Showing papers by "University of Montpellier published in 2004"

APE: Analyses of Phylogenetics and Evolution in R language

Abstract: Summary: Analysis of Phylogenetics and Evolution (APE) is a package written in the R language for use in molecular evolution and phylogenetics. APE provides both utility functions for reading and writing data and manipulating phylogenetic trees, as well as several advanced methods for phylogenetic and evolutionary analysis (e.g. comparative and population genetic methods). APE takes advantage of the many R functions for statistics and graphics, and also provides a flexible framework for developing and implementing further statistical methods for the analysis of evolutionary processes. Availability: The program is free and available from the official R package archive at http://cran.r-project.org/src/contrib/PACKAGES.html#ape. APE is licensed under the GNU General Public License.

The metacommunity concept: a framework for multi-scale community ecology

Abstract: The metacommunity concept is an important way to think about linkages between different spatial scales in ecology. Here we review current understanding about this concept. We first investigate issues related to its definition as a set of local communities that are linked by dispersal of multiple potentially interacting species. We then identify four paradigms for metacommunities: the patch-dynamic view, the species-sorting view, the mass effects view and the neutral view, that each emphasizes different processes of potential importance in metacommunities. These have somewhat distinct intellectual histories and we discuss elements related to their potential future synthesis. We then use this framework to discuss why the concept is useful in modifying existing ecological thinking and illustrate this with a number of both theoretical and empirical examples. As ecologists strive to understand increasingly complex mechanisms and strive to work across multiple scales of spatio-temporal organization, concepts like the metacommunity can provide important insights that frequently contrast with those that would be obtained with more conventional approaches based on local communities alone.

First stars V - abundance patterns from C to Zn and supernova yields in the early galaxy

Abstract: In the framework of the ESO Large Programme "First Stars", very high-quality spectra of some 70 very metal-poor dwarfs and giants were obtained with the ESO VLT and UVES spectrograph. These stars are likely to have descended from the first generation(s) of stars formed after the Big Bang, and their detailed composition provides constraints on issues such as the nature of the first supernovae, the efficiency of mixing processes in the early Galaxy, the formation and evolution of the halo of the Galaxy, and the possible sources of reionization of the Universe. This paper presents the abundance analysis of an homogeneous sample of 35 giants selected from the HK survey of Beers et al. (1992, 1999), emphasizing stars of extremely low metallicity: 30 of our 35 stars are in the range −4.1 < (Fe/H) < −2. 7, and 22 stars have (Fe/H) < −3.0. Our new VLT/UVES spectra, at a resolving power of R ∼ 45 000 and with signal-to-noise ratios of 100-200 per pixel over the wavelength range 330-1000 nm, are greatly superior to those of the classic studies of McWilliam et al. (1995) and Ryan et al. (1996). The immediate objective of the work is to determine precise, comprehensive, and homogeneous element abundances for this large sample of the most metal-poor giants presently known. In the analysis we combine the spectral line modeling code "Turbospectrum" with OSMARCS model atmospheres, which treat continuum scattering correctly and thus allow proper inter- pretation of the blue regions of the spectra, where scattering becomes important relative to continuous absorption ( λ< 400 nm). We obtain detailed information on the trends of elemental abundance ratios and the star-to-star scatter around those trends, en- abling us to separate the relative contributions of cosmic scatter and observational/analysis errors. Abundances of 17 elements from C to Zn have been measured in all stars, including K and Zn, which have not previously been detected in stars with (Fe/H) < −3.0. Among the key results, we discuss the oxygen abundance (from the forbidden (OI) line), the different and sometimes complex trends of the abundance ratios with metallicity, the very tight relationship between the abundances of certain elements (e.g., Fe and Cr), and the high (Zn/Fe) ratio in the most metal-poor stars. Within the error bars, the trends of the abundance ratios with metallicity are consistent with those found in earlier literature, but in many cases the scatter around the average trends is much smaller than found in earlier studies, which were limited to lower-quality spectra. We find that the cosmic scatter in several element ratios may be as low as 0.05 dex. The evolution of the abundance trends and scatter with declining metallicity provides strong constraints on the yields of the first supernovae and their mixing into the early ISM. The abundance ratios found in our sample do not match the predicted yields from pair-instability hypernovae, but are consistent with element production by super- novae with progenitor masses up to 100 M� . Moreover, the composition of the ejecta that have enriched the matter

