University of Naples Federico II

About: University of Naples Federico II is a education organization based out in Naples, Campania, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 29291 authors who have published 68803 publications receiving 1920149 citations. The organization is also known as: Università degli Studi di Napoli Federico II & Naples University.

The influence of codon context on genetic code translation

Abstract: A class of mutations that increase the deficiency of a suppressor tRNA in translating a particular amber codon has been characterized. The increased efficiency is due to a mutation resulting in a change in the mRNA that affects the nucleotide adjacent to the 3' side of the UAG triplet. Thus the interaction of tRNA with mRNA is influenced by mRNA sequences outside the triplet codon.

Ground deformation and gravity changes accompanying the 1982 Pozzuoli uplift

Abstract: During the summer of 1982 a continuous uplift began at Phlegraean Fields, an active volcanic area in southern Italy (Fig. 1), that persisted up to September 1984. The uplift, which reached a maximum value of about 160 cm in the central part of the Phlegraean caldera, was characterized by variable velocity and occurred within an area that extended about 7 km outward from the town of Pozzuoli (Fig. 1); the surface deformation performs a bell-shape pattern. The uplift was accompanied by horizontal displacements and gravity changes that closely correlate with the described elevation changes. The horizontal displacements displayed an anomalous pattern within a narrow belt about 1 km from the center of the uplift and approximately coincident with the area of maximum seismic activity. The change in gravity is attributed primarily to a free-air effect to which a small Bouguer effect must be added. Several models have been invoked in order to explain the observed phenomenon. The one which gives the best fit to the observed data is an increasing pressure source of radial simmetry, at a constant depth of about 3 km beneath the town of Pozzuoli, and having a diameter of several hundred meters. Migration of magma at depth is believed to be responsible for the observed activity in the Phlegraean Fields caldera.

The effect of cooking on the phytochemical content of vegetables

Abstract: Cooking induces many chemical and physical modifications in foods; among these the phytochemical content can change. Many authors have studied variations in vegetable nutrients after cooking, and great variability in the data has been reported. In this review more than 100 articles from indexed scientific journals were considered in order to assess the effect of cooking on different phytochemical classes. Changes in phytochemicals upon cooking may result from two opposite phenomena: (1) thermal degradation, which reduces their concentration, and (2) a matrix softening effect, which increases the extractability of phytochemicals, resulting in a higher concentration with respect to the raw material. The final effect of cooking on phytochemical concentration depends on the processing parameters, the structure of food matrix, and the chemical nature of the specific compound. Looking at the different cooking procedures it can be concluded that steaming will ensure better preservation/extraction yield of phenols and glucosinolates than do other cooking methods: steamed tissues are not in direct contact with the cooking material (water or oil) so leaching of soluble compounds into water is minimised and, at the same time, thermal degradation is limited. Carotenoids showed a different behaviour; a positive effect on extraction and the solubilisation of carotenes were reported after severe processing. © 2013 Society of Chemical Industry

Genetics, diagnosis and management of colorectal cancer (Review)

Abstract: Colorectal cancer (CRC) is the third most common type of cancer worldwide and a leading cause of cancer death. Surgery represents the mainstay of treatment in early cases but often patients are primarily diagnosed in an advanced stage of disease and sometimes also distant metastases are present. Neoadjuvant therapy is therefore needed but drug resistance may influence response and concur to recurrent disease. At molecular level, it is a very heterogeneous group of diseases with about 30% of hereditary or familial cases. During colorectal adenocarcinomas development, epithelial cells from gastrointestinal trait acquire sequential genetic and epigenetic mutations in specific oncogenes and/or tumour suppressor genes, causing CRC onset, progression and metastasis. Molecular characterization of cancer associated mutations gives valuable information about disease prognosis and response to the therapy. Very early diagnosis and personalised care, as well as a better knowledge of molecular basis of its onset and progression, are therefore crucial to obtain a cure of CRC. In this review, we describe updated genetics, current diagnosis and management of CRC pointing out the extreme need for a multidisciplinary approach to achieve the best results in patient outcomes.