Institution
University of Nebraska Omaha
Education•Omaha, Nebraska, United States•
About: University of Nebraska Omaha is a education organization based out in Omaha, Nebraska, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 4526 authors who have published 8905 publications receiving 213914 citations. The organization is also known as: UNO & University of Omaha.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Evidence supports the presence of an optimal state of variability for healthy and functional movement, and innovations in the exploration of variability and their potential importance in understanding human movement are described.
774 citations
••
University of Rochester1, Stanford University2, Cleveland Clinic3, Mayo Clinic4, University of Nebraska Omaha5, Harvard University6, University of California, Los Angeles7, Emory University8, Cornell University9, Indiana University – Purdue University Indianapolis10, Rush University Medical Center11
TL;DR: Disrupting BCR-induced signaling by inhibiting Syk represents a novel and active therapeutic approach for NHL and SLL/CLL.
760 citations
••
George Washington University1, University of Oklahoma2, University of Kansas3, International Union for Conservation of Nature and Natural Resources4, University of Alaska Fairbanks5, Shanghai Ocean University6, Johnson County Community College7, Old Dominion University8, University of Nebraska–Lincoln9, Loyola University Chicago10, University of Nebraska Omaha11, Florida A&M University12
TL;DR: A comprehensive molecular phylogeny for bony fishes that includes representatives of all major lineages and the order Perciformes, considered by many a polyphyletic taxonomic waste basket, is defined for the first time as a monophyletic group in the global phylogeny.
Abstract: The tree of life of fishes is in a state of flux because we still lack a comprehensive phylogeny that includes all major groups. The situation is most critical for a large clade of spiny-finned fishes, traditionally referred to as percomorphs, whose uncertain relationships have plagued ichthyologists for over a century. Most of what we know about the higher-level relationships among fish lineages has been based on morphology, but rapid influx of molecular studies is changing many established systematic concepts. We report a comprehensive molecular phylogeny for bony fishes that includes representatives of all major lineages. DNA sequence data for 21 molecular markers (one mitochondrial and 20 nuclear genes) were collected for 1410 bony fish taxa, plus four tetrapod species and two chondrichthyan outgroups (total 1416 terminals). Bony fish diversity is represented by 1093 genera, 369 families, and all traditionally recognized orders. The maximum likelihood tree provides unprecedented resolution and high bootstrap support for most backbone nodes, defining for the first time a global phylogeny of fishes. The general structure of the tree is in agreement with expectations from previous morphological and molecular studies, but significant new clades arise. Most interestingly, the high degree of uncertainty among percomorphs is now resolved into nine well-supported supraordinal groups. The order Perciformes, considered by many a polyphyletic taxonomic waste basket, is defined for the first time as a monophyletic group in the global phylogeny. A new classification that reflects our phylogenetic hypothesis is proposed to facilitate communication about the newly found structure of the tree of life of fishes. Finally, the molecular phylogeny is calibrated using 60 fossil constraints to produce a comprehensive time tree. The new time-calibrated phylogeny will provide the basis for and stimulate new comparative studies to better understand the evolution of the amazing diversity of fishes.
740 citations
••
Wellcome Trust Sanger Institute1, Ludwig Maximilian University of Munich2, Max Planck Society3, Cambridge University Hospitals NHS Foundation Trust4, University of Würzburg5, University of Pavia6, International Agency for Research on Cancer7, Istituto Giannina Gaslini8, University of Nebraska Omaha9, University College London10, University of Oxford11, University of Paris12, University of Nebraska–Lincoln13
TL;DR: A gene, SH2D1A, is identified that is mutated in XLP patients and encodes a novel protein composed of a single SH2 domain that is expressed in many tissues involved in the immune system.
Abstract: X-linked lymphoproliferative syndrome (XLP or Duncan disease) is characterized by extreme sensitivity to Epstein-Barr virus (EBV), resulting in a complex phenotype manifested by severe or fatal infectious mononucleosis, acquired hypogammaglobulinemia and malignant lymphoma. We have identified a gene, SH2D1A, that is mutated in XLP patients and encodes a novel protein composed of a single SH2 domain. SH2D1A is expressed in many tissues involved in the immune system. The identification of SH2D1A will allow the determination of its mechanism of action as a possible regulator of the EBV-induced immune response.
737 citations
Authors
Showing all 4588 results
Name | H-index | Papers | Citations |
---|---|---|---|
Darell D. Bigner | 130 | 819 | 90558 |
Dan L. Longo | 125 | 697 | 56085 |
William B. Dobyns | 105 | 430 | 38956 |
Eamonn Martin Quigley | 103 | 685 | 39585 |
Howard E. Gendelman | 101 | 567 | 39460 |
Alexander V. Kabanov | 99 | 447 | 34519 |
Douglas T. Fearon | 94 | 278 | 35140 |
Dapeng Yu | 94 | 745 | 33613 |
John E. Wagner | 94 | 488 | 35586 |
Zbigniew K. Wszolek | 93 | 576 | 39943 |
Surinder K. Batra | 87 | 564 | 30653 |
Frank L. Graham | 85 | 255 | 39619 |
Jing Zhou | 84 | 533 | 37101 |
Manish Sharma | 82 | 1407 | 33361 |
Peter F. Wright | 77 | 252 | 21498 |