IMGT®, the international ImMunoGeneTics information system®

Abstract: The international ImMunoGeneTics information system® (IMGT) (http://imgt.cines.fr), created in 1989, by the Laboratoire d'ImmunoGenetique Moleculaire LIGM (Universite Montpellier II and CNRS) at Montpellier, France, is a high-quality integrated knowledge resource specializing in the immunoglobulins (IGs), T cell receptors (TRs), major histocompatibility complex (MHC) of human and other vertebrates, and related proteins of the immune systems (RPI) that belong to the immunoglobulin superfamily (IgSF) and to the MHC superfamily (MhcSF). IMGT includes several sequence databases (IMGT/LIGM-DB, IMGT/PRIMER-DB, IMGT/PROTEIN-DB and IMGT/MHC-DB), one genome database (IMGT/GENE-DB) and one three-dimensional (3D) structure database (IMGT/3Dstructure-DB), Web resources comprising 8000 HTML pages (IMGT Marie-Paule page), and interactive tools. IMGT data are expertly annotated according to the rules of the IMGT Scientific chart, based on the IMGT-ONTOLOGY concepts. IMGT tools are particularly useful for the analysis of the IG and TR repertoires in normal physiological and pathological situations. IMGT is used in medical research (autoimmune diseases, infectious diseases, AIDS, leukemias, lymphomas, myelomas), veterinary research, biotechnology related to antibody engineering (phage displays, combinatorial libraries, chimeric, humanized and human antibodies), diagnostics (clonalities, detection and follow up of residual diseases) and therapeutical approaches (graft, immunotherapy and vaccinology). IMGT is freely available at http://imgt.cines.fr.

Present‐day crustal deformation and plate kinematics in the Middle East constrained by GPS measurements in Iran and northern Oman

Abstract: SUMMARY A network of 27 GPS sites was implemented in Iran and northern Oman to measure displacements in this part of the Alpine‐Himalayan mountain belt. We present and interpret the results of two surveys performed in 1999 September and 2001 October. GPS sites in Oman show northward motion of the Arabian Plate relative to Eurasia slower than the NUVEL-1A estimates (e.g. 22 ± 2m m yr −1 at N8 ◦ ± 5 ◦ E instead of 30.5 mm yr −1 at N6 ◦ E at Bahrain longitude). We define a GPS Arabia‐Eurasia Euler vector of 27.9 ◦ ± 0.5 ◦ N, 19.5 ◦ ± 1.4 ◦ E, 0.41 ◦ ± 0.1 ◦ Myr −1 . The Arabia‐Eurasia convergence is accommodated differently in eastern and western Iran. East of 58 ◦ E, most of the shortening is accommodated by the Makran subduction zone (19.5 ± 2m m yr −1 ) and less by the Kopet-Dag (6.5 ± 2m m yr −1 ). West of 58 ◦ E, the deformation is distributed in separate fold and thrust belts. At the longitude of Tehran, the Zagros and the Alborz mountain ranges accommodate 6.5 ± 2m m yr −1 and 8 ± 2m m yr −1 respectively. The right-lateral displacement along the Main Recent Fault in the northern Zagros is about 3 ± 2m m yr −1 , smaller than what was generally expected. By contrast, large rightlateral displacement takes place in northwestern Iran (up to 8 ± mm yr −1 ). The Central Iranian Block is characterized by coherent plate motion (internal deformation < 2m m yr −1 ). Sites east of 61 ◦ E show very low displacements relative to Eurasia. The kinematic contrast between eastern and western Iran is accommodated by strike-slip motions along the Lut Block. To the south, the transition zone between Zagros and Makran is under transpression with right-lateral displacements of 11 ± 2m m yr −1 .

