Institution
University of Naples Federico II
Education•Naples, Campania, Italy•
About: University of Naples Federico II is a education organization based out in Naples, Campania, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 29291 authors who have published 68803 publications receiving 1920149 citations. The organization is also known as: Università degli Studi di Napoli Federico II & Naples University.
Topics: Population, Cancer, Medicine, Context (language use), Computer science
Papers published on a yearly basis
Papers
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TL;DR: The results suggest that endogenous NO modulates adjuvant arthritis, possibly by interfering with the activation of T‐lymphocytes and/or macrophages.
Abstract: 1. The role of endogenous nitric oxide (NO) in adjuvant arthritis in Lewis rats has been studied by use of L-arginine, the amino acid from which NO is synthesized, and NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NO synthase. Prolonged modulation (35 days) of the L-arginine: NO pathway in rats was achieved by dissolving test compounds in the drinking water (L-arginine: 3, 10 and 30 mg ml-1; L-NAME: 0.1, 1 and 10 mg ml-1). 2. Arthritis was exacerbated by L-arginine and suppressed by L-NAME in a dose-related fashion. Combined treatment with L-NAME (1 mg ml-1) and L-arginine (30 mg ml-1) did not modify the arthritis. 3. Reduced weight gain, which is a feature of adjuvant arthritis, was modified by these compounds so that L-arginine reduced weight gain whereas L-NAME increased weight gain compared with that in control animals. 4. D-Arginine (30 mg ml-1), NG-nitro-D-arginine methyl ester (D-NAME: 1 mg ml-1) and L-lysine (30 mg ml-1), an amino acid not involved in the generation of NO, were without effect on either arthritis or body weight gain. 5. Antigen-stimulated proliferation of T-lymphocytes as well as generation of nitrite (NO2-) and release of acid phosphatase from macrophages were all enhanced in L-arginine-treated arthritic rats and reduced in L-NAME-treated animals. 6. These results suggest that endogenous NO modulates adjuvant arthritis, possibly by interfering with the activation of T-lymphocytes and/or macrophages.
321 citations
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TL;DR: It is suggested that the microbiome plays a role in the maintenance of a healthy state in adulthood and is becoming increasingly more possible to develop novel diagnostic, prognostic and, most important, therapeutic strategies based on microbiome manipulation.
321 citations
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TL;DR: Celiac disease is associated with an increased risk for non-Hodgkin lymphoma, especially of T-cell type and primarily localized in the gut, however, the association does not represent a great enough risk to justify early mass screening for celiac disease.
Abstract: ContextCeliac disease is one of the most common lifelong disorders. Non-Hodgkin
lymphoma is a possible complication of celiac disease and may lead to a large
portion of lymphoma cases.ObjectiveTo quantify the risk for developing non-Hodgkin lymphoma of any primary
site associated with celiac disease.Design and SettingMulticenter, case-control study conducted between January 1996 and December
1999 throughout Italy.PatientsCases were older than 20 years (median, 57; range, 20-92 years) with
non-Hodgkin lymphoma of any primary site and histological type and were recruited
at the time of the diagnosis. Controls were healthy adults (2739 men and 2981
women) from the general population.Main Outcome MeasurePositive test result for class A serum antiendomysial antibody.ResultsCeliac disease was diagnosed in 6 (0.92%) of 653 patients with lymphoma.
Of the 6 cases, 3 were of B-cell and 3 were of T-cell origin. Four of 6 cases
had lymphoma primarily located in the gut. In the control group, 24 (0.42%)
had celiac disease. The odds ratio (adjusted for age and sex) for non-Hodgkin
lymphoma of any primary site associated with celiac disease was 3.1 (95% confidence
interval [CI], 1.3-7.6), 16.9 (95% CI, 7.4-38.7) for gut lymphoma, and 19.2
(95% CI, 7.9-46.6) for T-cell lymphoma, respectively. The risk for non-Hodgkin
lymphoma for the overall population, which was adjusted for age and sex, was
0.63% (95% CI, − 0.12% to 1.37%).ConclusionCeliac disease is associated with an increased risk for non-Hodgkin
lymphoma, especially of T-cell type and primarily localized in the gut. However,
the association does not represent a great enough risk to justify early mass
screening for celiac disease.
320 citations
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TL;DR: The data recorded by these instruments during their first and second observing runs are described, including the gravitational-wave strain arrays, released as time series sampled at 16384 Hz.
320 citations
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TL;DR: Thyroid hormone-activated mitochondrial mechanisms provide protection against excessive tissue dysfunction, including increased expression of uncoupling proteins, proteolytic enzymes and transcriptional coactivator PGC-1, and stimulate opening of permeability transition pores.
Abstract: Hypermetabolic state in hyperthyroidism is associated with tissue oxidative injury. Available data indicate that hyperthyroid tissues exhibit an increased ROS and RNS production. The increased mitochondrial ROS generation is a side effect of the enhanced level of electron carriers, by which hyperthyroid tissues increase their metabolic capacity. Investigations of antioxidant defence system have returned controversial results. Moreover, other thyroid hormone-linked biochemical changes increase tissue susceptibility to oxidative challenge, which exacerbates the injury and dysfunction they suffer under stressful conditions. Mitochondria, as a primary target for oxidative stress, might account for hyperthyroidism linked tissue dysfunction. This is consistent with the inverse relationship found between functional recovery of ischemic hyperthyroid hearts and mitochondrial oxidative damage and respiration impairment. However, thyroid hormone-activated mitochondrial mechanisms provide protection against excessive tissue dysfunction, including increased expression of uncoupling proteins, proteolytic enzymes and transcriptional coactivator PGC-1, and stimulate opening of permeability transition pores.
320 citations
Authors
Showing all 29740 results
Name | H-index | Papers | Citations |
---|---|---|---|
D. M. Strom | 176 | 3167 | 194314 |
Yang Gao | 168 | 2047 | 146301 |
Robert Stone | 160 | 1756 | 167901 |
Elio Riboli | 158 | 1136 | 110499 |
Barry J. Maron | 155 | 792 | 91595 |
H. Eugene Stanley | 154 | 1190 | 122321 |
Paul Elliott | 153 | 773 | 103839 |
Robert O. Bonow | 149 | 808 | 114836 |
Kai Simons | 147 | 426 | 93178 |
Peter Buchholz | 143 | 1181 | 92101 |
Martino Margoni | 141 | 2059 | 107829 |
H. A. Neal | 141 | 1903 | 115480 |
Luca Lista | 140 | 2044 | 110645 |
Pierluigi Paolucci | 138 | 1965 | 105050 |
Ari Helenius | 137 | 298 | 64789 |