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Institution

University of Nebraska–Lincoln

EducationLincoln, Nebraska, United States
About: University of Nebraska–Lincoln is a education organization based out in Lincoln, Nebraska, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 28059 authors who have published 61544 publications receiving 2139104 citations. The organization is also known as: Nebraska & UNL.


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Journal ArticleDOI
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Abstract: In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.

1,129 citations

Journal ArticleDOI
TL;DR: In this paper, a review of the development of ideas in the fields of geomorphology/Quaternary geology vs. sedimentary geologies is provided, and key processes that operate to produce alluvial stratigraphic records over time-scales of 103−106 years.
Abstract: Summary Fluvial landforms and deposits provide one of the most readily studied Quaternary continental records, and alluvial strata represent an important component in most ancient continental interior and continental margin successions. Moreover, studies of the long-term dynamics of fluvial systems and their responses to external or ‘allogenic' controls, can play important roles in research concerning both global change and sequence-stratigraphy, as well as in studies of the dynamic interactions between tectonic activity and surface processes. These themes were energized in the final decades of the twentieth century, and may become increasingly important in the first decades of this millennium. This review paper provides a historical perspective on the development of ideas in the fields of geomorphology/Quaternary geology vs. sedimentary geology, and then summarizes key processes that operate to produce alluvial stratigraphic records over time-scales of 103−106 years. Of particular interest are changes in discharge regimes, sediment supply and sediment storage en route from source terrains to sedimentary basins, as well as changes in sea-level and the concept of accommodation. Late Quaternary stratigraphic records from the Loire (France), Mississippi (USA), Colorado (Texas, USA) and Rhine–Meuse (The Netherlands) Rivers are used to illustrate the influences of climate change on continental interior rivers, as well as the influence of interacting climate and sea-level change on continental margin systems. The paper concludes with a look forward to a bright future for studies of fluvial response to climate and sea-level change. At present, empirical field-based research on fluvial response to climate and sea-level change lags behind: (a) the global change community's understanding of the magnitude and frequency of climate and sea-level change; (b) the sequence-stratigraphic community's desire to interpret climate and, especially, sea-level change as forcing mechanisms; and (c) the modelling community's ability to generate numerical and physical models of surface processes and their stratigraphic results. A major challenge for the future is to catch up, which will require the development of more detailed and sophisticated Quaternary stratigraphic, sedimentological and geochronological frameworks in a variety of continental interior and continental margin settings. There is a particular need for studies that seek to document fluvial responses to allogenic forcing over both shorter (102−103 years) and longer (104−106 years) time-scales than has commonly been the case to date, as well as in larger river systems, from source to sink. Studies of Quaternary systems in depositional basin settings are especially critical because they can provide realistic analogues for interpretation of the pre-Quaternary rock record.

1,125 citations

Journal ArticleDOI
TL;DR: In this paper, the authors investigated whether the recently emerging core construct of positive psychological capital (consisting of hope, resilience, optimism, and efficiency) plays a role in mediating the effect of supportive organizational climate with employee outcomes.
Abstract: Summary Although the value of a supportive organizational climate has been recognized over the years, there is a need for better understanding of its relationship with employee outcomes. This study investigates whether the recently emerging core construct of positive psychological capital (consistingofhope,resilience,optimism,andefficacy)playsaroleinmediatingtheeffectsofa supportive organizational climate with employee outcomes. Utilizing three diverse samples, results show that employees’ psychological capital is positively related to their performance, satisfaction, and commitment and a supportive climate is related to employees’ satisfaction and commitment. The study’s major hypothesis that employees’ psychological capital mediates the relationship between supportive climate and their performance was also supported. The implications of these findings conclude the article. Copyright # 2008 John Wiley & Sons, Ltd.

1,124 citations

Journal ArticleDOI
TL;DR: The importance of human knowledge, experiences, skills, and expertise has been investigated extensively by Harter,Schmidt, and Hayes (2002) and others and found to have a significant positive impact on performance outcomes.

1,123 citations

Journal ArticleDOI
TL;DR: The infrastructure that is being designed and constructed to support controlled experimentation with testing and regression testing techniques is described and the impact that this infrastructure has had and can be expected to have.
Abstract: Where the creation, understanding, and assessment of software testing and regression testing techniques are concerned, controlled experimentation is an indispensable research methodology. Obtaining the infrastructure necessary to support such experimentation, however, is difficult and expensive. As a result, progress in experimentation with testing techniques has been slow, and empirical data on the costs and effectiveness of techniques remains relatively scarce. To help address this problem, we have been designing and constructing infrastructure to support controlled experimentation with testing and regression testing techniques. This paper reports on the challenges faced by researchers experimenting with testing techniques, including those that inform the design of our infrastructure. The paper then describes the infrastructure that we are creating in response to these challenges, and that we are now making available to other researchers, and discusses the impact that this infrastructure has had and can be expected to have.

1,114 citations


Authors

Showing all 28272 results

NameH-indexPapersCitations
Donald P. Schneider2421622263641
Suvadeep Bose154960129071
David D'Enterria1501592116210
Aaron Dominguez1471968113224
Gregory R Snow1471704115677
J. S. Keller14498198249
Andrew Askew140149699635
Mitchell Wayne1391810108776
Kenneth Bloom1381958110129
P. de Barbaro1371657102360
Randy Ruchti1371832107846
Ia Iashvili135167699461
Yuichi Kubota133169598570
Ilya Kravchenko132136693639
Andrea Perrotta131138085669
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202393
2022381
20212,809
20202,977
20192,846
20182,854