SUSY Les Houches accord: interfacing SUSY spectrum calculators, decay packages, and event generators

Abstract: An accord specifying a unique set of conventions for supersymmetric extensions of the Standard Model together with generic file structures for 1) supersymmetric model specifications and input parameters, 2) electroweak scale supersymmetric mass and coupling spectra, and 3) decay tables is presented, to provide a universal interface between spectrum calculation programs, decay packages, and high energy physics event generators.

Ecology drives the worldwide distribution of human diseases.

Abstract: Identifying the factors underlying the origin and maintenance of the latitudinal diversity gradient is a central problem in ecology, but no consensus has emerged on which processes might generate this broad pattern. Interestingly, the vast majority of studies exploring the gradient have focused on free-living organisms, ignoring parasitic and infectious disease (PID) species. Here, we address the influence of environmental factors on the biological diversity of human pathogens and their global spatial organization. Using generalized linear multivariate models and Monte Carlo simulations, we conducted a series of comparative analyses to test the hypothesis that human PIDs exhibit the same global patterns of distribution as other taxonomic groups. We found a significant negative relationship between latitude and PID species richness, and a nested spatial organization, i.e., the accumulation of PID species with latitude, over large spatial scales. Additionally, our results show that climatic factors are of primary importance in explaining the link between latitude and the spatial pattern of human pathogens. Based on our findings, we propose that the global latitudinal species diversity gradient might be generated in large part by biotic interactions, providing strong support for the idea that current estimates of species diversity are substantially underestimated. When parasites and pathogens are included, estimates of total species diversity may increase by more than an order of magnitude.

High-energy particle acceleration in the shell of a supernova remnant.

Abstract: A significant fraction of the energy density of the interstellar medium is in the form of high-energy charged particles (cosmic rays)1. The origin of these particles remains uncertain. Although it is generally accepted that the only sources capable of supplying the energy required to accelerate the bulk of Galactic cosmic rays are supernova explosions, and even though the mechanism of particle acceleration in expanding supernova remnant (SNR) shocks is thought to be well understood theoretically2,3, unequivocal evidence for the production of high-energy particles in supernova shells has proven remarkably hard to find. Here we report on observations of the SNR RX J1713.7 - 3946 (G347.3 - 0.5), which was discovered by ROSAT4 in the X-ray spectrum and later claimed as a source of high-energy γ-rays5,6 of TeV energies (1 TeV = 1012 eV). We present a TeV γ-ray image of the SNR: the spatially resolved remnant has a shell morphology similar to that seen in X-rays, which demonstrates that very-high-energy particles are accelerated there. The energy spectrum indicates efficient acceleration of charged particles to energies beyond 100 TeV, consistent with current ideas of particle acceleration in young SNR shocks.

IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes

Abstract: IMGT/GENE-DB is the comprehensive IMGT genome database for immunoglobulin (IG) and T cell receptor (TR) genes from human and mouse, and, in development, from other vertebrates. IMGT/GENE-DB is the international reference for the IG and TR gene nomenclature and works in close collaboration with the HUGO Nomenclature Committee, Mouse Genome Database and genome committees for other species. IMGT/GENE-DB allows a search of IG and TR genes by locus, group and subgroup, which are CLASSIFICATION concepts of IMGT-ONTOLOGY. Short cuts allow the retrieval gene information by gene name or clone name. Direct links with configurable URL give access to information usable by humans or programs. An IMGT/GENE-DB entry displays accurate gene data related to genome (gene localization), allelic polymorphisms (number of alleles, IMGT reference sequences, functionality, etc.) gene expression (known cDNAs), proteins and structures (Protein displays, IMGT Colliers de Perles). It provides internal links to the IMGT sequence databases and to the IMGT Repertoire Web resources, and external links to genome and generalist sequence databases. IMGT/GENE-DB manages the IMGT reference directory used by the IMGT tools for IG and TR gene and allele comparison and assignment, and by the IMGT databases for gene data annotation. IMGT/GENE-DB is freely available at http://imgt.cines.fr.

The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vectors.

