Institution
University of Münster
Education•Münster, Germany•
About: University of Münster is a education organization based out in Münster, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 35609 authors who have published 69059 publications receiving 2278534 citations. The organization is also known as: University of Munster & University of Muenster.
Topics: Population, Transplantation, Lithium, Mass spectrometry, Electrolyte
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TL;DR: The data indicate that in mammary epithelial cells the vast majority of CD44 interacts with annexin II in lipid rafts in a cholesterol-dependent manner and these CD44-containing lipid microdomains interact with the underlying actin cytoskeleton.
Abstract: CD44, the major cell surface receptor for hyaluronic acid (HA), was shown to localize to detergent-resistant cholesterol-rich microdomains, called lipid rafts, in fibroblasts and blood cells. Here, we have investigated the molecular environment of CD44 within the plane of the basolateral membrane of polarized mammary epithelial cells. We show that CD44 partitions into lipid rafts that contain annexin II at their cytoplasmic face. Both CD44 and annexin II were released from these lipid rafts by sequestration of plasma membrane cholesterol. Partition of annexin II and CD44 to the same type of lipid rafts was demonstrated by cross-linking experiments in living cells. First, when CD44 was clustered at the cell surface by anti-CD44 antibodies, annexin II was recruited into the cytoplasmic leaflet of CD44 clusters. Second, the formation of intracellular, submembranous annexin II-p11 aggregates caused by expression of a trans-dominant mutant of annexin II resulted in coclustering of CD44. Moreover, a frequent redirection of actin bundles to these clusters was observed. These basolateral CD44/annexin II-lipid raft complexes were stabilized by addition of GTPgammaS or phalloidin in a semipermeabilized and cholesterol-depleted cell system. The low lateral mobility of CD44 in the plasma membrane, as assessed with fluorescent recovery after photobleaching (FRAP), was dependent on the presence of plasma membrane cholesterol and an intact actin cytoskeleton. Disruption of the actin cytoskeleton dramatically increased the fraction of CD44 which could be recovered from the light detergent-insoluble membrane fraction. Taken together, our data indicate that in mammary epithelial cells the vast majority of CD44 interacts with annexin II in lipid rafts in a cholesterol-dependent manner. These CD44-containing lipid microdomains interact with the underlying actin cytoskeleton.
399 citations
01 Jan 2001
TL;DR: The book begins with the biochemistry of testosterone, its biosynthesis, metabolism and mechanisms of action in target organs, and the possible role of androgens in the development of prostatic hypertrophy and carcinoma.
Abstract: Preface 1. The medical and cultural history of testosterone and the testes Eberhard Nieschlag and Susan Nieschlag 2. Testosterone: biosynthesis, transport, metabolism and (non-genomic) actions C. Marc Luetjens and Gerhard F. Weinbauer 3. Pathophysiology of the androgen receptor Olaf Hiort, R. Werner and Michael Zitzmann 4. Methodology for measuring testosterone, DHT and SHBG in a clinical setting Manuela Simoni, Flaminia Fanelli, Laura Roli and Uberto Pagotto 5. The behavioral correlates of testosterone John Bancroft 6. The role of testosterone in spermatogenesis Liza O'Donnell and Robert I. McLachlan 7. Androgens and hair: a biological paradox with clinical consequences Valerie Anne Randall 8. Testosterone and bone Dirk Vanderschueren, Mieke Sinnesael, E. Gielen, F. Claessens and S. Boonen 9. Androgens effects on the skeletal muscle Shalender Bhasin, Ravi Jasuja, Carlo Serra, Rajan Singh, Thomas W. Storer, Wen Guo, Thomas G. Travison and Shezad Basaria 10. Testosterone and cardiovascular disease Kevin S. Channer and T. Hugh Jones 11. Testosterone, obesity, diabetes and the metabolic syndrome T. Hugh Jones and Kevin S. Channer 12. Testosterone and erection Mario Maggi and Hermann M. Behre 13. Testosterone and the prostate John T. Isaacs and Samuel R. Denmeade 14. Clinical use of testosterone in hypogonadism and other conditions Eberhard Nieschlag and Hermann M. Behre 15. Testosterone preparations for clinical use in males Hermann M. Behre and Eberhard Nieschlag 16. Androgens in male senescence Jean-Marc Kaufman, Guy T'Sojen and Alex Verleulen 17. Androgen therapy in non-gonadal disease David J. Handelsman 18. Review of guidelines on diagnosis and treatment of testosterone deficiency Ronald S. Swerdloff and Christina C. L. Wang 19. Pathophysiology of estrogen action in men Vincenzo Rochira, Daniele Santi and Cesare Carani 20. Dehydroepiandrosterone (DHEA) and androstenedione Bruno Allolio, Wiebke Arlt and Stefanie Hahner 21. The state-of-the-art in the development of selective androgen receptor modulators (SARMs) Ravi Jasuja, M. Zacharov and Shalender Bhasin 22. The essential role of testosterone in hormonal male contraception Eberhard Nieschlag and Hermann M. Behre 23. Testosterone use in women Susan R. Davis 24. Detection of illegal use of androgens and SARMs Wilhelm Schanzer and Mario Thevis 25. Clinical effects of doping with anabolic steroids Elena Vorona and Eberhard Nieschlag Index.
