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Institution

University of Nebraska–Lincoln

EducationLincoln, Nebraska, United States
About: University of Nebraska–Lincoln is a education organization based out in Lincoln, Nebraska, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 28059 authors who have published 61544 publications receiving 2139104 citations. The organization is also known as: Nebraska & UNL.


Papers
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Journal ArticleDOI
TL;DR: The authors' novel iron oxide MNP formulation did not cause long-term changes in the liver enzyme levels or induce oxidative stress and thus can be safely used for drug delivery and imaging applications.
Abstract: It is essential to determine the biodistribution, clearance, and biocompatibility of magnetic nanoparticles (MNPs) for in vivo biomedical applications to ensure their safe clinical use. We have studied these aspects with our novel iron oxide MNP formulation, which can be used as a magnetic resonance imaging (MRI) agent and a drug carrier system. Changes in serum and tissue iron levels were analyzed over 3 weeks after intravenous administration of MNPs to rats. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AKP) levels, and total iron-binding capacity (TIBC) were also measured with time to assess the effect of MNPs on liver function. Selected tissues were also analyzed for oxidative stress and studied histologically to determine biocompatibility of MNPs. Serum iron levels gradually increased for up to 1 week but levels slowly declined thereafter. Biodistribution of iron in various body tissues changed with time but greater fraction of the injected iron localized in the liver and spleen than in the brain, heart, kidney, and lung. Magnetization measurements of the liver and spleen samples showed a steady decrease over 3 weeks, suggesting particle degradation. Serum showed a transient increase in ALT, AST, AKP levels, and TIBC over a period of 6-24 h following MNP injection. The increase in oxidative stress was tissue dependent, reaching a peak at approximately 3 days and then slowly declining thereafter. Histological analyses of liver, spleen, and kidney samples collected at 1 and 7 days showed no apparent abnormal changes. In conclusion, our MNPs did not cause long-term changes in the liver enzyme levels or induce oxidative stress and thus can be safely used for drug delivery and imaging applications.

639 citations

Journal ArticleDOI
24 Apr 2014-Nature
TL;DR: Testing the hypothesis that herbaceous plant species losses caused by eutrophication may be offset by increased light availability due to herbivory demonstrates that nutrients and herbivores can serve as counteracting forces to control local plant diversity through light limitation, independent of site productivity, soil nitrogen, herbivore type and climate.
Abstract: Human alterations to nutrient cycles and herbivore communities are affecting global biodiversity dramatically. Ecological theory predicts these changes should be strongly counteractive: nutrient addition drives plant species loss through intensified competition for light, whereas herbivores prevent competitive exclusion by increasing ground-level light, particularly in productive systems. Here we use experimental data spanning a globally relevant range of conditions to test the hypothesis that herbaceous plant species losses caused by eutrophication may be offset by increased light availability due to herbivory. This experiment, replicated in 40 grasslands on 6 continents, demonstrates that nutrients and herbivores can serve as counteracting forces to control local plant diversity through light limitation, independent of site productivity, soil nitrogen, herbivore type and climate. Nutrient addition consistently reduced local diversity through light limitation, and herbivory rescued diversity at sites where it alleviated light limitation. Thus, species loss from anthropogenic eutrophication can be ameliorated in grasslands where herbivory increases ground-level light.

639 citations

Journal ArticleDOI
TL;DR: In this article, the authors sequenced 111 fragments from 102 genes in four soybean populations representing the populations before and after genetic bottlenecks and showed that soybean has lost many rare sequence variants and has undergone numerous allele frequency changes throughout its history.
Abstract: Soybean has undergone several genetic bottlenecks These include domestication in Asia to produce numerous Asian landraces, introduction of relatively few landraces to North America, and then selective breeding over the past 75 years It is presumed that these three human-mediated events have reduced genetic diversity We sequenced 111 fragments from 102 genes in four soybean populations representing the populations before and after genetic bottlenecks We show that soybean has lost many rare sequence variants and has undergone numerous allele frequency changes throughout its history Although soybean genetic diversity has been eroded by human selection after domestication, it is notable that modern cultivars have retained 72% of the sequence diversity present in the Asian landraces but lost 79% of rare alleles (frequency ≤010) found in the Asian landraces Simulations indicated that the diversity lost through the genetic bottlenecks of introduction and plant breeding was mostly due to the small number of Asian introductions and not the artificial selection subsequently imposed by selective breeding The bottleneck with the most impact was domestication; when the low sequence diversity present in the wild species was halved, 81% of the rare alleles were lost, and 60% of the genes exhibited evidence of significant allele frequency changes

639 citations

Journal ArticleDOI
01 Apr 2003
TL;DR: Gaining customer trust in m-commerce is a daunting process, extending from initial trust formation to continuous trust development---but it can be done.
Abstract: Gaining customer trust in m-commerce is a daunting process, extending from initial trust formation to continuous trust development---but it can be done.

638 citations


Authors

Showing all 28272 results

NameH-indexPapersCitations
Donald P. Schneider2421622263641
Suvadeep Bose154960129071
David D'Enterria1501592116210
Aaron Dominguez1471968113224
Gregory R Snow1471704115677
J. S. Keller14498198249
Andrew Askew140149699635
Mitchell Wayne1391810108776
Kenneth Bloom1381958110129
P. de Barbaro1371657102360
Randy Ruchti1371832107846
Ia Iashvili135167699461
Yuichi Kubota133169598570
Ilya Kravchenko132136693639
Andrea Perrotta131138085669
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202393
2022381
20212,809
20202,977
20192,846
20182,854