Institution
University of Nebraska Omaha
Education•Omaha, Nebraska, United States•
About: University of Nebraska Omaha is a education organization based out in Omaha, Nebraska, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 4526 authors who have published 8905 publications receiving 213914 citations. The organization is also known as: UNO & University of Omaha.
Papers published on a yearly basis
Papers
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TL;DR: It is suggested that Zn 2+ plays a significant structural role in addition to its catalytic role in Zn2+-protease activity of type A botulinum neurotoxin.
Abstract: Zn2+-protease activity of botulinum neurotoxin causes the blockage of neurotransmitter release resulting in botulism disease. We have investigated the role of Zn2+ in the biological activity of type A botulinum neurotoxin by removing the bound Zn2+ by EDTA treatment, followed by monitoring its structure in terms of secondary and tertiary folding (second derivative UV, FT-IR, and circular dichroism spectroscopy) and function in terms of its effect on the release of norepinephrine from PC12 cells. The single Zn2+ bound to each neurotoxin molecule was reversibly removed by EDTA treatment, whereas the biological activity of the neurotoxin was irreversibly lost. Based on the Amide III IR spectral analysis, the α-helical content of neurotoxin increased from 29% to 42% upon removal of Zn2+, which reverted to 31% upon treatment with 1:5 molar excess of exogenous Zn2+. Second derivative UV spectroscopy revealed no change in surface topography of Tyr residues with removal of Zn2+. However, near-UV circular dichrois...
59 citations
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TL;DR: A unified CAF classification based on specific functions to develop a new class of therapies that will focus on targeting the pro-tumorigenic properties of CAFs during tumor progression and address the remarkable degree of functional diversity and phenotypic plasticity displayed by CAFs.
Abstract: Cancer-associated fibroblasts (CAFs) are indispensable architects of the tumor microenvironment. They perform the essential functions of extracellular matrix deposition, stromal remodeling, tumor vasculature modulation, modification of tumor metabolism, and participation in crosstalk between cancer and immune cells. In this review, we discuss our current understanding of the principal differences between normal fibroblasts and CAFs, the origin of CAFs, their functions, and ultimately, highlight the intimate connection of CAFs to virtually all of the hallmarks of cancer. We address the remarkable degree of functional diversity and phenotypic plasticity displayed by CAFs and strive to stratify CAF biology among different tumor types into practical functional groups. Finally, we summarize the status of recent and ongoing trials of CAF-directed therapies and contend that the paucity of trials resulting in Food and Drug Administration (FDA) approvals thus far is a consequence of the failure to identify targets exclusive of pro-tumorigenic CAF phenotypes that are mechanistically linked to specific CAF functions. We believe that the development of a unified CAF nomenclature, the standardization of functional assays to assess the loss-of-function of CAF properties, and the establishment of rigorous definitions of CAF subpopulations and their mechanistic functions in cancer progression will be crucial to fully realize the promise of CAF-targeted therapies.
59 citations
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TL;DR: The structure of the general classical trajectory FORTRAN code is discussed for use in molecular dynamics simulations of polymer processes by using statement functions, modifying the ususal chain rule derivatives, and applying appropriate vector identities.
Abstract: The structure of the general classical trajectory FORTRAN code is discussed for use in molecular dynamics simulations of polymer processes. Substantial reductions in the number of mathematical operations in the code are achieved by using statement functions, modifying the ususal chain rule derivatives, applying appropriate vector identities, and using closure relationships among the required derivatives of the potential.
59 citations
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TL;DR: The results suggest that the OT system is highly involved in reducing fidelity-threatening behaviors in well-established marmoset pairs, and that the effects were only produced by species-specific OT ligands.
59 citations
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TL;DR: Religiosity seems to moderate death anxiety, but not in all groups as discussed by the authors, and the two constructs apparently are related mostly among those who are high in intrinsic religiosity or low in death anxiety.
Abstract: Religiosity seems to moderate death anxiety, but not in all groups. The two constructs apparently are related mostly among those who are high in intrinsic religiosity or low in death anxiety, or bo...
59 citations
Authors
Showing all 4588 results
Name | H-index | Papers | Citations |
---|---|---|---|
Darell D. Bigner | 130 | 819 | 90558 |
Dan L. Longo | 125 | 697 | 56085 |
William B. Dobyns | 105 | 430 | 38956 |
Eamonn Martin Quigley | 103 | 685 | 39585 |
Howard E. Gendelman | 101 | 567 | 39460 |
Alexander V. Kabanov | 99 | 447 | 34519 |
Douglas T. Fearon | 94 | 278 | 35140 |
Dapeng Yu | 94 | 745 | 33613 |
John E. Wagner | 94 | 488 | 35586 |
Zbigniew K. Wszolek | 93 | 576 | 39943 |
Surinder K. Batra | 87 | 564 | 30653 |
Frank L. Graham | 85 | 255 | 39619 |
Jing Zhou | 84 | 533 | 37101 |
Manish Sharma | 82 | 1407 | 33361 |
Peter F. Wright | 77 | 252 | 21498 |