University of Mons

About: University of Mons is a education organization based out in Mons, Belgium. It is known for research contribution in the topics: Large Hadron Collider & Standard Model. The organization has 3073 authors who have published 9465 publications receiving 294776 citations.

Super-resolution microscopy reveals LINC complex recruitment at nuclear indentation sites

Abstract: Increasing evidences show that the actin cytoskeleton is a key parameter of the nuclear remodeling process in response to the modifications of cellular morphology. However, detailed information on the interaction between the actin cytoskeleton and the nuclear lamina was still lacking. We addressed this question by constraining endothelial cells on rectangular fibronectin-coated micropatterns and then using Structured Illumination Microscopy (SIM) to observe the interactions between actin stress fibers, nuclear lamina and LINC complexes at a super-resolution scale. Our results show that tension in apical actin stress fibers leads to deep nuclear indentations that significantly deform the nuclear lamina. Interestingly, indented nuclear zones are characterized by a local enrichment of LINC complexes, which anchor apical actin fibers to the nuclear lamina. Moreover, our findings indicate that nuclear indentations induce the formation of segregated domains of condensed chromatin. However, nuclear indentations and condensed chromatin domains are not irreversible processes and both can relax in absence of tension in apical actin stress fibers.

Cerebellar hypermetria is larger when the inertial load is artificially increased

Abstract: Hypermetria is a classical cerebellar symptom designating the overshoot observed when a patient is asked to make a very fast and accurate movement. The movement studied here was wrist flexion. Hypermetria was found to be increased by artificially increasing the inertia of the moving hand. A normal subject adapted himself to increasing inertia by increasing both his agonist activity (the launching force) and its antagonist activity (the braking force). In the same circumstances, a patient with symptoms of cerebellar system dysfunction was found to be able to increase his agonist activity but not his antagonist activity.

Applying a Model Transformation Taxonomy to Graph Transformation Technology

Abstract: A taxonomy of model transformations was introduced in [T. Mens, P.V. Gorp, A taxonomy of model transformation, in: Proc. Int'l Workshop on Graph and Model Transformation (GraMoT 2005), Electronic Notes in Computer Science (2005)]. Among others, such a taxonomy can help developers in deciding which language, forma lism, tool or mechanism is best suited to carry out a particular model transformation activity. In this paper we apply the taxonomy to the technique of graph transformation, and we exemplify it by referring to four representative graph transformation tools. As a byproduct of our analysis, we discuss how well each of the considered tools carry out the activity of model transformation.

Photo-modulable molecular transport junctions based on organometallic molecular wires

Abstract: Photo-modulable molecular transport junctions are developed via on-wire lithography-fabricated nanogaps functionalized with a dithienylethene unit bearing two ruthenium fragments. A reversible and repeatable bi-state conductive switching upon alternate irradiation of UV and visible light can be distinctly observed. Theoretical calculations further suggest that bi-directional isomerization is due to the ruthenium moieties that modulate judiciously the electronic coupling between the photochromic part and the metal electrodes, and that the differences in electronic structure between the two isomers (open and closed states) are responsible for conductivity switching.