University of Modena and Reggio Emilia

About: University of Modena and Reggio Emilia is a education organization based out in Modena, Italy. It is known for research contribution in the topics: Population & Medicine. The organization has 8179 authors who have published 22418 publications receiving 671337 citations. The organization is also known as: Università degli Studi di Modena e Reggio Emilia & Universita degli Studi di Modena e Reggio Emilia.

Psychotropic drug utilization in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project.

Abstract: Objective: To assess psychotropic drug utilization in the general population of six European countries, and the pattern Of use in individuals with different DSM-IV diagnoses of 12-month mental disorders. Method: Data were derived from the European Study of the Epidemiology of Mental Disorders (ESEMeD/MHEDEA 2000), a cross-sectional psychiatric epidemiological study in a representative sample of 21 425 adults aged 18 or older from six European countries (e.g. Belgium. France, Germany, Italy.. the Netherlands and Spain). Individuals were asked about any psychotropic drug use in the past 12 months, even if they used the drug(s) just once. A colour booklet containing high-quality pictures of psychotropic drugs commonly used to treat mental disorders was provided to help respondents recall drug use. Results: Psychotropic drug utilization is generally low in individuals with any 12-month mental disorder (32.6%). The extent of psychotropic drug utilization varied according to the specific DSM-IV diagnosis. Among individuals with a 12-month diagnosis of pure major depression. only 21.2% had received any antidepressants within the same period; the exclusive use of antidepressants was even lower (4.6%), while more individuals took only anxiolytics (18.4%). Conclusion: These data question the appropriateness Of Current pharmacological treatments, particularly for major depression, in which under-treatment is coupled with the high use of non-specific medications, such as anxiolytics.

Definitions and outcome measures for bullous pemphigoid: Recommendations by an international panel of experts

Abstract: Our scientific knowledge of bullous pemphigoid (BP) has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have helped to define effective therapies in BP. A major obstacle in sharing multicenter-based evidences for therapeutic efforts is the lack of generally accepted definitions for the clinical evaluation of patients with BP. Common terms and end points of BP are needed so that experts in the field can accurately measure and assess disease extent, activity, severity, and therapeutic response, and thus facilitate and advance clinical trials. These recommendations from the International Pemphigoid Committee represent 2 years of collaborative efforts to attain mutually acceptable common definitions for BP and proposes a disease extent score, the BP Disease Area Index. These items should assist in the development of consistent reporting of outcomes in future BP reports and studies.

Folate production by bifidobacteria as a potential probiotic property.

Abstract: The ability of 76 Bifidobacterium strains to produce folate was investigated. In order to evaluate folic acid productivity, bifidobacteria were cultivated in the folate-free semisynthetic medium SM7. Most of the tested strains needed folate for growth. The production and the extent of vitamin accumulation were not a function of species but were distinctive features of individual strains. Six strains among the 17 that grew without folate produced significantly higher concentrations of vitamin (between 41 and 82 ng ml(-1)). The effects of exogenous folate and p-aminobenzoic acid (PABA) concentrations on folate production were evaluated. In contrast to most of the other strains, the folate yield of B. adolescentis MB 239 was not negatively affected by either PABA or exogenous folic acid. Folate production by B. adolescentis MB 239 was studied in the pH range of the colonic environment, and a comparison of folate production on raffinose, lactose, and fructo-oligosaccharides, which belong to three important groups of fermentable intestinal carbon sources, was established. Differences in folate biosynthesis by B. adolescentis MB 239 were not observed as a function either of the pH or of the carbon source. Fecal culture experiments demonstrated that the addition of B. adolescentis MB 239 may increase the folate concentration in the colonic environment.

The bike sharing rebalancing problem: Mathematical formulations and benchmark instances

Abstract: Bike sharing systems offer a mobility service whereby public bicycles, located at different stations across an urban area, are available for shared use. These systems contribute towards obtaining a more sustainable mobility and decreasing traffic and pollution caused by car transportation. Since the first bike sharing system was installed in Amsterdam in 1965, the number of such applications has increased remarkably so that hundreds of systems are now operating all over the world. In a bike sharing system, users can take a bicycle from a station, use it to perform a journey and then leave it at a station, not necessarily the same one of departure. This behavior typically leads to a situation in which some stations become full and others are empty. Hence, a balanced system requires the redistribution of bicycles among stations. In this paper, we address the Bike sharing Rebalancing Problem (BRP), in which a fleet of capacitated vehicles is employed in order to re-distribute the bikes with the objective of minimizing total cost. This can be viewed as a special one-commodity pickup-and-delivery capacitated vehicle routing problem. We present four mixed integer linear programming formulations of this problem. It is worth noting that the proposed formulations include an exponential number of constraints, hence, tailor-made branch-and-cut algorithms are developed in order to solve them. The mathematical formulations of the BRP were first computationally tested using data obtained for the city of Reggio Emilia, Italy. Our computational study was then extended to include bike sharing systems from other parts of the world. The information derived from the study was used to build a set of benchmark instances for the BRP which we made publicly available on the web. Extensive experimentation of the branch-and-cut algorithms presented in this paper was carried out and an interesting computational comparison of the proposed mathematical formulations is reported. Finally, several insights on the computational difficulty of the problem are highlighted.