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University of Münster

EducationMünster, Germany
About: University of Münster is a education organization based out in Münster, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 35609 authors who have published 69059 publications receiving 2278534 citations. The organization is also known as: University of Munster & University of Muenster.


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Journal ArticleDOI
TL;DR: This tutorial review aims at offering a didactic overview of organocatalytic umpolung and should serve as an inspiration for further progress in this field.
Abstract: The umpolung strategy encompasses all the methods that make organic molecules react in an inverse manner compared to their innate polarity-driven reactivity. This concept entered the field of organocatalysis when it was recognized that N-heterocyclic carbenes (NHCs) can provide catalytic access to acyl anion equivalents. Since then, tremendous efforts have followed to develop a broad variety of NHC-catalyzed reactions. In addition to this, more recent research developments have shown that other families of organocatalysts are also able to mediate transformations in which inversion of polarity is involved. This tutorial review aims at offering a didactic overview of organocatalytic umpolung and should serve as an inspiration for further progress in this field.

1,063 citations

Proceedings ArticleDOI
13 Jun 2017
TL;DR: This work describes the ongoing collection of the “something-something” database of video prediction tasks whose solutions require a common sense understanding of the depicted situation, and describes the challenges in crowd-sourcing this data at scale.
Abstract: Neural networks trained on datasets such as ImageNet have led to major advances in visual object classification. One obstacle that prevents networks from reasoning more deeply about complex scenes and situations, and from integrating visual knowledge with natural language, like humans do, is their lack of common sense knowledge about the physical world. Videos, unlike still images, contain a wealth of detailed information about the physical world. However, most labelled video datasets represent high-level concepts rather than detailed physical aspects about actions and scenes. In this work, we describe our ongoing collection of the “something-something” database of video prediction tasks whose solutions require a common sense understanding of the depicted situation. The database currently contains more than 100,000 videos across 174 classes, which are defined as caption-templates. We also describe the challenges in crowd-sourcing this data at scale.

1,062 citations

Journal ArticleDOI
Elena Aprile1, Jelle Aalbers2, F. Agostini, M. Alfonsi3, F. D. Amaro4, M. Anthony1, F. Arneodo5, P. Barrow6, Laura Baudis6, Boris Bauermeister7, M. L. Benabderrahmane5, T. Berger8, P. A. Breur2, April S. Brown2, Ethan Brown8, S. Bruenner9, Giacomo Bruno, Ran Budnik10, L. Bütikofer11, J. Calvén7, João Cardoso4, M. Cervantes12, D. Cichon9, D. Coderre11, Auke-Pieter Colijn2, Jan Conrad7, Jean-Pierre Cussonneau13, M. P. Decowski2, P. de Perio1, P. Di Gangi14, A. Di Giovanni5, Sara Diglio13, G. Eurin9, J. Fei15, A. D. Ferella7, A. Fieguth16, W. Fulgione, A. Gallo Rosso, Michelle Galloway6, F. Gao1, M. Garbini14, Robert Gardner17, C. Geis3, Luke Goetzke1, L. Grandi17, Z. Greene1, C. Grignon3, C. Hasterok9, E. Hogenbirk2, J. Howlett1, R. Itay10, B. Kaminsky11, Shingo Kazama6, G. Kessler6, A. Kish6, H. Landsman10, R. F. Lang12, D. Lellouch10, L. Levinson10, Qing Lin1, Sebastian Lindemann9, Manfred Lindner9, F. Lombardi15, J. A. M. Lopes4, A. Manfredini10, I. Mariș5, T. Marrodán Undagoitia9, Julien Masbou13, F. V. Massoli14, D. Masson12, D. Mayani6, M. Messina1, K. Micheneau13, A. Molinario, K. Morâ7, M. Murra16, J. Naganoma18, Kaixuan Ni15, Uwe Oberlack3, P. Pakarha6, Bart Pelssers7, R. Persiani13, F. Piastra6, J. Pienaar12, V. Pizzella9, M.-C. Piro8, Guillaume Plante1, N. Priel10, L. Rauch9, S. Reichard6, C. Reuter12, B. Riedel17, A. Rizzo1, S. Rosendahl16, N. Rupp9, R. Saldanha17, J.M.F. dos Santos4, Gabriella Sartorelli14, M. Scheibelhut3, S. Schindler3, J. Schreiner9, Marc Schumann11, L. Scotto Lavina19, M. Selvi14, P. Shagin18, E. Shockley17, Manuel Gameiro da Silva4, H. Simgen9, M. V. Sivers11, A. Stein20, S. Thapa17, Dominique Thers13, A. Tiseni2, Gian Carlo Trinchero, C. Tunnell17, M. Vargas16, N. Upole17, Hui Wang20, Zirui Wang, Yuehuan Wei6, Ch. Weinheimer16, J. Wulf6, J. Ye15, Yanxi Zhang1, T. Zhu1 
TL;DR: The first dark matter search results from XENON1T, a ∼2000-kg-target-mass dual-phase (liquid-gas) xenon time projection chamber in operation at the Laboratori Nazionali del Gran Sasso in Italy, are reported and a profile likelihood analysis shows that the data are consistent with the background-only hypothesis.
Abstract: We report the first dark matter search results from XENON1T, a ∼2000-kg-target-mass dual-phase (liquid-gas) xenon time projection chamber in operation at the Laboratori Nazionali del Gran Sasso in Italy and the first ton-scale detector of this kind The blinded search used 342 live days of data acquired between November 2016 and January 2017 Inside the (1042±12)-kg fiducial mass and in the [5,40] keVnr energy range of interest for weakly interacting massive particle (WIMP) dark matter searches, the electronic recoil background was (193±025)×10-4 events/(kg×day×keVee), the lowest ever achieved in such a dark matter detector A profile likelihood analysis shows that the data are consistent with the background-only hypothesis We derive the most stringent exclusion limits on the spin-independent WIMP-nucleon interaction cross section for WIMP masses above 10 GeV/c2, with a minimum of 77×10-47 cm2 for 35-GeV/c2 WIMPs at 90% CL

