University of Münster

About: University of Münster is a education organization based out in Münster, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 35609 authors who have published 69059 publications receiving 2278534 citations. The organization is also known as: University of Munster & University of Muenster.

Chromosome localization in normal human cells and neuroblastomas of a gene related to c- myc

Abstract: Cellular oncogenes comprise a class of genes whose aberrant expression or function may be involved in the development of tumours1. Indeed, several naturally occurring animal and human tumours are associated with consistent alterations in the structure or genomic position of particular cellular oncogenes2–4. Recently, we isolated a DNA segment having limited similarity to c-myc (termed N-myc) from a human neuroblastoma cell line5. Although N-myc was present as a single copy in normal cells, it was selectively amplified up to 140-fold in tumour cells from human neuroblastomas5. Now, we have used somatic cell hybrids to show that N-myc is normally localized on the distal short arm of chromosome 2, and in situ hybridization to localize N-myc to chromosome 2p23–24. Further, in situ hybridization localizes amplified N-myc in neuroblastoma cells to homogeneously staining regions (HSRs) on different chromosomes. Thus, our results suggest that amplification and translocation of N-myc may be interrelated processes associated with human neuroblastoma, and demonstrate that lhe site of N-myc amplification is quite variable and bears no apparent relationship to either the normal single-copy locus or recognized sites of non-random chromosome alteration in human neuroblastoma.

Managing uncertainty in moving objects databases

Abstract: This article addresses the problem of managing Moving Objects Databases (MODs) which capture the inherent imprecision of the information about the moving object's location at a given time. We deal systematically with the issues of constructing and representing the trajectories of moving objects and querying the MOD. We propose to model an uncertain trajectory as a three-dimensional (3D) cylindrical body and we introduce a set of novel but natural spatio-temporal operators which capture the uncertainty and are used to express spatio-temporal range queries. We devise and analyze algorithms for processing the operators and demonstrate that the model incorporates the uncertainty in a manner which enables efficient querying, thus striking a balance between the modeling power and computational efficiency. We address some implementation aspects which we experienced in our DOMINO project, as a part of which the operators that we introduce have been implemented. We also report on some experimental observations of a practical relevance.

Paternal age and reproduction

Abstract: BACKGROUND Due to various sociological factors, couples in developed countries are increasingly delaying childbearing. Besides ethical, economical and sociological issues, this trend presents us with several complex problems in reproduction. Although it is well-known that maternal age has a negative effect on fertility and increases the risk of adverse outcome during pregnancy and in offspring, the paternal influence on these outcomes is less well researched and not well-known. METHODS We performed a systematic search of PubMed, and retrieved original articles and review articles to update our previous survey in this journal. RESULTS This review highlights the link between male age and genetic abnormalities in the germ line and summarizes the knowledge about the effects of paternal age on reproductive function and outcome. Increasing paternal age can be associated with decreasing androgen levels, decreased sexual activity, alterations of testicular morphology and a deterioration of semen quality (volume, motility, morphology). Increased paternal age has an influence on DNA integrity of sperm, increases telomere length in spermatozoa and is suggested to have epigenetic effects. These changes may, at least in part, be responsible for the association of paternal age over 40 years with reduced fertility, an increase in pregnancy-associated complications and adverse outcome in the offspring. CONCLUSION Although higher maternal age can be an indication for intensive prenatal diagnosis, including invasive diagnostics, consideration of the available evidence suggests that paternal age itself, however, provides no rationale for invasive procedures.

Display Blindness: The Effect of Expectations on Attention towards Digital Signage

Abstract: In this paper we show how audience expectations towards what is presented on public displays can correlate with their attention towards these displays. Similar to the effect of Banner Blindness on the Web, displays for which users expect uninteresting content (e.g. advertisements) are often ignored. We investigate this effect in two studies. In the first, interviews with 91 users at 11 different public displays revealed that for most public displays, the audience expects boring advertisements and so ignores the displays. This was exemplified by the inclusion of two of our own displays. One, the iDisplay, which showed information for students, was looked at more often than the other (MobiDiC) which showed coupons for shops. In a second study, we conducted repertory grid interviews with 17 users to identify the dimensions that users believe to influence whether they look at public displays. We propose possible solutions to overcome this "Display Blindness" and increase audience attention towards public displays.