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Institution

University of Modena and Reggio Emilia

EducationModena, Italy
About: University of Modena and Reggio Emilia is a education organization based out in Modena, Italy. It is known for research contribution in the topics: Population & Medicine. The organization has 8179 authors who have published 22418 publications receiving 671337 citations. The organization is also known as: Università degli Studi di Modena e Reggio Emilia & Universita degli Studi di Modena e Reggio Emilia.


Papers
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Journal ArticleDOI
TL;DR: In this article, a distributed physically based model incorporating novel approaches for the representation of surface-subsurface processes and interactions is presented, with several options for identifying flow directions, for separating channel cells from hillslope cells, and for representing stream channel hydraulic geometry.
Abstract: Received 21 October 2008; revised 2 September 2009; accepted 16 September 2009; published 13 February 2010. [1] A distributed physically based model incorporating novel approaches for the representation of surface-subsurface processes and interactions is presented. A path-based description of surface flow across the drainage basin is used, with several options for identifying flow directions, for separating channel cells from hillslope cells, and for representing stream channel hydraulic geometry. Lakes and other topographic depressions are identified and specially treated as part of the preprocessing procedures applied to the digital elevation data for the catchment. Threshold-based boundary condition switching is used to partition potential (atmospheric) fluxes into actual fluxes across the land surface and changes in surface storage, thus resolving the exchange fluxes, or coupling, between the surface and subsurface modules. Nested time stepping allows smaller steps to be taken for typically faster and explicitly solved surface runoff routing, while a mesh coarsening option allows larger grid elements to be used for typically slower and more compute-intensive subsurface flow. Sequential data assimilation schemes allow the model predictions to be updated with spatiotemporal observation data of surface and subsurface variables. These approaches are discussed in detail, and the physical and numerical behavior of the model is illustrated over catchment scales ranging from 0.0027 to 356 km 2 , addressing different hydrological processes and highlighting the importance of describing coupled surfacesubsurface flow.

399 citations

Journal ArticleDOI
TL;DR: Most children and young adults with acquired central diabetes insipidus have abnormal findings on MRI scans of the head, which may change over time, and at least half have anterior pituitary hormone deficiencies during follow-up.
Abstract: Background Central diabetes insipidus is rare in children and young adults, and up to 50 percent of cases are idiopathic. The clinical presentation and the long-term course of this disorder are largely undefined. Methods We studied all 79 patients with central diabetes insipidus who were seen at four pediatric endocrinology units between 1970 and 1996. There were 37 male and 42 female patients whose median age at diagnosis was 7.0 years (range, 0.1 to 24.8). All patients underwent magnetic resonance imaging (MRI) and periodic studies of anterior pituitary function. The median duration of follow-up was 7.6 years (range, 1.6 to 26.2). Results The causes of the central diabetes insipidus were Langerhans'-cell histiocytosis in 12 patients, an intracranial tumor in 18 patients, a skull fracture in 2 patients, and autoimmune polyendocrinopathy in 1 patient; 5 patients had familial disease. The cause was considered to be idiopathic in 41 patients (52 percent). In 74 patients (94 percent) the posterior pituitary ...

394 citations

Journal ArticleDOI
TL;DR: New diagnostic models showed no significant improvement compared with the previously proposed confocal microscopy algorithm and seems useful for second level examination of clinically and dermoscopically equivocal lesions.

394 citations

Journal ArticleDOI
TL;DR: The possibility of founding a quantitative theory of aromaticity on the basis of measurable response properties is discussed in this paper, and the reasons suggesting that nonmeasurable parameters are unsuitable for quantitative evaluation of aromaticities are analyzed.
Abstract: The possibility of founding a quantitative theory of aromaticity on the basis of measurable response properties is discussed. The reasons suggesting that nonmeasurable parameters are unsuitable for quantitative evaluation of aromaticity are analyzed.

392 citations

Journal ArticleDOI
TL;DR: An overview of the 1,2,3-triazole ring as a bioisostere for the design of drug analogs, highlighting relevant recent examples.

392 citations


Authors

Showing all 8322 results

NameH-indexPapersCitations
Carlo M. Croce1981135189007
Gregory Y.H. Lip1693159171742
Geoffrey Burnstock141148899525
Peter M. Rothwell13477967382
Claudio Franceschi12085659868
Lorenzo Galluzzi11847771436
Leonardo M. Fabbri10956660838
David N. Reinhoudt107108248814
Stefano Pileri10063543369
Andrea Bizzeti99116846880
Brian K. Shoichet9828140313
Dante Gatteschi9772748729
Roberta Sessoli9542441458
Thomas A. Buchholz9349433409
Pier Luigi Zinzani9285735476
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202376
2022230
20212,354
20202,083
20191,633
20181,450