Institution
University of Mons
Education•Mons, Belgium•
About: University of Mons is a education organization based out in Mons, Belgium. It is known for research contribution in the topics: Large Hadron Collider & Standard Model. The organization has 3073 authors who have published 9465 publications receiving 294776 citations.
Topics: Large Hadron Collider, Standard Model, Lepton, Fiber Bragg grating, Muon
Papers published on a yearly basis
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TL;DR: It is demonstrated that TCR-induced nuclear export of HDAC7 and Nur77 expression is mediated by activation of protein kinase D (PKD), which indicates that PKD is likely to play a key role in the signaling pathways controlling negative selection.
Abstract: The molecular basis of thymocyte negative selection, a crucial mechanism in establishing central tolerance, is not yet resolved. Histone deacetylases (HDACs) have emerged as key transcriptional regulators in several major developmental programs. Recently, we showed that the class IIa member, HDAC7, regulates negative selection by repressing expression of Nur77, an orphan nuclear receptor involved in antigen-induced apoptosis of thymocytes. Engagement of the T cell receptor (TCR) alleviates this repression through phosphorylation-dependent nuclear exclusion of HDAC7. However, the identity of the TCR-activated kinase that phosphorylates and inactivates HDAC7 was still unknown. Here, we demonstrate that TCR-induced nuclear export of HDAC7 and Nur77 expression is mediated by activation of protein kinase D (PKD). Indeed, active PKD stimulates HDAC7 nuclear export and Nur77 expression. In contrast, inhibition of PKD prevents TCR-mediated nuclear exclusion of HDAC7 and associated Nur77 activation. Furthermore, we show that HDAC7 is an interaction partner and a substrate for PKD. We identify four serine residues in the NH2 terminus of HDAC7 as targets for PKD. More importantly, a mutant of HDAC7 specifically deficient in phosphorylation by PKD, inhibits TCR-mediated apoptosis of T cell hybridomas. These findings indicate that PKD is likely to play a key role in the signaling pathways controlling negative selection.
172 citations
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TL;DR: Patients at risk are mainly those with previous experience of hepatotoxic reaction to antibiotics, the aged or those with impaired hepatic function in the absence of close monitoring, making it important to carefully balance potential risks with expected benefits in primary care.
Abstract: Antibiotics used by general practitioners frequently appear in adverse-event reports of drug-induced hepatotoxicity. Most cases are idiosyncratic (the adverse reaction cannot be predicted from the drug's pharmacological profile or from pre-clinical toxicology tests) and occur via an immunological reaction or in response to the presence of hepatotoxic metabolites. With the exception of trovafloxacin and telithromycin (now severely restricted), hepatotoxicity crude incidence remains globally low but variable. Thus, amoxicillin/clavulanate and co-trimoxazole, as well as flucloxacillin, cause hepatotoxic reactions at rates that make them visible in general practice (cases are often isolated, may have a delayed onset, sometimes appear only after cessation of therapy and can produce an array of hepatic lesions that mirror hepatobiliary disease, making causality often difficult to establish). Conversely, hepatotoxic reactions related to macrolides, tetracyclines and fluoroquinolones (in that order, from high to low) are much rarer, and are identifiable only through large-scale studies or worldwide pharmacovigilance reporting. For antibiotics specifically used for tuberculosis, adverse effects range from asymptomatic increases in liver enzymes to acute hepatitis and fulminant hepatic failure. Yet, it is difficult to single out individual drugs, as treatment always entails associations. Patients at risk are mainly those with previous experience of hepatotoxic reaction to antibiotics, the aged or those with impaired hepatic function in the absence of close monitoring, making it important to carefully balance potential risks with expected benefits in primary care. Pharmacogenetic testing using the new genome-wide association studies approach holds promise for better understanding the mechanism(s) underlying hepatotoxicity.
172 citations
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TL;DR: Each component of the early SEPs was thus distinctly influenced by the gating process during active movement interference, which could be in favour of separate cortical generators in the debate on the origin of SEP components.
172 citations
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TL;DR: The modification of conventional toxicity assays and the consideration of the “cell vision” concept are crucial matters to obtain reliable, and reproducible nanotoxicology data and offer a suitable way to obtain a deep understanding on the cell-NP interactions.
Abstract: Until now, the results of nanotoxicology research have shown that the interactions between nanoparticles (NPs) and cells are remarkably complex. In order to get a deep understanding of the NP-cell interactions, scientists have focused on the physicochemical effects. However, there are still considerable debates about the regulation of nanomaterials and the reported results are usually in contradictions. Here, we are going to introduce the potential key reasons for these conflicts. In this case, modification of conventional in vitro toxicity assays, is one of the crucial ignored matter in nanotoxicological sciences. More specifically, the conventional methods neglect important factors such as the sedimentation of NPs and absorption of proteins and other essential biomolecules onto the surface of NPs. Another ignored matter in nanotoxicological sciences is the effect of cell “vision” (i.e., cell type). In order to show the effects of these ignored subjects, we probed the effect of superparamagnetic iron oxide NPs (SPIONs), with various surface chemistries, on various cell lines. We found thatthe modification of conventional toxicity assays and the consideration of the “cell vision” concept are crucial matters to obtain reliable, and reproducible nanotoxicology data. These new concepts offer a suitable way to obtain a deep understanding on the cell-NP interactions. In addition, by consideration of these ignored factors, the conflict of future toxicological reports would be significantly decreased.
171 citations
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TL;DR: A review of metal-free catalysts for cyclic carbonate polycarbonates can be found in this paper, where the authors provide a complete account of the various metal free catalysts that have been developed so far as well as comprehensive investigations on the related polymerization mechanisms.
171 citations
Authors
Showing all 3115 results
Name | H-index | Papers | Citations |
---|---|---|---|
Giacomo Bruno | 158 | 1687 | 124368 |
Krzysztof Piotrzkowski | 141 | 1269 | 99607 |
Maria Elena Pol | 139 | 1414 | 99240 |
Rupert Leitner | 136 | 1201 | 90597 |
Christophe Delaere | 135 | 1320 | 96742 |
Vincent Lemaitre | 134 | 1310 | 99190 |
Jean-Luc Brédas | 134 | 1026 | 85803 |
Luiz Mundim | 133 | 1413 | 89792 |
Ulrich Landgraf | 131 | 959 | 83320 |
Markus Elsing | 131 | 1111 | 82757 |
Evangelos Gazis | 131 | 1147 | 84159 |
Loic Quertenmont | 129 | 905 | 76221 |
Michele Selvaggi | 129 | 1214 | 83525 |
Roberto Castello | 128 | 965 | 76820 |
Olivier Bondu | 128 | 1049 | 76124 |