Institution
University of Nebraska–Lincoln
Education•Lincoln, Nebraska, United States•
About: University of Nebraska–Lincoln is a education organization based out in Lincoln, Nebraska, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 28059 authors who have published 61544 publications receiving 2139104 citations. The organization is also known as: Nebraska & UNL.
Topics: Population, Poison control, Large Hadron Collider, Gene, Laser
Papers published on a yearly basis
Papers
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TL;DR: It is found that freestanding BiFeO3 films exhibit unexpected and giant tetragonality and polarization when approaching the 2D limit, and the absence of a critical thickness for stabilizing the crystalline order in thefreestanding ultrathin oxide films is demonstrated.
Abstract: Two-dimensional (2D) materials such as graphene and transition-metal dichalcogenides reveal the electronic phases that emerge when a bulk crystal is reduced to a monolayer1-4. Transition-metal oxide perovskites host a variety of correlated electronic phases5-12, so similar behaviour in monolayer materials based on transition-metal oxide perovskites would open the door to a rich spectrum of exotic 2D correlated phases that have not yet been explored. Here we report the fabrication of freestanding perovskite films with high crystalline quality almost down to a single unit cell. Using a recently developed method based on water-soluble Sr3Al2O6 as the sacrificial buffer layer13,14 we synthesize freestanding SrTiO3 and BiFeO3 ultrathin films by reactive molecular beam epitaxy and transfer them to diverse substrates, in particular crystalline silicon wafers and holey carbon films. We find that freestanding BiFeO3 films exhibit unexpected and giant tetragonality and polarization when approaching the 2D limit. Our results demonstrate the absence of a critical thickness for stabilizing the crystalline order in the freestanding ultrathin oxide films. The ability to synthesize and transfer crystalline freestanding perovskite films without any thickness limitation onto any desired substrate creates opportunities for research into 2D correlated phases and interfacial phenomena that have not previously been technically possible.
344 citations
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TL;DR: This paper found that the males in the sample played video games at twice the weekly average of females, were consistently stronger in all measured motives than the females, and preferred physically oriented video games over the females preference for more traditional, thoughtful games.
Abstract: Questionnaires were completed by 5th-, 8th-, and 11th-grade public schools students in rural and suburban school districts and by undergraduates at two universities in the United States (n = 1,242). They were asked about their orientation to video gamesâthe amount of time they played, their motives for doing so, and the game types they preferredâto better understand the context in which effects research might be organized. The conceptual schema for this research was the uses-and-gratifications perspective. The males in the sample played video games at twice the weekly average of the females, were consistently stronger in all measured motives than the females, and preferred physically oriented video games over the femalesâ preference for more traditional, thoughtful games. Younger players opted for the fantasy motive in their playing and older players more so for competition. Preference for physical games declined among the older males, and generally motives were stronger in the middle years of playing for both males and females than in the youngest and oldest age groups. Regression analyses explained considerably more variance in game playing for males than for females.
344 citations
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TL;DR: The outstanding efficacy and prolonged blood concentrations of OZ439 are the result of a design strategy that stabilizes the intrinsically unstable pharmacophoric peroxide bond, thereby reducing clearance yet maintaining the necessary Fe(II)-reactivity to elicit parasite death.
Abstract: Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase I clinical trials, where it was shown to be safe at doses up to 1,600 mg and is currently undergoing Phase IIa trials in malaria patients. Herein, we describe the discovery of OZ439 and the exceptional antimalarial and pharmacokinetic properties that led to its selection as a clinical drug development candidate. In vitro, OZ439 is fast-acting against all asexual erythrocytic Plasmodium falciparum stages with IC50 values comparable to those for the clinically used artemisinin derivatives. Unlike all other synthetic peroxides and semisynthetic artemisinin derivatives, OZ439 completely cures Plasmodium berghei-infected mice with a single oral dose of 20 mg/kg and exhibits prophylactic activity superior to that of the benchmark chemoprophylactic agent, mefloquine. Compared with other peroxide-containing antimalarial agents, such as the artemisinin derivatives and the first-generation ozonide OZ277, OZ439 exhibits a substantial increase in the pharmacokinetic half-life and blood concentration versus time profile in three preclinical species. The outstanding efficacy and prolonged blood concentrations of OZ439 are the result of a design strategy that stabilizes the intrinsically unstable pharmacophoric peroxide bond, thereby reducing clearance yet maintaining the necessary Fe(II)-reactivity to elicit parasite death.
344 citations
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TL;DR: Infection of swine with virulent porcine reproductive and respiratory syndrome (PRRS) virus induced a rapid, robust antibody response that comprised predominantly nonneutralizing antibodies and waned after approximately 3 months, whereas the initial onset of virus-specific interferon (IFN)-gamma-secreting cells in the pig lymphocyte population remained at a fairly low level during this period and then increased gradually in frequency.
344 citations
Authors
Showing all 28272 results
Name | H-index | Papers | Citations |
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Donald P. Schneider | 242 | 1622 | 263641 |
Suvadeep Bose | 154 | 960 | 129071 |
David D'Enterria | 150 | 1592 | 116210 |
Aaron Dominguez | 147 | 1968 | 113224 |
Gregory R Snow | 147 | 1704 | 115677 |
J. S. Keller | 144 | 981 | 98249 |
Andrew Askew | 140 | 1496 | 99635 |
Mitchell Wayne | 139 | 1810 | 108776 |
Kenneth Bloom | 138 | 1958 | 110129 |
P. de Barbaro | 137 | 1657 | 102360 |
Randy Ruchti | 137 | 1832 | 107846 |
Ia Iashvili | 135 | 1676 | 99461 |
Yuichi Kubota | 133 | 1695 | 98570 |
Ilya Kravchenko | 132 | 1366 | 93639 |
Andrea Perrotta | 131 | 1380 | 85669 |