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Institution

University of Nebraska Omaha

EducationOmaha, Nebraska, United States
About: University of Nebraska Omaha is a education organization based out in Omaha, Nebraska, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 4526 authors who have published 8905 publications receiving 213914 citations. The organization is also known as: UNO & University of Omaha.


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Journal ArticleDOI
TL;DR: The results provide data to help define standards for training and credentialing and suggest that general internists' training in procedural skills should be reexamine.
Abstract: Study objective To determine which of 40 clinical procedures general internists do in their practice, how often these procedures are done, and what training is needed to develop and maintain competence in each. Design Mailed survey. Participants A random sample of 2500 American College of Physicians (ACP) members identified as general internists; 1806 (72%) responded. Of these, we excluded 398 who were board eligible or board certified in a subspecialty and 143 with unknown status. The resulting sample of 1179 was augmented in selected analyses by an additional sample of 199 rural internists. Results General internists did, on average, 16 of the 40 procedures. Practice characteristics markedly affected the number and variety of procedures done. A larger number of different procedures was independently associated with smaller cities, smaller hospitals, younger age, increased hours in patient care, and certain regions of the country. Practice characteristics varied considerably by practice type and location. Many procedures were done infrequently. There was reasonable agreement on the experience needed to attain and maintain competency in each procedure. The majority of respondents favored hospital credentialing for 22 of the 40 procedures. Conclusions General internists do a wide variety of procedures, the number and frequency of which are affected by the characteristics and location of their practice. Despite opinion to the contrary, more recently trained general internists do a wider variety of procedures than older colleagues. These results provide data to help define standards for training and credentialing and suggest that we should reexamine general internists' training in procedural skills.

83 citations

Proceedings ArticleDOI
28 Dec 2009
TL;DR: This paper is aimed at reporting which existing methods have been found effective by others, as well as documenting the findings of the authors' own experiments, which will assist in the progression towards a safe, unobtrusive monitoring system for independent seniors.
Abstract: As we grow old, our desire for independence does not diminish; yet our health increasingly needs to be monitored. Injuries such as falling can be a serious problem for the elderly. If a person falls and is not able to get assistance within an hour, casualties arising from that fall can result in fatalities as early as 6 months later [1]. It would seem then that a choice between safety and independence must be made. Fortunately, as health care technology advances, simple devices can be made to detect or even predict falls in the elderly, which could easily save lives without too much intrusion on their independence. Much research has been done on the topic of fall detection and fall prediction. Some have attempted to detect falls using a variety of sensors such as: cameras, accelerometers, gyroscopes, microphones, or a combination of the like. This paper is aimed at reporting which existing methods have been found effective by others, as well as documenting the findings of our own experiments. The combination of which will assist in the progression towards a safe, unobtrusive monitoring system for independent seniors.

82 citations

Journal ArticleDOI
TL;DR: The results demonstrated that as the level of difficulty in the postural task increased, there was a significant reduction in verbal response time from congruent to incongruent conditions in the auditory Stroop task, but no differences in gait parameters, indicating that these postural tasks require attention.
Abstract: Research on attention and gait stability has suggested that the process of recovering gait stability requires attentional resources, but the effect of performing a secondary task on stability during obstacle avoidance is poorly understood. Using a dual-task paradigm, the present experiment investigated the extent to which young adults are able to respond to a secondary auditory Stroop task (requiring executive attentional network resources) concurrently with obstacle crossing during gait when compared with performing unobstructed walking or sitting (control task). Our results demonstrated that as the level of difficulty in the postural task increased, there was a significant reduction in verbal response time from congruent to incongruent conditions in the auditory Stroop task, but no differences in gait parameters, indicating that these postural tasks require attention, and that young adults use a strategy of modulating the auditory Stroop task performance while keeping stable gait performance under the dual-task situations. Our findings suggest the existence of a hierarchy of control within both postural task (obstacle avoidance requires the most information processing resources) and dual-task (with gait stability being a priority) conditions.

82 citations

Journal ArticleDOI
TL;DR: The docking data show that the induced-fit docking (IFD) protocol can successfully reproduce the native poses of ligands from different sources and indicate that imatinib is a weak binder to the active state of ABL but a strong binderto EGFR.
Abstract: Inhibition of tyrosine kinases (such as the epidermal growth factor receptor, EGFR, and/or Abelson leukemia virus protein kinase, ABL) represents a major advancement in the treatment of solid tumors, supported by the clinical administration of gefitinib, erlotinib, imatinib, and dasatinib. The identification of the binding interactions in the EGFR/ligands and the ABL/ligands complexes can facilitate the structure-based design of new tyrosine kinase inhibitors. We carried out induced-fit docking studies of 18 structurally diverse kinase inhibitors against the EGFR, the active and inactive states of the ABL protein. Our docking data show that the induced-fit docking (IFD) protocol can successfully reproduce the native poses of ligands from different sources. The binding interactions and the docked poses are consistent with the available experimental data. Our results indicate that imatinib is a weak binder to the active state of ABL but a strong binder to EGFR. The increased sensitivity of erlotinib to EGFR might be attributed to Cys797 of EGFR. In addition to Cys797, other important residues for kinase inhibitor design include Thr790, Met793, Lys745 and Asp855 of EGFR; and Thr315, Met318, Asp381 and Glu286 of the ABL. The minimum number of H-bonds required for the ligand binding provides a reasonable explanation to the effectiveness of nilotinib against most imatinib resistant mutants.

82 citations

Journal ArticleDOI
TL;DR: Findings suggest that the inhibitory influences of FLX on male rat copulatory behavior are mediated in part by the interaction ofFLX with neurons originating in the PGi.
Abstract: In Experiment 1, the 5-HT uptake blocker fluoxetine (FLX; 20 mg/kg) reduced the proportion of sexually experienced male rats displaying ejaculations. Among those animals that did ejaculate there was an increase in intromission frequency (IF), ejaculation latency (EL), and postejaculatory interval (PEI) and a reduction in copulatory efficiency (CE) during the final copulatory sequence prior to sexual exhaustion. In Experiment 2, we found similar inhibitory effects of FLX as well as facilitating effects of lesions of the nucleus paragigantocellularis (PGi) on male rat copulatory behavior. Males with PGi lesions displayed more ejaculations and a longer latency to sexual exhaustion compared to intact animals. When FLX was given to rats with PGi lesions, it did not influence the proportion of rats ejaculating nor did it alter IF, EL, or PEI during the final copulatory series prior to exhaustion. These findings suggest that the inhibitory influences of FLX on male rat copulatory behavior are mediated in part by the interaction of FLX with neurons originating in the PGi.

82 citations


Authors

Showing all 4588 results

NameH-indexPapersCitations
Darell D. Bigner13081990558
Dan L. Longo12569756085
William B. Dobyns10543038956
Eamonn Martin Quigley10368539585
Howard E. Gendelman10156739460
Alexander V. Kabanov9944734519
Douglas T. Fearon9427835140
Dapeng Yu9474533613
John E. Wagner9448835586
Zbigniew K. Wszolek9357639943
Surinder K. Batra8756430653
Frank L. Graham8525539619
Jing Zhou8453337101
Manish Sharma82140733361
Peter F. Wright7725221498
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202323
2022108
2021585
2020537
2019492
2018421