University of Nevada, Reno

About: University of Nevada, Reno is a education organization based out in Reno, Nevada, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 13561 authors who have published 28217 publications receiving 882002 citations. The organization is also known as: University of Nevada & Nevada State University.

Venous Thrombosis and Conjugated Equine Estrogen in Women Without a Uterus

Abstract: Background: Postmenopausal hormone therapy has been associated with a 2- to 3-fold increased risk of venous thromboembolism (VT) (including deep vein thrombosis and pulmonary embolism) in observational studies and secondary prevention clinical trials. Clinical trial data on the effects of estrogen alone on VT are limited. Methods: The Women’s Health Initiative estrogen trial enrolled 10 739 women aged 50 to 79 years without a uterus. Participants were randomly assigned to receive conjugated equine estrogen (0.625 mg/d) or placebo. Results: During a mean of 7.1 years, VT occurred in 111 women randomly assigned to receive estrogen (3.0 per 1000 person-years) and 86 randomly assigned to receive placebo (2.2 per 1000 person-years; hazard ratio, 1.32; 95% confidence interval, 0.99-1.75). Deep venous thrombosis was reported in 85 women randomly assigned to receive estrogen (2.3 per 1000 person-years) and 59 randomly assigned to receive placebo (1.5 per 1000 person-years; hazard ratio, 1.47; 95% confidence interval, 1.06-2.06). The VT risk was highest in the first 2 years. There were no significant interactions between estrogen use and age, body mass index, or most other VT risk factors. Comparison of Women’s Health Initiative VT findings for estrogen and previous Women’s Health Initiative findings for estrogen plus progestin showed that the hazard ratios for estrogen plus progestin were significantly higher than those for estrogen alone (P=.03), even after adjusting for VT risk factors. Conclusion: An early increased VT risk is associated with use of estrogen, especially within the first 2 years, but this risk increase is less than that for estrogen plus progestin. Arch Intern Med. 2006;166:772-780

The Impact of CBT and ACT Models Using Psychology Trainee Therapists A Preliminary Controlled Effectiveness Trial

Abstract: The present study compares the impact of individualized treatment provided by trainee therapists based on a traditional cognitive behavior therapy (CBT) and acceptance and commitment therapy (ACT) model. Fourteen therapists were given initial training in CBT and ACT. Outpatients (N = 28) were randomized to either approach, with each therapist treating one client within each model, linked to a functional analysis. Clients treated within an ACT model showed better symptom improvement than the CBT clients, despite the fact that students felt initially less knowledgeable about ACT and were more fearful throughout when it was used. CBT improved client self-confidence more rapidly than ACT, and ACT improved acceptance more than CBT. Both processes predicted better outcomes; acceptance remained predictive when controlling for self-confidence but not vice versa. Overall, therapists with limited training in both models got better results with ACT and the processes of change fit with the ACT model.

Interstitial cells of Cajal: primary targets of enteric motor innervation.

Abstract: For many years morphologists have noted the close relationship between interstitial cells of Cajal (ICC) and nerve fibers within the tunica muscularis of gastrointestinal (GI) organs. These observations led to speculations about a role for ICC in mediating neural inputs to the GI tract. Immunohistochemical and functional studies demonstrated the presence of receptors for the neurotransmitters utilized by enteric motor neurons, and changes in second messengers in ICC after field stimulation of intrinsic enteric neurons showed that ICC were functionally innervated in GI muscles. Recent double labeling experiments have shown that both excitatory and inhibitory enteric motor neurons are closely associated with ICC in the deep muscular plexus (IC-DMP) of the small intestine and intramuscular ICC (IC-IM) of the proximal and distal GI tract. Enteric motor neurons form synaptic-like structures with IC-IM and IC-DMP. Far fewer close contacts are found between enteric motor neurons and smooth muscle cells. Experiments on W/W(V) mutants that lack IC-IM in the stomach, lower esophageal sphincter, and pylorus have shown that these ICC are critical components of the neuromuscular junction. Cholinergic excitatory and nitrergic inhibitory neurotransmission are severely decreased in tissues lacking IC-IM, yet there is no loss of cholinergic or nitrergic neurons in W/W(V) mutants. These data suggest that either the post-junctional mechanisms responsible for receiving and transducing neurotransmitter signals are specifically expressed by ICC, or that the large extracellular spaces typically between nerve terminals and smooth muscle cells may not allow effective concentrations of neurotransmitters to reach receptors expressed by smooth muscle cells. These findings indicate an important role for certain classes of ICC in enteric neurotransmission and predict that loss of ICC in human motor disturbances may significantly compromise neural regulation of GI motility.

Mineralogy of Juventae Chasma: Sulfates in the light-toned mounds, mafic minerals in the bedrock, and hydrated silica and hydroxylated ferric sulfate on the plateau

Abstract: [1] Juventae Chasma contains four light-toned sulfate-bearing mounds (denoted here as A–D from west to east) inside the trough, mafic outcrops at the base of the mounds and in the wall rock, and light-toned layered deposits of opal and ferric sulfates on the plateau. Hyperspectral visible/near-infrared Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) spectra were used to identify monohydrated and polyhydrated sulfate (PHS) outcrops of layered material on the bright mounds. Most of the monohydrated sulfate signatures closely resemble those of szomolnokite (FeSO4·H2O), characterized by a water band near 2.08 μm, while some areas exhibit spectral features more similar to those of kieserite (MgSO4·H2O), with a band centered closer to 2.13 μm. The largest PHS outcrops occur on the top of mound B, and their spectral features are most consistent with ferricopiapite, melanterite, and starkeyite, but a specific mineral cannot be uniquely identified at this time. Coordinated analyses of CRISM maps, Mars Orbiter Laser Altimeter elevations, and High Resolution Imaging Science Experiment images suggest that mounds A and B may have formed together and then eroded into separate mounds, while mounds C and D likely formed separately. Mafic minerals (low-Ca pyroxene, high-Ca pyroxene, and olivine) are observed in large ∼2–10 km wide outcrops in the wall rock and in smaller outcrops ∼50–500 m across at the floor of the canyon. Most of the wall rock is covered by at least a thin layer of dust and does not exhibit strong features characteristic of these minerals. The plateau region northwest of Juventae Chasma is characterized by an abundance of light-toned layered deposits. One region contains two spectrally unique phases exhibiting a highly stratified, terraced pattern. CRISM spectra of one unit eroded into swirling patterns with arc-like ridges exhibit a narrow 2.23-μm band assigned to hydroxylated ferric sulfate. A thin layer of a fractured material bearing an opaline silica phase is observed at the contact between the older plateau unit and the younger hydroxylated ferric sulfate-bearing light-toned layered deposits. Hydrothermal processes may have produced an acidic environment that fostered formation of the hydrated silica and hydroxylated ferric sulfate units.