399 citations
TL;DR: It is suggested that during inflammation, interaction of DC with small HA fragments induce DC maturation, which does not involve the HA receptors CD44 or the receptor for hyaluronan-mediated motility.
Abstract: The extracellular matrix component hyaluronan (HA) exists physiologically as a high m.w. polymer but is cleaved at sites of inflammation, where it will be contacted by dendritic cells (DC). To determine the effects of HA on DC, HA fragments of different size were established. Only small HA fragments of tetra- and hexasaccharide size (sHA), but not of intermediate size (m.w. 80, 000-200,000) or high m.w. HA (m.w. 1,000,000-600,000) induced immunophenotypic maturation of human monocyte-derived DC (up-regulation of HLA-DR, B7-1/2, CD83, down-regulation of CD115). Likewise, only sHA increased DC production of the cytokines IL-1beta, TNF-alpha, and IL-12 as well as their allostimulatory capacity. These effects were highly specific for sHA, because they were not induced by other glycosaminoglycans such as chondroitin sulfate or heparan sulfate or their fragmentation products. Interestingly, sHA-induced DC maturation does not involve the HA receptors CD44 or the receptor for hyaluronan-mediated motility, because DC from CD44-deficient mice and wild-type mice both responded similarly to sHA stimulation, whereas the receptor for hyaluronan-mediated motility is not detectable in DC. However, TNF-alpha is an essential mediator of sHA-induced DC maturation as shown by blocking studies with a soluble TNFR1. These findings suggest that during inflammation, interaction of DC with small HA fragments induce DC maturation.
398 citations
Jamia Millia Islamia1, Vietnam Academy of Science and Technology2, Hanoi University of Science3, Saitama University4, Aarhus University5, University of California, Santa Barbara6, Commissariat à l'énergie atomique et aux énergies alternatives7, University of Münster8, University of Connecticut9, University of Manchester10, Indian Institute of Technology Guwahati11, Leiden University12, Northwestern University13, Federal University of Paraíba14, Centre national de la recherche scientifique15, Universidade Federal do ABC16, University of Southampton17, Argonne National Laboratory18, Karlsruhe Institute of Technology19, University of Mainz20, Technische Universität München21, Max Planck Society22, Heidelberg University23, University of Tübingen24, Massachusetts Institute of Technology25, Durham University26, University of California, San Diego27, C. N. Yang Institute for Theoretical Physics28, Moscow Institute of Physics and Technology29, Russian Academy of Sciences30, University of Sydney31, University of Copenhagen32, Université libre de Bruxelles33, Paris Diderot University34, Niels Bohr Institute35, Estácio S.A.36, CERN37, University of California, Santa Cruz38, Institute on Taxation and Economic Policy39, University of Bern40, Institute for Advanced Study41, RWTH Aachen University42, Chinese Academy of Sciences43, East China University of Science and Technology44, University of Chicago45, Autonomous University of Madrid46, King's College London47, INAF48, Lawrence Berkeley National Laboratory49, University of Bari50, Istituto Nazionale di Fisica Nucleare51, University of Geneva52, Petersburg Nuclear Physics Institute53, University of Genoa54, Kapteyn Astronomical Institute55, Fermilab56, Spanish National Research Council57, Oak Ridge National Laboratory58, University of California, Berkeley59, École Polytechnique Fédérale de Lausanne60, University of Paris61, University of Zurich62, Mitchell Institute63, Tohoku University64, Princeton University65, Shimane University66, University of Maryland, College Park67, Dresden University of Technology68
TL;DR: A comprehensive review of keV-scale neutrino Dark Matter can be found in this paper, where the role of active neutrinos in particle physics, astrophysics, and cosmology is reviewed.
