scispace - formally typeset
Search or ask a question
Institution

University of Naples Federico II

EducationNaples, Campania, Italy
About: University of Naples Federico II is a education organization based out in Naples, Campania, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 29291 authors who have published 68803 publications receiving 1920149 citations. The organization is also known as: Università degli Studi di Napoli Federico II & Naples University.


Papers
More filters
Journal ArticleDOI
TL;DR: In this paper, the authors investigate whether information sharing among banks has affected credit market performance in the transition countries of Eastern Europe and the former Soviet Union, using a large sample of firm-level data.

285 citations

Journal ArticleDOI
TL;DR: The frequency of the hereditary forms of pheochromocytoma/paraganglioma varies depending on the family history and the clinical presentation, and which genes should be screened first is suggested.
Abstract: Purpose: The aim of the study was to define the frequency of hereditary forms and the genotype/phenotype correlations in a large cohort of Italian patients with pheochromocytomas and/or functional or nonfunctional paragangliomas. Design: We examined 501 consecutive patients with pheochromocytomas and/or paragangliomas (secreting or nonsecreting). Complete medical and family histories, as well as the results of clinical, laboratory, and imaging studies, were recorded in a database. Patients were divided into different groups according to their family history, the presence of lesions outside adrenals/paraganglia considered syndromic for VHL disease, MEN2, and NF1, and the number and types of pheochromocytomas and/or paragangliomas. Germ-line mutations in known susceptibility genes were investigated by gene sequencing (VHL, RET, SDHB, SDHC, SDHD) or diagnosed according to phenotype (NF1). In 160 patients younger than 50 yr with a wild-type profile, multiplex ligation-dependent probe amplification assays were...

285 citations

Journal ArticleDOI
TL;DR: Probiotic L rhamnosus strain GG warrants consideration as a therapeutic tool to treat hypertransaminasemia in hepatopathic obese children noncompliant with lifestyle interventions.
Abstract: Objective: Various lines of evidence suggest that malfunctioning of the gut–liver axis contributes to hepatic damage of rodents and humans with nonalcoholic fatty liver disease. We evaluated the effects of short-term probiotic treatment in children with obesity-related liver disease who were noncompliant with lifestyle interventions. Patients and Methods: Twenty obese children (age 10.7 � 2.1 years) with persisting hypertransaminasemia and ultrasonographic (US) bright liver were enrolled in this double-blind, placebo-controlled pilot study. At baseline, patients underwent clinical and laboratory anthropometric evaluation, measurement of the US hepatorenal ratio, standard liver function tests, oral glucose tolerance test, serum tumor necrosis factoralpha, the glucose hydrogen breath test, and evaluation of serum antibodies to antipeptidoglycan-polysaccharide polymers. After exclusion of causes of liver disease other than obesity, patients received either probiotic Lactobacillus rhamnosus strain GG (12 billion CFU/day) or placebo for 8 weeks. Results: Multivariate analysis after probiotic treatment revealed a significant decrease in alanine aminotransferase (average variation vs placebo P ¼ 0.03) and in antipeptidoglycan-polysaccharide antibodies (average variation vs placebo P ¼ 0.03) irrespective of changes in BMI z score and visceral fat. Tumor necrosis factor-alpha, and US bright liver parameters remained fairly stable. Conclusions: Probiotic L rhamnosus strain GG warrants consideration as a therapeutic tool to treat hypertransaminasemia in hepatopathic obese children noncompliant with lifestyle interventions.

285 citations

Journal ArticleDOI
TL;DR: Functionally impaired variants of COQ2 were associated with an increased risk of multiple-system atrophy in multiplex families and patients with sporadic disease, providing evidence of a role of impaired COQ1 activities in the pathogenesis of this disease.
Abstract: BACKGROUND Multiple-system atrophy is an intractable neurodegenerative disease characterized by autonomic failure in addition to various combinations of parkinsonism, cerebellar ataxia, and pyramidal dysfunction. Although multiple-system atrophy is widely considered to be a nongenetic disorder, we previously identified multiplex families with this disease, which indicates the involvement of genetic components. METHODS In combination with linkage analysis, we performed whole-genome sequencing of a sample obtained from a member of a multiplex family in whom multiple-system atrophy had been diagnosed on autopsy. We also performed mutational analysis of samples from members of five other multiplex families and from a Japanese series (363 patients and two sets of controls, one of 520 persons and one of 2383 persons), a European series (223 patients and 315 controls), and a North American series (172 patients and 294 controls). On the basis of these analyses, we used a yeast complementation assay and measured enzyme activity of parahydroxybenzoate-polyprenyl transferase. This enzyme is encoded by the gene COQ2 and is essential for the biosynthesis of coenzyme Q10. Levels of coenzyme Q10 in lymphoblastoid cells and brain tissue were measured on high-performance liquid chromatography. RESULTS We identified a homozygous mutation (M78V-V343A/M78V-V343A) and compound heterozygous mutations (R337X/V343A) in COQ2 in two multiplex families. Furthermore, we found that a common variant (V343A) and multiple rare variants in COQ2, all of which are functionally impaired, are associated with sporadic multiple-system atrophy. The V343A variant was exclusively observed in the Japanese population. CONCLUSIONS Functionally impaired variants of COQ2 were associated with an increased risk of multiple-system atrophy in multiplex families and patients with sporadic disease, providing evidence of a role of impaired COQ2 activities in the pathogenesis of this disease. (Funded by the Japan Society for the Promotion of Science and others.).

284 citations

Journal ArticleDOI
TL;DR: Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups, and asymptomatic patients with moderate and severe hypercholesterol have evidence of oxidant stress in vivo.
Abstract: Background—F2 isoprostanes are stable, free radical–catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results—Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF2α-III and iPF2α-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF2α-III (pmol/mmol creatinine) was elevated (P<0.0005) in homozygous familial hypercholesterolemic (HFH) patients (85±5.5; n=38) compared with age- and sex-matched normocholesterolemic control subjects (58±4.2; n=38), as were levels of iPF2α-VI (281±22 versus 175±13; P<0.0005). Serum cholesterol correlated with urinary iPF2α-III (r=0.41; P<0.02) and iPF2α-VI (r=0.39; P<0.03) in HFH patients. Urinary excretion of iPF2α-III (81±10 versus 59±4; P<0.05) and iPF2α-VI (195±18 versus 149±20; P<0.05) was also increased in moderately hypercholesterolemic subjects (n...

284 citations


Authors

Showing all 29740 results

NameH-indexPapersCitations
D. M. Strom1763167194314
Yang Gao1682047146301
Robert Stone1601756167901
Elio Riboli1581136110499
Barry J. Maron15579291595
H. Eugene Stanley1541190122321
Paul Elliott153773103839
Robert O. Bonow149808114836
Kai Simons14742693178
Peter Buchholz143118192101
Martino Margoni1412059107829
H. A. Neal1411903115480
Luca Lista1402044110645
Pierluigi Paolucci1381965105050
Ari Helenius13729864789
Network Information
Related Institutions (5)
University of Padua
114.8K papers, 3.6M citations

97% related

University of Bologna
115.1K papers, 3.4M citations

97% related

University of Florence
79.5K papers, 2.3M citations

97% related

Sapienza University of Rome
155.4K papers, 4.3M citations

96% related

University of Milan
139.7K papers, 4.6M citations

94% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023234
2022660
20216,021
20205,957
20194,881
20184,267