University of Nebraska Omaha

About: University of Nebraska Omaha is a education organization based out in Omaha, Nebraska, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 4526 authors who have published 8905 publications receiving 213914 citations. The organization is also known as: UNO & University of Omaha.

Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumors

Abstract: Ovarian cancer is a complicated malady associated with cancer stem cells (CSCs) contributing to 238,700 estimated new cases and 151,900 deaths per year, worldwide. CSCs comprise a tiny fraction of tumor-bulk responsible for cancer recurrence and eventual mortality. CSCs or tumor initiating cells are responsible for self-renewal, differentiation and proliferative potential, tumor initiation capability, its progression, drug resistance and metastatic spread. Although several biomarkers are implicated in these processes, their distribution within the ovary and association with single cell type has neither been established nor demonstrated across ovarian tumor developmental stages. Therefore, precise identification, thorough characterization and effective targeted destruction of dormant and highly proliferating potent CSC populations is an immediate need. In view of this, distribution of various CSC (ALDH1/2, C-KIT, CD133, CD24 and CD44) and cell proliferation (KI67) specific markers in the ovarian surface epithelium (OSE) and cortex regions in normal ovary, and benign, borderline and high grade metastatic ovarian tumors by immuno-histochemistry and confocal microscopy was studied. We further confirmed their expression by RT-PCR analysis. Co-expression analysis of stem cell (OCT4, SSEA4) and CSC (ALDH1/2, CD44 and LGR5) markers with proliferation marker (KI67) in HG tumors revealed dual positive proliferating stem and CSCs, few non-proliferating stem/CSC (SSEA4+/KI67− and ALDH1/2+/KI67−) and only KI67+ cells in cortex, signifying dynamic populations and interesting cellular hierarchy in cortex region. Smaller spherical (≤ 5 μm) and larger spindle/elliptical shaped (~ 10 μm) cell populations with high nucleo-cytoplasmic ratio were detected across all samples (including normal ovaries) but with variable distribution and characteristic stage-wise marker expression across different tumor stages. Diverse stem and CSC populations expressing characteristic markers revealing distinct phenotypes (spherical ≤5 μm and spindle/elliptical ~ 10 μm) were distributed within different tumor stages studied signifying dynamic and probable functional hierarchy within these cell types. Involvement of extra-ovarian sites of origin of stem and CSCs requires rigorous evaluation. Quantitative analysis of potent CSC populations, their mechanisms and pathways for self-renewal, chemo-resistance, metastatic spread etc. with respect to various markers studied, will provide better insights and targets for developing effective therapeutics to prevent metastasis and eventually help improve patient mortality.

Sex Offender Community Notification Laws: Are Their Effects Symbolic or Instrumental in Nature?:

Abstract: Researchers interested in public policy have noted that laws may have a symbolic or an instrumental function. The example of sex offender legislation is used to look for both instrumental and symbolic effects of this legislation. Although the symbolic effects of sex offender legislation have been examined by prior research, less is known about the instrumental effects of this legislation. This research examines the instrumental functions of sex offender legislation using survey data that asked about whether members of the public have checked the sex offender registry and the reasons behind their answer. The findings of this study suggest largely symbolic effects of sex offender registry legislation, and implications of this finding are discussed.

The Effect of Race and Gender on Bail Outcomes: A Test of an Interactive Model

Abstract: This paper responds to suggestions that researchers interested in the relationship between defendant race, defendant gender, and criminal justice outcomes broaden their focus to include pretrial decision making. We used data on defendants charged with violent felonies in Detroit Recorder’s Court to analyze the effect of race and gender on the amount of bail imposed by the judge and on the defendant’s pretrial status. We found that judges take gender, but not race, into account in determining the amount of bail for certain types of cases; more specifically, Black females faced lower bail than Black males in less serious cases. In contrast, we found that both race and gender affected the likelihood of pretrial release. White defendants were more likely than black defendants to be released pending trial and females were more likely than males to be released prior to trial. In fact, white females, white males, and black females all were more likely than black males to be released.

Personality and the Preference for Modes of Conflict Resolution

Abstract: This article reports the research findings of the relationships of personality variables and preferences for modes of conflict resolution. Eleven hypotheses were developed relating nine personality variables-achievement, dominance, aggression, affiliation, deference, succorance, nurturance, dogmatism, and Machiavellianism-to the preference for smoothing, forcing and confronting. These hypotheses were tested using a sample of 136 MBA students and support was found for eight hypotheses. As hypothesized positive correlations were found between the following variables: affiliation-smoothing, deference-forcing, succorance-smoothing, nurturance-smoothing, dogmatism-confronting, and Machiavellianism-confronting. Support was also found for two hypothesized negative correlations: affiliation-forcing and Machiavellianism-smoothing. No support was found for the hypotheses relating achievement to confronting, dominance to forcing, and aggression to forcing.