Abstract: We present a comprehensive review of keV-scale sterile neutrino Dark Matter, collecting views and insights from all disciplines involved—cosmology, astrophysics, nuclear, and particle physics—in each case viewed from both theoretical and experimental/observational perspectives. After reviewing the role of active neutrinos in particle physics, astrophysics, and cosmology, we focus on sterile neutrinos in the context of the Dark Matter puzzle. Here, we first review the physics motivation for sterile neutrino Dark Matter, based on challenges and tensions in purely cold Dark Matter scenarios. We then round out the discussion by critically summarizing all known constraints on sterile neutrino Dark Matter arising from astrophysical observations, laboratory experiments, and theoretical considerations. In this context, we provide a balanced discourse on the possibly positive signal from X-ray observations. Another focus of the paper concerns the construction of particle physics models, aiming to explain how sterile neutrinos of keV-scale masses could arise in concrete settings beyond the Standard Model of elementary particle physics. The paper ends with an extensive review of current and future astrophysical and laboratory searches, highlighting new ideas and their experimental challenges, as well as future perspectives for the discovery of sterile neutrinos.
398 citations
University of Geneva1, University of Helsinki2, Katholieke Universiteit Leuven3, University of Washington4, University of Wisconsin-Madison5, Heidelberg University6, German Cancer Research Center7, University of Nottingham8, VU University Amsterdam9, University of California, Irvine10, University of California, San Francisco11, French Institute of Health and Medical Research12, Harvard University13, Maine Medical Center14, University of Turin15, National Institutes of Health16, University of Texas Southwestern Medical Center17, University of Lausanne18, University of Missouri19, École Polytechnique Fédérale de Lausanne20, Uppsala University21, University of Arkansas for Medical Sciences22, University of Bern23, University of Virginia24, Imperial College London25, University of California, San Diego26, University College London27, Flanders Institute for Biotechnology28, University of Oxford29, University of California, Los Angeles30, University of Texas MD Anderson Cancer Center31, University of Toronto32, University of Illinois at Chicago33, University of Amsterdam34, George Washington University35, University of Liège36, University of Eastern Finland37, Ludwig Institute for Cancer Research38, Indiana University39, University of Edinburgh40, Maastricht University41, Loyola University Medical Center42, National Scientific and Technical Research Council43, University of Bari44, University of Fribourg45, Ohio State University46, University of Melbourne47, University of Antwerp48, University of Münster49
TL;DR: In vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis are described and critical aspects that are relevant for their execution and proper interpretation are highlighted.
Abstract: The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.
397 citations
Authors
Showing all 36075 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Hyun-Chul Kim | 176 | 4076 | 183227 |
| Klaus Müllen | 164 | 2125 | 140748 |
| Giacomo Bruno | 158 | 1687 | 124368 |
| Anders M. Dale | 156 | 823 | 133891 |
| Holger J. Schünemann | 141 | 810 | 113169 |
| Joachim Heinrich | 136 | 1309 | 76887 |
| Markus Merschmeyer | 132 | 1188 | 84975 |
| Klaus Ley | 129 | 495 | 57964 |
| Robert W. Mahley | 128 | 363 | 60774 |
| Robert J. Kurman | 127 | 397 | 60277 |
| Bart Barlogie | 126 | 779 | 57803 |
| Thomas Schwarz | 123 | 701 | 54560 |
| Carlos Caldas | 122 | 547 | 73840 |
| Klaus Weber | 121 | 524 | 60346 |
| Andrey L. Rogach | 117 | 576 | 46820 |