Abstract: High insecticide resistance resulting from insensitive acetylcholinesterase (AChE) has emerged in mosquitoes. A single mutation (G119S of the ace-1 gene) explains this high resistance in Culex pipiens and in Anopheles gambiae. In order to provide better documentation of the ace-1 gene and the effect of the G119S mutation, we present a three-dimension structure model of AChE, showing that this unique substitution is localized in the oxyanion hole, explaining the insecticide insensitivity and its interference with the enzyme catalytic functions. As the G119S creates a restriction site, a simple PCR test was devised to detect its presence in both A. gambiae and C. pipiens, two mosquito species belonging to different subfamilies (Culicinae and Anophelinae). It is possibile that this mutation also explains the high resistance found in other mosquitoes, and the present results indicate that the PCR test detects the G119S mutation in the malaria vector A. albimanus. The G119S has thus occurred independently at least four times in mosquitoes and this PCR test is probably of broad applicability within the Culicidae family.

Insights into the anti-microbial defense of marine invertebrates: the penaeid shrimps and the oyster Crassostrea gigas

Abstract: Research on innate immunity of the penaeid shrimps and the oyster Crassostrea gigas is motivated greatly by economical necessities. Indeed, the aquaculture of these organisms is now limited by the development of infectious diseases. Studying anti-microbial peptides/proteins (AMPs), which are effector molecules of the host defense, is particularly attractive not only for progressing basic knowledge on immunity but also because they offer various possible applications for disease management in aquaculture. AMPs are explored with a global approach,considering their structure, properties, function, gene expression, and tissue distribution during the response to infections. In shrimp, investigations of the penaeidins, which are constitutively expressed peptides, have highlighted the importance of hemocytes and hematopoiesis as major elements of the immune response, providing both local and systemic reactions. The activation of hematopoiesis must be regarded as a regulatory way for the expression and distribution of constitutively expressed immune effectors. As complementary approaches, genomics and gene profiling are promising to deepen our understanding of the anti-microbial defense of the oyster and the shrimp. However, real progress will depend also on the characterization of hemocyte lineages and hematopoiesis of these marine invertebrates as well as on the ontogenesis of their immune systems.

Prevalence and Seasonal Variations of Six Bee Viruses in Apis mellifera L. and Varroa destructor Mite Populations in France

Abstract: A survey of six bee viruses on a large geographic scale was undertaken by using seemingly healthy bee colonies and the PCR technique. Samples of adult bees and pupae were collected from 36 apiaries in the spring, summer, and autumn during 2002. Varroa destructor samples were collected at the end of summer following acaricide treatment. In adult bees, during the year deformed wing virus (DWV) was found at least once in 97% of the apiaries, sacbrood virus (SBV) was found in 86% of the apiaries, chronic bee paralysis virus (CBPV) was found in 28% of the apiaries, acute bee paralysis virus (ABPV) was found in 58% of the apiaries, black queen cell virus (BQCV) was found in 86% of the apiaries, and Kashmir bee virus (KBV) was found in 17% of the apiaries. For pupae, the following frequencies were obtained: DWV, 94% of the apiaries; SBV, 80% of the apiaries; CBPV, none of the apiaries; ABPV, 23% of the apiaries; BQCV, 23% of the apiaries; and KBV, 6% of the apiaries. In Varroa samples, the following four viruses were identified: DWV (100% of the apiaries), SBV (45% of the apiaries), ABPV (36% of the apiaries), and KBV (5% of the apiaries). The latter findings support the putative role of mites in transmitting these viruses. Taken together, these data indicate that bee virus infections occur persistently in bee populations despite the lack of clinical signs, suggesting that colony disease outbreaks might result from environmental factors that lead to activation of viral replication in bees.

Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation

Abstract: Imprinted genes are expressed from only one of the parental chromosomes and are marked epigenetically by DNA methylation and histone modifications1,2,3,4,5,6,7,8,9. The imprinting center 2 (IC2) on mouse distal chromosome 7 is flanked by several paternally repressed genes, with the more distant ones imprinted exclusively in the placenta. We found that most of these genes lack parent-specific DNA methylation, and genetic ablation of methylation does not lead to loss of their imprinting in the trophoblast (placenta). The silent paternal alleles of the genes are marked in the trophoblast by repressive histone modifications (dimethylation at Lys9 of histone H3 and trimethylation at Lys27 of histone H3), which are disrupted when IC2 is deleted, leading to reactivation of the paternal alleles. Thus, repressive histone methylation is recruited by IC2 (potentially through a noncoding antisense RNA) to the paternal chromosome in a region of at least 700 kb and maintains imprinting in this cluster in the placenta, independently of DNA methylation. We propose that an evolutionarily older imprinting mechanism limited to extraembryonic tissues was based on histone modifications, and that this mechanism was subsequently made more stable for use in embryonic lineages by the recruitment of DNA methylation.

Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes.

Abstract: Imprinted genes are clustered in domains, and their allelic repression is mediated by imprinting control regions1,2,3. These imprinting control regions are marked by DNA methylation, which is essential to maintain imprinting in the embryo4. To explore how imprinting is regulated in placenta, we studied the Kcnq1 domain on mouse distal chromosome 7. This large domain is controlled by an intronic imprinting control region5,6 and comprises multiple genes that are imprinted in placenta, without the involvement of promoter DNA methylation7,8,9,10. We found that the paternal repression along the domain involves acquisition of trimethylation at Lys27 and dimethylation at Lys9 of histone H3. Eed-Ezh2 Polycomb complexes are recruited to the paternal chromosome and potentially regulate its repressive histone methylation. Studies on embryonic stem cells and early embryos support our proposal that chromatin repression is established early in development and is maintained in the placenta. In the embryo, however, imprinting is stably maintained only at genes that have promoter DNA methylation. These data underscore the importance of histone methylation in placental imprinting and identify mechanistic similarities with X-chromosome inactivation in extraembryonic tissues, suggesting that the two epigenetic mechanisms are evolutionarily linked.

Managing the Complexity of Human/Machine Interactions in Computerized Learning Environments: Guiding Students’ Command Process through Instrumental Orchestrations

Abstract: After an introduction which addresses some basic questions, this article is organized around three points: (1) The theoretical framework of the so-called “instrumental approach” which has been a theme in the last two CAME symposia; (2) A consideration of two processes (instrumentalization and instrumentation) which interact in the instrumental genesis; and (3) The introduction of the idea of instrumental orchestration as a way of allowing the teacher to assist the student’s instrumental genesis.

Electrical stimulation of the globus pallidus internus in patients with primary generalized dystonia: long-term results

Abstract: Object. Primary generalized dystonia (PGD) is a medically refractory disease of the brain causing twisting or spasmodic movements and abnormal postures. In more than 30% of cases it is associated with the autosomal DYT1 mutation. Continuous electrical stimulation of the globus pallidus internus (GPi) has been used successfully in the treatment of PGD. The aim of this study was to examine the long-term efficacy and safety of deep brain stimulation (DBS) in the treatment of PGD in children and adults with and without the DYT1 mutation. Methods. Thirty-one patients with PGD were selected for surgery. Electrodes were bilaterally implanted under stereotactic guidance and connected to neurostimulators that were inserted subcutaneously. Efficacy was evaluated by comparing scores on the clinical and functional Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) before and after implantation. The efficacy of stimulation improved with time. After 2 years, compared with preoperative values, the mean (� standard deviation) clinical and functional BFMDRS scores had improved by 79 � 19% and 65 � 33%, respectively. At the 2-year follow-up examination the improvement was comparable in patients with and without the DYT1 mutation in both the functional (p = 0.12) and clinical (p = 0.33) scores. Children displayed greater improvements in the clinical score than adult patients (p = 0.04) at 2 years of follow up. In contrast, there was no significant difference in functional scores between children and adults (p = 0.95). Conclusions. Electrical stimulation of the GPi is an effective, reversible, and adaptable treatment for PGD and should be considered for conditions refractory to pharmaceutical therapies.

Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin

Abstract: Ezrin, a membrane–actin cytoskeleton linker, which participates in epithelial cell morphogenesis, is held inactive in the cytoplasm through an intramolecular interaction. Phosphatidylinositol 4,5-bisphosphate (PIP2) binding and the phosphorylation of threonine 567 (T567) are involved in the activation process that unmasks both membrane and actin binding sites. Here, we demonstrate that ezrin binding to PIP2, through its NH2-terminal domain, is required for T567 phosphorylation and thus for the conformational activation of ezrin in vivo. Furthermore, we found that the T567D mutation mimicking T567 phosphorylation bypasses the need for PIP2 binding for unmasking both membrane and actin binding sites. However, PIP2 binding and T567 phosphorylation are both necessary for the correct apical localization of ezrin and for its role in epithelial cell morphogenesis. These results establish that PIP2 binding and T567 phosphorylation act sequentially to allow ezrin to exert its cellular functions.

IMGT/JunctionAnalysis: the first tool for the analysis of the immunoglobulin and T cell receptor complex V--J and V--D--J JUNCTIONs

Abstract: Motivation: To create the enormous diversity of 1012 immunoglobulins (IG) and T cell receptors (TR) per individual, very complex mechanisms occur at the DNA level: the combinatorial diversity results from the junction of the variable (V), diversity (D) and joining (J) genes; the N-diversity represents the addition at random of nucleotides not encoded in the genome; and somatic hypermutations occur in IG rearranged sequences. The accurate annotation of the junction between V, D, J genes in rearranged IG and TR sequences represents therefore a huge challenge by its uniqueness and complexity. We developed IMGT/JunctionAnalysis to analyse automatically in detail the IG and TR junctions, according to the IMGT Scientific chart rules, based on the IMGT-ONTOLOGY concepts. Results: IMGT/JunctionAnalysis is the first tool for the detailed analysis of the IG and TR complex V--J and V--D--J JUNCTION(s). It delimits, at the nucleotide level, the genes resulting from the combinatorial diversity. It identifies accurately the D genes in the junctions of IG heavy (IGH), TR beta (TRB) and delta (TRD) chains. It delimits the palindromic P-REGION(s) and the N-REGION(s) resulting from the N-diversity. It evaluates the number of somatic hypermutations for each gene, within the JUNCTION. IMGT/JunctionAnalysis is capable of analysing, in a single run, an unlimited number of junctions from the same species (currently human or mouse) and from the same locus. Availability: IMGT/JunctionAnalysis is available from the IMGT Home page at http://imgt.cines.fr

Line Extraction in 2D Range Images for Mobile Robotics

Abstract: This paper presents a geometrical feature detection framework for use with conventional 2D laser rangefinders. This framework is composed of three main procedures: data pre-processing, breakpoint detection and line extraction. In data pre-processing, low-level data organization and processing are discussed, with emphasis to sensor bias compensation. Breakpoint detection allows to determine sequences of measurements which are not interrupted by scanning surface changing. Two breakpoint detectors are investigated, one based on adaptive thresholding, and the other on Kalman filtering. Implementation and tuning of both detectors are also investigated. Line extraction is performed to each continuous scan sequence in a range image by applying line kernels. We have investigated two classic kernels, commonly used in mobile robots, and our Split-and-Merge Fuzzy (SMF) line extractor. SMF employs fuzzy clustering in a split-and-merge framework without the need to guess the number of clusters. Qualitative and quantitative comparisons using simulated and real images illustrate the main characteristics of the framework when using different methods for breakpoint and line detection. These comparisons illustrate the characteristics of each estimator, which can be exploited according to the platform computing power and the application accuracy requirements.

Plasma wave detection of sub-terahertz and terahertz radiation by silicon field-effect transistors

Abstract: We report on experiments on photoresponse to sub-THz (120GHz) radiation of Si field-effect transistors (FETs) with nanometer and submicron gate lengths at 300K. The observed photoresponse is in agreement with predictions of the Dyakonov–Shur plasma wave detection theory. This is experimental evidence of the plasma wave detection by silicon FETs. The plasma wave parameters deduced from the experiments allow us to predict the nonresonant and resonant detection in THz range by nanometer size silicon devices—operating at room temperature.

