Institution
University of Modena and Reggio Emilia
Education•Modena, Italy•
About: University of Modena and Reggio Emilia is a education organization based out in Modena, Italy. It is known for research contribution in the topics: Population & Medicine. The organization has 8179 authors who have published 22418 publications receiving 671337 citations. The organization is also known as: Università degli Studi di Modena e Reggio Emilia & Universita degli Studi di Modena e Reggio Emilia.
Topics: Population, Medicine, Cancer, Context (language use), Computer science
Papers published on a yearly basis
Papers
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TL;DR: A new physiological noise model (PNM) based on retrospective image correction (RETROICOR), which uses independent physiological measurements taken from the subject to model sources of noise, was defined and improved obtained when using a PNM in estimating spinal cord activation.
222 citations
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TL;DR: In this paper, the capabilities of L-band satellite SAR interferometry for the investigation of landslide displacements have been analyzed together with C-band ERS-1/2 SAR data and in situ information.
Abstract: This paper illustrates the capabilities of L-band satellite SAR interferometry for the investigation of landslide displacements. SAR data acquired by the L-band JERS satellite over the Italian and Swiss Alps have been analyzed together with C-band ERS-1/2 SAR data and in situ information. The use of L-band SAR data with a wavelength larger than the usual C-band, generally considered for ground motion measurements, reduces some of the limitations of differential SAR interferometry, in particular, signal decorrelation induced by vegetation cover and rapid displacements. The sites of the Alta Val Badia region in South Tyrol (Italy), Ruinon in Lombardia (Italy), Saas Grund in Valais (Switzerland) and Campo Vallemaggia in Ticino (Switzerland), representing a comprehensive set of different mass wasting phenomena in various environments, are considered. The landslides in the Alta Val Badia region are good examples for presenting the improved performance of L-band in comparison to C-band for vegetated areas, in particular concerning open forest. The landslides of Ruinon, Saas Grund, and Campo Vallemaggia demonstrate the strength of L-band in observing moderately fast displacements in comparison to C-band. This work, performed with historical SAR data from a satellite which operated until 1998, demonstrates the capabilities of future planned L-band SAR missions, like ALOS and TerraSAR-L, for landslide studies.
221 citations
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TL;DR: It has now become possible to show that A2A and D2 receptors also coimmunoprecipitate in striatal tissue, giving evidence for the existence of A 2A-D2 heteromeric receptor complexes also in ratstriatal tissue and giving evidence that these heteromers are constitutive.
Abstract: The existence of A2A-D2 heteromeric complexes is based on coimmunoprecipitation studies and on fluorescence resonance energy transfer and bioluminescence resonance energy transfer analyses. It has now become possible to show that A2A and D2 receptors also coimmunoprecipitate in striatal tissue, giving evidence for the existence of A2A-D2 heteromeric receptor complexes also in rat striatal tissue. The analysis gives evidence that these heteromers are constitutive, as they are observed in the absence of A2A and D2 agonists. The A2A-D2 heteromers could either be A2A-D2 heterodimers and/or higher-order A2A -D2 hetero-oligomers. In striatal neurons there are probably A2A-D2 heteromeric complexes, together with A2A-D2 homomeric complexes in the neuronal surface membrane. Their stoichiometry in various microdomains will have a major role in determining A2A and D2 signaling in the striatopallidal GABA neurons. Through the use of D2/D1 chimeras, evidence has been obtained that the fifth transmembrane (TM) domain and/or the I3 of the D2 receptor are part of the A2A-D2 receptor interface, where electrostatic epitope-epitope interactions involving the N-terminal part of I3 of the D2 receptor (arginine-rich epitope) play a major role, interacting with the carboxyl terminus of the A2A receptor. Computerized modeling of A2A-D2 heteromers are in line with these findings. It seems likely that A2A receptor-induced reduction of D2 receptor recognition, G protein coupling, and signaling, as well as the existence of A2A-D2 co-trafficking, are the consequence of the existence of an A2A-D2 receptor heteromer. The relevance of A2A-D2 heteromeric receptor complexes for Parkinson's disease and schizophrenia is emphasized as well as for the treatment of these diseases. Finally, recent evidence for the existence of antagonistic A2A-D3 heteromeric receptor complexes in cotransfected cell lines has been summarized.
221 citations
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TL;DR: Baseline TMTV is a strong independent predictor of outcome in FL and warrants further validation as a biomarker for development of first-line PET-adapted approaches in FL.
Abstract: PurposeIdentifying patients at high risk of progression and early death among those with high-tumor-burden follicular lymphoma (FL) is unsatisfactory with current prognostic models. This study aimed to determine the prognostic impact of the total metabolic tumor volume (TMTV) measured at baseline with [18F]fluorodeoxyglucose/positron emission tomography-computed tomography ([18F]FDG/PET-CT) scans and its added value to these models.Patients and MethodsA pooled analysis was performed by using patient data and centrally reviewed baseline PET-CT scans for 185 patients with FL who were receiving immunochemotherapy within three prospective trials. TMTV was computed by using the 41% maximum standardized uptake value thresholding method, and the optimal cutoff for survival prediction was determined.ResultsMedian age was 55 years, 92% of patients had stage III to IV disease, 37% had a Follicular Lymphoma International Prognostic Index (FLIPI) score of 3 to 5, and 31% had a FLIPI2 score of 3 to 5. With a median fo...
221 citations
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TL;DR: The most difficult scientific challenge for this future vaccine obtained in the laboratory is the proof of clinical safety and efficacy of the COVID-19 vaccine.
Abstract: In the current context of the pandemic triggered by SARS-COV-2, the immunization of the population through vaccination is recognized as a public health priority. In the case of SARS‑COV‑2, the genetic sequencing was done quickly, in one month. Since then, worldwide research has focused on obtaining a vaccine. This has a major economic impact because new technological platforms and advanced genetic engineering procedures are required to obtain a COVID‑19 vaccine. The most difficult scientific challenge for this future vaccine obtained in the laboratory is the proof of clinical safety and efficacy. The biggest challenge of manufacturing is the construction and validation of production platforms capable of making the vaccine on a large scale.
220 citations
Authors
Showing all 8322 results
Name | H-index | Papers | Citations |
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Carlo M. Croce | 198 | 1135 | 189007 |
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Geoffrey Burnstock | 141 | 1488 | 99525 |
Peter M. Rothwell | 134 | 779 | 67382 |
Claudio Franceschi | 120 | 856 | 59868 |
Lorenzo Galluzzi | 118 | 477 | 71436 |
Leonardo M. Fabbri | 109 | 566 | 60838 |
David N. Reinhoudt | 107 | 1082 | 48814 |
Stefano Pileri | 100 | 635 | 43369 |
Andrea Bizzeti | 99 | 1168 | 46880 |
Brian K. Shoichet | 98 | 281 | 40313 |
Dante Gatteschi | 97 | 727 | 48729 |
Roberta Sessoli | 95 | 424 | 41458 |
Thomas A. Buchholz | 93 | 494 | 33409 |
Pier Luigi Zinzani | 92 | 857 | 35476 |