Institution
University of Münster
Education•Münster, Germany•
About: University of Münster is a education organization based out in Münster, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 35609 authors who have published 69059 publications receiving 2278534 citations. The organization is also known as: University of Munster & University of Muenster.
Topics: Population, Transplantation, Lithium, Mass spectrometry, Electrolyte
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TL;DR: A conceptually novel pyrrole synthesis is reported, efficiently merging enamines and (unactivated) alkynes under oxidative conditions.
Abstract: A conceptually novel pyrrole synthesis is reported, efficiently merging enamines and (unactivated) alkynes under oxidative conditions. In an intermolecular Rh catalyzed process, the challenging allylic sp3 C−H activation of the enamine substrates is followed by the cyclization with the alkyne (R3 = CO2R). Alternatively, in some cases (R3 = CN), the enamine can be utilized for a vinylic sp2 C−H activation. A total of 17 examples with yields above 60% is presented, together with the results of an initial mechanistic investigation.
512 citations
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TL;DR: In this article, a set of hypotheses regarding these relations is generated and tested next, using data from a study with 331 German students, who completed both the Rokeach Value Survey (RVS) and the Freiburg Personality Inventory (FPI), measuring ten primary and two secondary personality variables, namely extraversion and emotionality.
Abstract: Personality and differential psychology have paid little attention to values research. Consequently, the constructs used in these subdisciplines have developed independently, and evidence regarding the relations of personality to values is minimal. This study seeks to advance our understanding of these relations and to arrive at a theoretical integration of constructs. Starting from recent developments in values theory (Schwartz, 1992; Schwartz and Bilsky, 1987, 1990) and drawing on Maslow's (1955) distinction between ‘deficiency’ and ‘growth’ needs, we elaborate theoretical links between personality and values with special emphasis on structural relations. A set of hypotheses regarding these relations is generated and tested next, using data from a study with 331 German students. These students completed both the Rokeach Value Survey (RVS) and the Freiburg Personality Inventory (FPI), measuring ten primary and two secondary personality variables, namely extraversion and emotionality. Joint Similarity Structure Analyses (SSAs) of values and personality variables were conducted. The findings reveal both meaningful and systematic associations of value priorities with personality variables, confirming the hypothesized structural relationships. The compatibility of our hypotheses with the complex findings of George (1954) using totally different indexes of both values (Allport–Vernon Study of Values) and personality (drawn from Eysenck and Guilford) further supports the theoretical connections proposed in this study.
512 citations
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Heidelberg University1, German Cancer Research Center2, University Hospital Heidelberg3, University of Zurich4, Medical University of Vienna5, Goethe University Frankfurt6, University of Bristol7, Otto-von-Guericke University Magdeburg8, University of Mannheim9, Saarland University10, University of Bonn11, Charité12, University of Cambridge13, University of Münster14
TL;DR: Compared with WHO grading, classification by individual and combined methylation classes more accurately identifies patients at high risk of disease progression in tumours with WHO grade I histology, and patients at lower risk of recurrence among WHO grade II tumours.
Abstract: Summary Background The WHO classification of brain tumours describes 15 subtypes of meningioma. Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III. Grading is based solely on histology, with an absence of molecular markers. Although the existing classification and grading approach is of prognostic value, it harbours shortcomings such as ill-defined parameters for subtypes and grading criteria prone to arbitrary judgment. In this study, we aimed for a comprehensive characterisation of the entire molecular genetic landscape of meningioma to identify biologically and clinically relevant subgroups. Methods In this multicentre, retrospective analysis, we investigated genome-wide DNA methylation patterns of meningiomas from ten European academic neuro-oncology centres to identify distinct methylation classes of meningiomas. The methylation classes were further characterised by DNA copy number analysis, mutational profiling, and RNA sequencing. Methylation classes were analysed for progression-free survival outcomes by the Kaplan-Meier method. The DNA methylation-based and WHO classification schema were compared using the Brier prediction score, analysed in an independent cohort with WHO grading, progression-free survival, and disease-specific survival data available, collected at the Medical University Vienna (Vienna, Austria), assessing methylation patterns with an alternative methylation chip. Findings We retrospectively collected 497 meningiomas along with 309 samples of other extra-axial skull tumours that might histologically mimic meningioma variants. Unsupervised clustering of DNA methylation data clearly segregated all meningiomas from other skull tumours. We generated genome-wide DNA methylation profiles from all 497 meningioma samples. DNA methylation profiling distinguished six distinct clinically relevant methylation classes associated with typical mutational, cytogenetic, and gene expression patterns. Compared with WHO grading, classification by individual and combined methylation classes more accurately identifies patients at high risk of disease progression in tumours with WHO grade I histology, and patients at lower risk of recurrence among WHO grade II tumours (p=0·0096) from the Brier prediction test). We validated this finding in our independent cohort of 140 patients with meningioma. Interpretation DNA methylation-based meningioma classification captures clinically more homogenous groups and has a higher power for predicting tumour recurrence and prognosis than the WHO classification. The approach presented here is potentially very useful for stratifying meningioma patients to observation-only or adjuvant treatment groups. We consider methylation-based tumour classification highly relevant for the future diagnosis and treatment of meningioma. Funding German Cancer Aid, Else Kroner-Fresenius Foundation, and DKFZ/Heidelberg Institute of Personalized Oncology/Precision Oncology Program.
511 citations
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TL;DR: This study for the first time provides substantial information about metabolism and excretion of corticosterone in urine and feces of mice and is the first demonstrating a significant impact of the animals' sex and the time of day.
510 citations
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TL;DR: In aging male patients, psychosomatic complaints and metabolic risk relate to testosterone in a symptom-specific manner, and there is no evidence that a uniform structure of testosterone concentrations and complaints exists within the cohort of elderly male patients.
Abstract: Context: Although attention and concern about health disorders in aging men have been growing, the structure of psychological and somatic complaints of actual patients, not population-based cohorts, has not been elucidated in relation to sex hormone patterns and metabolism. Objective: The objective of the study was investigation of factors influencing complaint structures in aging male patients. Design: This was a cross-sectional cohort study. Setting: The study was conducted in an andrological outpatient department. Patients: Subjects included 434 consecutive male patients aged 50–86 yr. Main Outcome Measures: The following hypotheses were measured: 1) psychosomatic complaints and metabolic factors in aging male patients are related to sex hormone levels in a symptom-specific manner, and 2) patients form subcohorts. Results: A clear-cut threshold for late-onset hypogonadism was not found; rather, prevalence of psychosomatic symptoms and metabolic risk factors accumulated with decreasing androgen levels. ...
510 citations
Authors
Showing all 36075 results
Name | H-index | Papers | Citations |
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Hyun-Chul Kim | 176 | 4076 | 183227 |
Klaus Müllen | 164 | 2125 | 140748 |
Giacomo Bruno | 158 | 1687 | 124368 |
Anders M. Dale | 156 | 823 | 133891 |
Holger J. Schünemann | 141 | 810 | 113169 |
Joachim Heinrich | 136 | 1309 | 76887 |
Markus Merschmeyer | 132 | 1188 | 84975 |
Klaus Ley | 129 | 495 | 57964 |
Robert W. Mahley | 128 | 363 | 60774 |
Robert J. Kurman | 127 | 397 | 60277 |
Bart Barlogie | 126 | 779 | 57803 |
Thomas Schwarz | 123 | 701 | 54560 |
Carlos Caldas | 122 | 547 | 73840 |
Klaus Weber | 121 | 524 | 60346 |
Andrey L. Rogach | 117 | 576 | 46820 |