Patterns and Universals of Adult Romantic Attachment Across 62 Cultural Regions Are Models of Self and of Other Pancultural Constructs

Abstract: As part of the International Sexuality Description Project, a total of 17,804 participants from 62 cultural regions completedthe RelationshipQuestionnaire(RQ), a self-reportmeasure of adult romanticattachment. Correlational analyses within each culture suggested that the Model of Self and the Model of Other scales of the RQ were psychometrically valid within most cultures. Contrary to expectations, the Model of Self and Model of Other dimensions of the RQ did not underlie the four-category model of attachment in the same way across all cultures. Analyses of specific attachment styles revealed that secure romantic attachment was normative in 79% of cultures and that preoccupied romantic attachment was particularly prevalent in East Asian cultures. Finally, the romantic attachment profiles of individual nations were correlated with sociocultural indicators in ways that supported evolutionary theories of romantic attachment and basic human mating strategies.

Stable benefit of embryonic stem cell therapy in myocardial infarction

Abstract: Conventional therapies for myocardial infarction attenuate disease progression without contributing significantly to repair. Because of the capacity for de novo cardiogenesis, embryonic stem cells ...

Did something decay, evaporate, or annihilate during Big Bang nucleosynthesis?

Abstract: Results of a detailed examination of the cascade nucleosynthesis resulting from the putative hadronic decay, evaporation, or annihilation of a primordial relic during the big bang nucleosynthesis (BBN) era are presented. It is found that injection of energetic nucleons around cosmic time ${10}^{3}\text{ }\text{ }\mathrm{s}$ may lead to an observationally favored reduction of the primordial $^{7}\mathrm{L}\mathrm{i}/\mathrm{H}$ yield by a factor 2--3. Moreover, such sources also generically predict the production of the $^{6}\mathrm{L}\mathrm{i}$ isotope with magnitude close to the as yet unexplained high $^{6}\mathrm{L}\mathrm{i}$ abundances in low-metallicity stars. The simplest of these models operates at a fractional contribution to the baryon density ${\ensuremath{\Omega}}_{b}{h}^{2}\ensuremath{\gtrsim}0.025$, slightly larger than that inferred from standard BBN. Though further study is required, such sources, as, for example, due to the decay of the next-to-lightest supersymmetric particle into GeV gravitinos or the decay of an unstable gravitino in the TeV range of abundance ${\ensuremath{\Omega}}_{\stackrel{\texttildelow{}}{G}}{h}^{2}\ensuremath{\sim}5\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}4}$ show promise to explain both the $^{6}\mathrm{L}\mathrm{i}$ and $^{7}\mathrm{L}\mathrm{i}$ abundances in low-metallicity stars.

Precise determination of the neutral Higgs boson masses in the MSSM

Abstract: We present the implementation of the radiative corrections of the Higgs sector in three public computer codes for the evaluation of the particle spectrum in the Minimal Supersymmetric Standard Model, Softsusy, Spheno and SuSpect. We incorporate the full one-loop corrections to the Higgs boson masses and the electroweak symmetry breaking conditions, as well as the two-loop corrections controlled by the strong gauge coupling and the Yukawa couplings of the third generation fermions. We include also the corrections controlled by the tau Yukawa coupling that we derived for completeness. The computation is consistently performed in the DRbar renormalisation scheme. In a selected number of MSSM scenarios, we study the effect of these corrections and analyse the impact of some higher order effects. By considering the renormalisation scheme and scale dependence, and the effect of the approximation of zero external momentum in the two-loop corrections, we estimate the theoretical uncertainty on the lighter Higgs boson mass to be 3 to 5 GeV. The uncertainty on Mh due to the experimental error in the measurement of the SM input parameters is approximately of the same size. Finally, we discuss the phenomenological consequences, using the latest value of the top quark mass. We find, in particular, that the most conservative upper bound on the lighter Higgs boson mass in the general MSSM is Mh < 152 GeV and that there is no lower bound on the parameter tan(beta) from non-observation of the MSSM Higgs bosons at LEP2.