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Institution

University of New Mexico

EducationAlbuquerque, New Mexico, United States
About: University of New Mexico is a education organization based out in Albuquerque, New Mexico, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 28870 authors who have published 64767 publications receiving 2578371 citations. The organization is also known as: UNM & Universitatis Novus Mexico.


Papers
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Journal ArticleDOI
TL;DR: Buprenorphines and naloxone in combination and buprenorphine alone are safe and reduce the use of opiates and the craving for opiates among opiate-addicted persons who receive these medications in an office-based setting.
Abstract: Background Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone has been proposed, but its efficacy and safety have not been well studied. Methods We conducted a multicenter, randomized, placebo-controlled trial involving 326 opiate-addicted persons who were assigned to office-based treatment with sublingual tablets consisting of buprenorphine (16 mg) in combination with naloxone (4 mg), buprenorphine alone (16 mg), or placebo given daily for four weeks. The primary outcome measures were the percentage of urine samples negative for opiates and the subjects' self-reported craving for opiates. Safety data were obtained on 461 opiate-addicted persons who participated in an open-label study of buprenorphine and naloxone (at daily doses of up to 24 mg and 6 mg, respectively) and another 11 persons who received this combination only during the trial. Results The double-blind trial was terminated early because buprenorphine and naloxone in combination and ...

543 citations

Journal ArticleDOI
TL;DR: Evidence is observed of a higher level of diversity and lower level of population structure in western South America compared to eastern South America, a relative lack of differentiation between Mesoamerican and Andean populations, and a partial agreement on a local scale between genetic similarity and the linguistic classification of populations.
Abstract: We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower genetic diversity and greater differentiation than populations from other continental regions. We observe gradients both of decreasing genetic diversity as a function of geographic distance from the Bering Strait and of decreasing genetic similarity to Siberians—signals of the southward dispersal of human populations from the northwestern tip of the Americas. We also observe evidence of: (1) a higher level of diversity and lower level of population structure in western South America compared to eastern South America, (2) a relative lack of differentiation between Mesoamerican and Andean populations, (3) a scenario in which coastal routes were easier for migrating peoples to traverse in comparison with inland routes, and (4) a partial agreement on a local scale between genetic similarity and the linguistic classification of populations. These findings offer new insights into the process of population dispersal and differentiation during the peopling of the Americas.

542 citations

Journal ArticleDOI
TL;DR: The HIPASS catalogue as mentioned in this paper is the largest uniform catalogue of H I sources compiled to date, with 4315 sources identified purely by their H I content, and the catalogue data comprise the southern region δ< + 2 ◦ of HIPASS, the first blind H I survey to cover the entire southern sky.
Abstract: The H I Parkes All-Sky Survey (HIPASS) catalogue forms the largest uniform catalogue of H I sources compiled to date, with 4315 sources identified purely by their H I content. The catalogue data comprise the southern region δ< + 2 ◦ of HIPASS, the first blind H I survey to cover the entire southern sky. The rms noise for this survey is 13 mJy beam −1 and the velocity range is −1280 to 12 700 km s −1 . Data search, verification and parametrization methods are discussed along with a description of measured quantities. Full catalogue data are made available to the astronomical community including positions, velocities, velocity widths, integrated fluxes and peak flux densities. Also available are on-sky moment maps, position‐velocity moment maps and spectra of catalogue sources. A number of local large-scale features are observed in the space distribution of sources, including the super-Galactic plane and the Local Void. Notably, large-scale structure is seen at low Galactic latitudes, a region normally obscured at optical wavelengths.

542 citations

Journal ArticleDOI
TL;DR: CT-P 13 was well tolerated, with an efficacy and safety profile comparable to that of INX up to week 30, and the PK profiles of CT-P13 and INX were equivalent in patients with active ankylosing spondylitis.
Abstract: Objectives To compare the pharmacokinetics (PK), safety and efficacy of innovator infliximab (INX) and CT-P13, a biosimilar to INX, in patients with active ankylosing spondylitis (AS). Methods Phase 1 randomised, double-blind, multicentre, multinational, parallel-group study. Patients were randomised to receive 5 mg/kg of CT-P13 (n=125) or INX (n=125). Primary endpoints were area under the concentration-time curve (AUC) at steady state and observed maximum steady state serum concentration (C max,ss ) between weeks 22 and 30. Additional PK, efficacy endpoints, including 20% and 40% improvement response according to Assessment in Ankylosing Spondylitis International Working Group criteria (ASAS20 and ASAS40), and safety outcomes were also assessed. Results Geometric mean AUC was 32 765.8 μgh/ml for CT-P13 and 31 359.3 μgh/ml for INX. Geometric mean C max,ss was 147.0 μg/ml for CT-P13 and 144.8 μg/ml for INX. The ratio of geometric means was 104.5% (90% CI 94% to 116%) for AUC and 101.5% (90% CI 95% to 109%) for C max,ss . ASAS20 and ASAS40 responses at week 30 were 70.5% and 51.8% for CT-P13 and 72.4% and 47.4% for INX, respectively. In the CT-P13 and INX groups more than one adverse event occurred in 64.8% and 63.9% of patients, infusion reactions occurred in 3.9% and 4.9%, active tuberculosis occurred in 1.6% and 0.8%, and 27.4% and 22.5% of patients tested positive for anti-drug antibodies, respectively. Conclusions The PK profiles of CT-P13 and INX were equivalent in patients with active AS. CT-P13 was well tolerated, with an efficacy and safety profile comparable to that of INX up to week 30.

542 citations

Journal ArticleDOI
TL;DR: In this article, the authors found that the more often an industry incumbent was among the first to introduce important incremental product innovations, the greater its market share in the industry, while adopting innovations that had been introduced by competitors had a small positive relationship with greater market share.
Abstract: Incremental product innovation is a critically important competitive factor in established industries. Firms in the cardiac pacemaker industry often benefit by bringing incremental innovations to market even though the new products may cannibalize the sales of existing profitable products. The more often an industry incumbent was among the first to introduce important incremental product innovations the greater its market share in the industry, while adopting innovations that had been introduced by competitors had a small positive relationship with greater market share. The greater the number of competitors that introduced similar products, the greater the market share of firms that were first to market. Greater market share, in turn, reduced the likelihood of business dissolution, while introducing important incremental innovations provided little or no reduction in the likelihood of business dissolution net of the effects of the market share that the firm achieved. The results apply most directly to industries in which buyers incur moderate switching costs.

542 citations


Authors

Showing all 29120 results

NameH-indexPapersCitations
Bruce S. McEwen2151163200638
David Miller2032573204840
Jing Wang1844046202769
Paul M. Thompson1832271146736
David A. Weitz1781038114182
David R. Williams1782034138789
John A. Rogers1771341127390
George F. Koob171935112521
John D. Minna169951106363
Carlos Bustamante161770106053
Lewis L. Lanier15955486677
Joseph Wang158128298799
John E. Morley154137797021
Fabian Walter14699983016
Michael F. Holick145767107937
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202390
2022595
20213,060
20203,048
20192,779
20182,729