University of Münster

About: University of Münster is a education organization based out in Münster, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 35609 authors who have published 69059 publications receiving 2278534 citations. The organization is also known as: University of Munster & University of Muenster.

Performance of the ALICE experiment at the CERN LHC

Abstract: ALICE is the heavy-ion experiment at the CERN Large Hadron Collider. The experiment continuously took data during the first physics campaign of the machine from fall 2009 until early 2013, using proton and lead-ion beams. In this paper we describe the running environment and the data handling procedures, and discuss the performance of the ALICE detectors and analysis methods for various physics observables.

Continuous Lenalidomide Treatment for Newly Diagnosed Multiple Myeloma

Abstract: The median follow-up period was 30 months. The median progression-free survival was significantly longer with MPR-R (31 months) than with MPR (14 months; hazard ratio, 0.49; P<0.001) or MP (13 months; hazard ratio, 0.40; P <0.001). Response rates were superior with MPR-R and MPR (77% and 68%, respectively, vs. 50% with MP; P<0.001 and P = 0.002, respectively, for the comparison with MP). The progression-free survival benefit associated with MPR-R was noted in patients 65 to 75 years of age but not in those older than 75 years of age (P = 0.001 for treatment-by-age interaction). After induction therapy, a landmark analysis showed a 66% reduction in the rate of progression with MPR-R (hazard ratio for the comparison with MPR, 0.34; P<0.001) that was age-independent. During induction therapy, the most frequent adverse events were hematologic; grade 4 neutropenia was reported in 35%, 32%, and 8% of the patients in the MPR-R, MPR, and MP groups, respectively. The 3-year rate of second primary tumors was 7% with MPR-R, 7% with MPR, and 3% with MP. Conclusions MPR-R significantly prolonged progression-free survival in patients with newly di agnosed multiple myeloma who were ineligible for transplantation, with the great est benefit observed in patients 65 to 75 years of age. (Funded by Celgene; MM-015 ClinicalTrials.gov number, NCT00405756.)

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

Abstract: Myofibroblasts are the major source of extracellular matrix components that accumulate during tissue fibrosis, and hepatic stellate cells (HSCs) are believed to be the major source of myofibroblasts in the liver. To date, robust systems to genetically manipulate these cells have not been developed. We report that Cre under control of the promoter of Pdgfrb (Pdgfrb-Cre) inactivates loxP-flanked genes in mouse HSCs with high efficiency. We used this system to delete the gene encoding α(v) integrin subunit because various α(v)-containing integrins have been suggested as central mediators of fibrosis in multiple organs. Such depletion protected mice from carbon tetrachloride-induced hepatic fibrosis, whereas global loss of β₃, β₅ or β₆ integrins or conditional loss of β₈ integrins in HSCs did not. We also found that Pdgfrb-Cre effectively targeted myofibroblasts in multiple organs, and depletion of the α(v) integrin subunit using this system was protective in other models of organ fibrosis, including pulmonary and renal fibrosis. Pharmacological blockade of α(v)-containing integrins by a small molecule (CWHM 12) attenuated both liver and lung fibrosis, including in a therapeutic manner. These data identify a core pathway that regulates fibrosis and suggest that pharmacological targeting of all α(v) integrins may have clinical utility in the treatment of patients with a broad range of fibrotic diseases.

Narcissistic admiration and rivalry: disentangling the bright and dark sides of narcissism.

Abstract: We present a process model that distinguishes 2 dimensions of narcissism: admiration and rivalry. We propose that narcissists' overarching goal of maintaining a grandiose self is pursued by 2 separate pathways, characterized by distinct cognitive, affective-motivational, and behavioral processes. In a set of 7 studies, we validated this 2-dimensional model using the newly developed Narcissistic Admiration and Rivalry Questionnaire (NARQ). We showed that narcissistic admiration and rivalry are positively correlated dimensions, yet they have markedly different nomological networks and distinct intra- and interpersonal consequences. The NARQ showed the hypothesized 2-dimensional multifaceted structure as well as very good internal consistencies (Study 1, N = 953), stabilities (Study 2, N = 93), and self-other agreements (Study 3, N = 96). Narcissistic admiration and rivalry showed unique relations to the Narcissistic Personality Inventory (NPI), the Big Five, self-esteem, pathological narcissism, and other narcissism-related traits like Machiavellianism, psychopathy, self-enhancement, and impulsivity (Study 4, Ns = 510-1,814). Despite the positive relation between admiration and rivalry, the 2 differentially predicted general interpersonal orientations and reactions to transgressions in friendships and romantic relationships (Study 5, N = 1,085), interpersonal perceptions during group interactions (Study 6, N = 202), and observed behaviors in experimental observations (Study 7, N = 96). For all studies, the NARQ outperformed the standard measure of narcissism, the NPI, in predicting outcome measures. Results underscore the utility of a 2-dimensional conceptualization and measurement of narcissism.