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Institution

University of Naples Federico II

EducationNaples, Campania, Italy
About: University of Naples Federico II is a education organization based out in Naples, Campania, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 29291 authors who have published 68803 publications receiving 1920149 citations. The organization is also known as: Università degli Studi di Napoli Federico II & Naples University.


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Journal ArticleDOI
TL;DR: In this paper, the authors review what computer, in vitro, in vivo, and pharmacological experiments tell us about the accumulation and deposition of the oligomers of the (Aβ, tau), α-synuclein, IAPP, and superoxide dismutase 1 proteins, which have been the mainstream concept underlying Alzheimer's disease, Parkinson's disease (PD), type II diabetes (T2D), and amyotrophic lateral sclerosis (ALS) research.
Abstract: Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. Structural and dynamic characterization of all species along the pathways from monomers to fibrils is challenging by experimental and computational means because they involve intrinsically disordered proteins in most diseases. Yet understanding how amyloid species become toxic is the challenge in developing a treatment for these diseases. Here we review what computer, in vitro, in vivo, and pharmacological experiments tell us about the accumulation and deposition of the oligomers of the (Aβ, tau), α-synuclein, IAPP, and superoxide dismutase 1 proteins, which have been the mainstream concept underlying Alzheimer's disease (AD), Parkinson's disease (PD), type II diabetes (T2D), and amyotrophic lateral sclerosis (ALS) research, respectively, for many years.

300 citations

Journal ArticleDOI
TL;DR: Time-varying feedback coupling gains are considered, whose gradient is a function of the local synchronization error over each edge in the network, and it is shown that, under appropriate conditions, the strategy is indeed successful in guaranteeing the achievement of a common synchronous evolution for all oscillators in thenetwork.

300 citations

Journal ArticleDOI
TL;DR: Most obese subjects, independent of being affected by PCOS, have an abdominal form of obesity, however, abdominal fat excess may not be the only determinant of insulin resistance in PCOS.
Abstract: Context: Increased abdominal fat has been linked to insulin resistance and increased cardiovascular risk. Because many patients with polycystic ovary syndrome (PCOS) present abdominal obesity, it may be the cause of insulin resistance in this disorder. Setting: Fat quantity and distribution were evaluated by dual x-ray absorptiometry at the Departments of Clinical Medicine at the University of Palermo and the University of Naples, Italy. Patients: A total of 110 patients with PCOS and 112 weight-matched controls were studied. Anthropometric data, blood glucose, serum insulin, and testosterone were evaluated. Total, trunk, and central abdominal fat quantity were measured by total-body dual x-ray absorptiometry. Results: Compared with weight-matched controls, patients with PCOS had similar quantity of total and trunk fat but higher quantity of central abdominal fat. This difference was not observed when comparing obese PCOS and obese controls but depended on differences between overweight and normoweight pa...

300 citations

Journal ArticleDOI
TL;DR: The disturbed microstate syntax opens a novel physiological comparison of mental operations between patients and controls and might account for Bleuler's "double bookkeeping".
Abstract: In young, first-episode, productive, medication-naive patients with schizophrenia, EEG microstates (building blocks of mentation) tend to be shortened. Koenig et al. [Koenig, T., Lehmann, D., Merlo, M., Kochi, K., Hell, D., Koukkou, M., 1999. A deviant EEG brain microstate in acute, neuroleptic-naive schizophrenics at rest. European Archives of Psychiatry and Clinical Neuroscience 249, 205–211] suggested that shortening concerned specific microstate classes. Sequence rules (microstate concatenations, syntax) conceivably might also be affected. In 27 patients of the above type and 27 controls, from three centers, multichannel resting EEG was analyzed into microstates using k-means clustering of momentary potential topographies into four microstate classes (A–D). In patients, microstates were shortened in classes B and D (from 80 to 70 ms and from 94 to 82 ms, respectively), occurred more frequently in classes A and C, and covered more time in A and less in B. Topography differed only in class B where LORETA tomography predominantly showed stronger left and anterior activity in patients. Microstate concatenation (syntax) generally were disturbed in patients; specifically, the class sequence A→C→D→A predominated in controls, but was reversed in patients (A→D→C→A). In schizophrenia, information processing in certain classes of mental operations might deviate because of precocious termination. The intermittent occurrence might account for Bleuler's “double bookkeeping.” The disturbed microstate syntax opens a novel physiological comparison of mental operations between patients and controls.

300 citations

Journal ArticleDOI
TL;DR: Two important categories of natural plant biostimulants mentioned in this web article were two important categories such as humic acids and seaweed extracts, and their action on plants was proposed to be essentially hormonal.
Abstract: Recently, the agricultural sector is facing concomitant challenges of rising the productivity to feed the growing global population and increasing the resources use efficiency, while reducing the environmental impact on the ecosystems and human health. In fact, fertilizers and pesticides play a crucial role in agriculture, representing a powerful tool for growers to increase yield and guarantee continuous productivity throughout the seasons under both optimal and suboptimal conditions. In the last three decades, several technological innovations have been proposed to enhance the sustainability of agricultural production systems, through a significant reduction of synthetic agrochemicals like pesticides and fertilizers. A promising and environmental-friendly innovation would be the use of natural plant biostimulants (PBs) that enhance flowering, plant growth, fruit set, crop productivity, and nutrient use efficiency (NUE), and are able also to improve the tolerance against a wide range of abiotic stressors (Colla and Rouphael, 2015). PBs were initially defined by excluding some functionalities like fertilizers or plant protection products. In 1997, in Grounds Maintenance web-journal, Zhang and Schmidt from the Department of Crop and Soil Environmental Sciences of the Virginia Polytechnic Institute and State University, defined PBs as “materials that, in minute quantities, promote plant growth”. By using the statement “minute quantities” for describing PBs, the authors implicitly wanted to discriminate biostimulants from nutrients and soil amendments, which also promote plant growth, but are clearly applied in larger quantities. The PBs mentioned in this web article were two important categories such as humic acids and seaweed extracts, and their action on plants was proposed to be essentially hormonal. In 2012, the European Commission has assigned an ad hoc study on plant biostimulants to evaluate the substances and materials involved, which was published by du Jardin (2012) as: “The Science of Plant Biostimulants A bibliographic Analysis”. Based on the scientific literature (250 scientific articles using the term ‘biostimulant' in their titles and/or abstracts), the following definition was proposed: “Plant biostimulants are substances and materials, with the exception of nutrients and pesticides, which, when applied to plant, seeds or growing substrates in specific formulations, have the capacity to modify physiological processes of plants in a way that provides potential benefits to growth, development and/or stress responses”. du Jardin (2012) concluded that PBs are very heterogeneous materials, and proposed in his study eight categories of substances that acts as biostimulants: humic substances, complex organic materials (obtained from agro-industrial and urban waste products, sewage sludge extracts, composts, and manure), beneficial chemical elements (Al, Co, Na, Se, and Si), inorganic salts including phosphite, seaweed extracts (brown, red, and green

300 citations


Authors

Showing all 29740 results

NameH-indexPapersCitations
D. M. Strom1763167194314
Yang Gao1682047146301
Robert Stone1601756167901
Elio Riboli1581136110499
Barry J. Maron15579291595
H. Eugene Stanley1541190122321
Paul Elliott153773103839
Robert O. Bonow149808114836
Kai Simons14742693178
Peter Buchholz143118192101
Martino Margoni1412059107829
H. A. Neal1411903115480
Luca Lista1402044110645
Pierluigi Paolucci1381965105050
Ari Helenius13729864789
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023234
2022660
20216,021
20205,957
20194,881
20184,267