University of New Haven

About: University of New Haven is a education organization based out in West Haven, Connecticut, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 836 authors who have published 1728 publications receiving 32329 citations. The organization is also known as: UNH.

Estimating 3-D rigid body transformations: a comparison of four major algorithms

Abstract: A common need in machine vision is to compute the 3-D rigid body transformation that aligns two sets of points for which correspondence is known. A comparative analysis is presented here of four popular and efficient algorithms, each of which computes the translational and rotational components of the transform in closed form, as the solution to a least squares formulation of the problem. They differ in terms of the transformation representation used and the mathematical derivation of the solution, using respectively singular value decomposition or eigensystem computation based on the standard $[ \vec{R}, \vec{T} ]$ representation, and the eigensystem analysis of matrices derived from unit and dual quaternion forms of the transform. This comparison presents both qualitative and quantitative results of several experiments designed to determine (1) the accuracy and robustness of each algorithm in the presence of different levels of noise, (2) the stability with respect to degenerate data sets, and (3) relative computation time of each approach under different conditions. The results indicate that under “ideal” data conditions (no noise) certain distinctions in accuracy and stability can be seen. But for “typical, real-world” noise levels, there is no difference in the robustness of the final solutions (contrary to certain previously published results). Efficiency, in terms of execution time, is found to be highly dependent on the computer system setup.

Assay-Dependent Phytotoxicity of Nanoparticles to Plants

Abstract: The effects of five nanomaterials (multiwalled carbon nanotubes [MWCNTs], Ag, Cu, ZnO, Si) and their corresponding bulk counterparts on seed germination, root elongation, and biomass of Cucurbita pepo (zucchini) were investigated. The plants were grown in hydroponic solutions amended with nanoparticles or bulk material suspensions at 1000 mg/L. Seed germination was unaffected by any of the treatments, but Cu nanoparticles reduced emerging root length by 77% and 64% relative to unamended controls and seeds exposed to bulk Cu powder, respectively. During a 15-day hydroponic trial, the biomass of plants exposed to MWCNTs and Ag nanoparticles was reduced by 60% and 75%, respectively, as compared to control plants and corresponding bulk carbon and Ag powder solutions. Although bulk Cu powder reduced biomass by 69%, Cu nanoparticle exposure resulted in 90% reduction relative to control plants. Both Ag and Cu ion controls (1−1000 mg/L) and supernatant from centrifuged nanoparticle solutions (1000 mg/L) indicate ...

Genetic compensation triggered by mutant mRNA degradation

Abstract: Genetic robustness, or the ability of an organism to maintain fitness in the presence of harmful mutations, can be achieved via protein feedback loops. Previous work has suggested that organisms may also respond to mutations by transcriptional adaptation, a process by which related gene(s) are upregulated independently of protein feedback loops. However, the prevalence of transcriptional adaptation and its underlying molecular mechanisms are unknown. Here, by analysing several models of transcriptional adaptation in zebrafish and mouse, we uncover a requirement for mutant mRNA degradation. Alleles that fail to transcribe the mutated gene do not exhibit transcriptional adaptation, and these alleles give rise to more severe phenotypes than alleles displaying mutant mRNA decay. Transcriptome analysis in alleles displaying mutant mRNA decay reveals the upregulation of a substantial proportion of the genes that exhibit sequence similarity with the mutated gene's mRNA, suggesting a sequence-dependent mechanism. These findings have implications for our understanding of disease-causing mutations, and will help in the design of mutant alleles with minimal transcriptional adaptation-derived compensation.

Crime prevention through environmental design (CPTED): a review and modern bibliography

Abstract: Purpose – The purpose of this paper is to critically review the core findings from recently published place‐based crime prevention research. The paper aims to critically evaluate the available evidence on the contribution of crime prevention through environmental design as a crime prevention strategy. Design/methodology/approach – Large‐scale evaluations of crime prevention through environmental design (CPTED) are reviewed with a view to clarifying current knowledge on the evidence of crime prevention through environmental design. Findings – The review concludes that there is a growing body of research that supports the assertion that crime prevention through environmental design is effective in reducing both crime and fear of crime in the community. Research limitations/implications – Although the paper may not review all the evaluations of CPTED, it nonetheless provides a detailed compilation and overview of the most significant research in the area, including an extensive and modern bibliography on the subject. Research implications will be the subject of a forthcoming paper. Practical implications – CPTED is an increasingly fashionable approach and is being implemented on a global scale. Additionally, individual components such as territoriality, surveillance, maintenance, access control, activity support and target‐hardening are being widely deployed. However, the evidence currently available is inconclusive and much criticised, which effectively prevents widespread intervention and investment by central government. The paper details the difficulties associated with demonstrating the effectiveness of CPTED. Originality/value – The paper concludes that although empirical proof has not been definitively demonstrated, there is a large and growing body of research, which supports the assertion that crime prevention through environmental design is a pragmatic and effective crime prevention tool. This review provides an extensive bibliography of contemporary crime prevention through environmental design and a follow‐up paper will discuss the future research priorities for it.

Integration and differentiation to a variable fractional order

Abstract: Interpretation and differentiation of functions to a variable order (d/dx)nf(x) is studied in two ways: 1) using the Riemann-Liouville definition, 2) using Fourier transforms Some properties and the inversion formula are obtained