and demographic) for genetic research. Classification trees were used to identify characteristics that predicted diagnosis across and within sites. Setting Participants were recruited through 12 university-based autism service providers into a genetic study of autism. Participants A total of 2102 probands (1814 male probands) between 4 and 18 years of age (mean [SD] age, 8.93 [3.5] years) who met autism spectrum criteria on the Autism Diagnostic Interview–Revised and the Autism Diagnostic Observation Schedule and who had a clinical diagnosis of an autism spectrum disorder. Main Outcome Measure Best-estimate clinical diagnoses predicted by standardized scores from diagnostic, cognitive, and behavioral measures. Results Although distributions of scores on standardized measures were similar across sites, significant site differences emerged in best-estimate clinical diagnoses of specific autism spectrum disorders. Relationships between clinical diagnoses and standardized scores, particularly verbal IQ, language level, and core diagnostic features, varied across sites in weighting of information and cutoffs. Conclusions Clinical distinctions among categorical diagnostic subtypes of autism spectrum disorders were not reliable even across sites with well-documented fidelity using standardized diagnostic instruments. Results support the move from existing subgroupings of autism spectrum disorders to dimensional descriptions of core features of social affect and fixated, repetitive behaviors, together with characteristics such as language level and cognitive function.

An Ultraviolet-to-Radio Broadband Spectral Atlas of Nearby Galaxies

Abstract: The ultraviolet-to-radio continuum spectral energy distributions are presented for all 75 galaxies in the Spitzer Infrared Nearby Galaxies Survey (SINGS). A principal component analysis of the sample shows that most of the sample's spectral variations stem from two underlying components, one representative of a galaxy with a low infrared-to-ultraviolet ratio and one representative of a galaxy with a high infrared-to-ultraviolet ratio. The influence of several parameters on the infrared-to-ultraviolet ratio is studied (e.g., optical morphology, disk inclination, far-infrared color, ultraviolet spectral slope, and star formation history). Consistent with our understanding of normal star-forming galaxies, the SINGS sample of galaxies in comparison to more actively star-forming galaxies exhibits a larger dispersion in the infrared-to-ultraviolet versus ultraviolet spectral slope correlation. Early-type galaxies, exhibiting low star formation rates and high optical surface brightnesses, have the most discrepant infrared-to-ultraviolet correlation. These results suggest that the star formation history may be the dominant regulator of the broadband spectral variations between galaxies. Finally, a new discovery shows that the 24 μm morphology can be a useful tool for parameterizing the global dust temperature and ultraviolet extinction in nearby galaxies. The dust emission in dwarf/irregular galaxies is clumpy and warm accompanied by low ultraviolet extinction, while in spiral galaxies there is typically a much larger diffuse component of cooler dust and average ultraviolet extinction. For galaxies with nuclear 24 μm emission, the dust temperature and ultraviolet extinction are relatively high compared to disk galaxies.