University of New Mexico

About: University of New Mexico is a education organization based out in Albuquerque, New Mexico, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 28870 authors who have published 64767 publications receiving 2578371 citations. The organization is also known as: UNM & Universitatis Novus Mexico.

Self-nonself discrimination in a computer

Abstract: The problem of protecting computer systems can be viewed generally as the problem of learning to distinguish self from other. The authors describe a method for change detection which is based on the generation of T cells in the immune system. Mathematical analysis reveals computational costs of the system, and preliminary experiments illustrate how the method might be applied to the problem of computer viruses. >

Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis

Abstract: Context Antidepressant medications represent the best established treatment for major depressive disorder, but there is little evidence that they have a specific pharmacological effect relative to pill placebo for patients with less severe depression. Objective To estimate the relative benefit of medication vs placebo across a wide range of initial symptom severity in patients diagnosed with depression. Data Sources PubMed, PsycINFO, and the Cochrane Library databases were searched from January 1980 through March 2009, along with references from meta-analyses and reviews. Study Selection Randomized placebo-controlled trials of antidepressants approved by the Food and Drug Administration in the treatment of major or minor depressive disorder were selected. Studies were included if their authors provided the requisite original data, they comprised adult outpatients, they included a medication vs placebo comparison for at least 6 weeks, they did not exclude patients on the basis of a placebo washout period, and they used the Hamilton Depression Rating Scale (HDRS). Data from 6 studies (718 patients) were included. Data Extraction Individual patient-level data were obtained from study authors. Results Medication vs placebo differences varied substantially as a function of baseline severity. Among patients with HDRS scores below 23, Cohen d effect sizes for the difference between medication and placebo were estimated to be less than 0.20 (a standard definition of a small effect). Estimates of the magnitude of the superiority of medication over placebo increased with increases in baseline depression severity and crossed the threshold defined by the National Institute for Clinical Excellence for a clinically significant difference at a baseline HDRS score of 25. Conclusions The magnitude of benefit of antidepressant medication compared with placebo increases with severity of depression symptoms and may be minimal or nonexistent, on average, in patients with mild or moderate symptoms. For patients with very severe depression, the benefit of medications over placebo is substantial.

Using Community-Based Participatory Research to Address Health Disparities

Abstract: Community-based participatory research (CBPR) has emerged in the past decades as an alternative research paradigm, which integrates education and social action to improve health and reduce health disparities. More than a set of research methods, CBPR is an orientation to research that focuses on relationships between academic and community partners, with principles of colearning, mutual benefit, and long-term commitment and incorporates community theories, participation, and practices into the research efforts. As CBPR matures, tensions have become recognized that challenge the mutuality of the research relationship, including issues of power, privilege, participation, community consent, racial and/or ethnic discrimination, and the role of research in social change. This article focuses on these challenges as a dynamic and ever-changing context of the researcher-community relationship, provides examples of these paradoxes from work in tribal communities, discusses the evidence that CBPR reduces disparities, and recommends transforming the culture of academia to strengthen collaborative research relationships.

A theory of human life history evolution: Diet, intelligence, and longevity

Abstract: Human life histories as compared to those of other primates and mammals have at least four distinctive characteristics: an exceptionally long life span an extended period of juvenile dependence support of reproduction by older post-reproductive individuals and male support of reproduction through the provisioning of females and their offspring. Another distinctive feature of our species is a large brain with its associated psychological attributes: increased capacities for learning cognition and insight. In this paper the authors propose a theory that unites and organizes these observations and generates many theoretical and empirical predictions. The authors present some tests of those predictions and outline new predictions that can be tested in future research by comparative biologists archaeologists paleontologists biological anthropologists demographers geneticists and cultural anthropologists. (authors)

Synthesizing U.S. river restoration efforts

Abstract: The authors of this Policy Forum developed a comprehensive database of >37,000 river restoration projects across the United States. Such projects have increased exponentially over the past decade with more than a billion dollars spent annually since 1990. Most are intended to enhance water quality, manage riparian zones, improve in-stream habitat, allow fish passage, and stabilize stream banks. Only 10% of project records document any form of project monitoring, and little if any of this information is either appropriate or available for assessing the ecological effectiveness of restoration activities.