1,061 citations

Journal ArticleDOI
TL;DR: Physicochemical data (electronics, sterics, bond strength) of NHCs that are essential for the design, application, and mechanistic understanding of N-Heterocyclic carbenes in catalysis are provided.
Abstract: Quantification and variation of characteristic properties of different ligand classes is an exciting and rewarding research field. N-Heterocyclic carbenes (NHCs) are of special interest since their electron richness and structure provide a unique class of ligands and organocatalysts. Consequently, they have found widespread application as ligands in transition-metal catalysis and organometallic chemistry, and as organocatalysts in their own right. Herein we provide an overview on physicochemical data (electronics, sterics, bond strength) of NHCs that are essential for the design, application, and mechanistic understanding of NHCs in catalysis.

1,047 citations

Journal ArticleDOI
27 May 2010-Nature
TL;DR: It is shown with genetic experiments in mouse and zebrafish that ephrin-B2, a transmembrane ligand for Eph receptor tyrosine kinases, promotes sprouting behaviour and motility in the angiogenic endothelium, and shows that full VEGFR3 signalling is coupled to receptor internalization.
Abstract: In development, tissue regeneration or certain diseases, angiogenic growth leads to the expansion of blood vessels and the lymphatic vasculature. This involves endothelial cell proliferation as well as angiogenic sprouting, in which a subset of cells, termed tip cells, acquires motile, invasive behaviour and extends filopodial protrusions. Although it is already appreciated that angiogenesis is triggered by tissue-derived signals, such as vascular endothelial growth factor (VEGF) family growth factors, the resulting signalling processes in endothelial cells are only partly understood. Here we show with genetic experiments in mouse and zebrafish that ephrin-B2, a transmembrane ligand for Eph receptor tyrosine kinases, promotes sprouting behaviour and motility in the angiogenic endothelium. We link this pro-angiogenic function to a crucial role of ephrin-B2 in the VEGF signalling pathway, which we have studied in detail for VEGFR3, the receptor for VEGF-C. In the absence of ephrin-B2, the internalization of VEGFR3 in cultured cells and mutant mice is defective, which compromises downstream signal transduction by the small GTPase Rac1, Akt and the mitogen-activated protein kinase Erk. Our results show that full VEGFR3 signalling is coupled to receptor internalization. Ephrin-B2 is a key regulator of this process and thereby controls angiogenic and lymphangiogenic growth.

1,046 citations


Authors

Showing all 36075 results

NameH-indexPapersCitations
Hyun-Chul Kim1764076183227
Klaus Müllen1642125140748
Giacomo Bruno1581687124368
Anders M. Dale156823133891
Holger J. Schünemann141810113169
Joachim Heinrich136130976887
Markus Merschmeyer132118884975
Klaus Ley12949557964
Robert W. Mahley12836360774
Robert J. Kurman12739760277
Bart Barlogie12677957803
Thomas Schwarz12370154560
Carlos Caldas12254773840
Klaus Weber12152460346
Andrey L. Rogach11757646820
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023253
2022831
20213,683
20203,499
20193,236
20182,918