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Institution

University of New Mexico

EducationAlbuquerque, New Mexico, United States
About: University of New Mexico is a education organization based out in Albuquerque, New Mexico, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 28870 authors who have published 64767 publications receiving 2578371 citations. The organization is also known as: UNM & Universitatis Novus Mexico.


Papers
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Journal ArticleDOI
TL;DR: Many ecophysiological traits—considered here as all aspects of resource uptake and utilization, including biochemistry, metabolism, gas exchange, leaf structure and function, nutrient and biomass allocation, canopy structure, and growth—are likely to influence fitness and undergo adaptive evolution.
Abstract: functional diversity, which underlies variation in growth rates, productivity, population and community dynamics, and ecosystem function. The broad congruence of these variations with climatic and environmental conditions on local, regional, and global scales has fostered the concept that plant ecophysiological characteristics are well adapted to their local circumstances. For example, the repeated occurrence of plants with CAM (Crassulacean Acid Metabolism) photosynthesis and succulent leaves or stems in severely water-limited environments, and the independent evolution of these traits in numerous plant lineages, provides compelling evidence of the physiological evolution of these water-conserving traits under the influence of natural selection (Ehleringer and Monson 1993). Similarly, studies of the evolution of heavy metal tolerance confirm that natural selection may cause rapid ecophysiological evolution in just a few generations, leading to local adaptation in populations just a few meters apart (Antonovics et al. 1971). Many ecophysiological traits—considered here as all aspects of resource uptake and utilization, including biochemistry, metabolism, gas exchange, leaf structure and function, nutrient and biomass allocation, canopy structure, and growth—are likely to influence fitness and undergo adaptive evolution. Traits affecting the assimilation and use of resources such as carbon, water, and nutrients directly influence plant growth. Patterns of resource allocation to growth, reproduction, defense, and stress tolerance are also likely to be under strong selection. Phenotypic plasticity, the expression of different phenotypes by

442 citations

Journal ArticleDOI
TL;DR: The relationship between pathogen prevalence and the value people place on physical attractiveness remained strong even after potential confounds such as distance from the equator, geographical region, and average income were statistically controlled for.

442 citations

Journal ArticleDOI
TL;DR: In this paper, the authors examined the lagging behavior for heat transport in small-scale and fast-transient processes and employed the phase-lag concept to describe the special response observed in these experiments.
Abstract: This work examines the lagging behavior for heat transport in small-scale and fast-transient processes. The experimental result by Qiu et al. for the femtosecond transient response in gold films and that by Bertman and Sandiford for the temperature pulse traveling through superfluid liquid helium are re-examined with emphasis on the lagging behavior. The model employing the phase-lag concept provides as competent or even better results when describing the special response observed in these experiments.

442 citations

Journal ArticleDOI
TL;DR: The incorporation of substrate channelling into synthetic cascades is a rapidly developing concept, and recent examples of the fabrication of cascades with controlled diffusion and flux of intermediates are presented.
Abstract: Millions of years of evolution have produced biological systems capable of efficient one-pot multi-step catalysis. The underlying mechanisms that facilitate these reaction processes are increasingly providing inspiration in synthetic chemistry. Substrate channelling, where intermediates between enzymatic steps are not in equilibrium with the bulk solution, enables increased efficiencies and yields in reaction and diffusion processes. Here, we review different mechanisms of substrate channelling found in nature and provide an overview of the analytical methods used to quantify these effects. The incorporation of substrate channelling into synthetic cascades is a rapidly developing concept, and recent examples of the fabrication of cascades with controlled diffusion and flux of intermediates are presented.

442 citations

Journal ArticleDOI
02 Mar 2000-Nature
TL;DR: Estimates of the mechanical and entropic work done by the enzyme show that T7 DNA polymerase organizes two template bases in the polymerization site during each catalytic cycle, and finds a force-induced 100-fold increase in exonucleolysis above 40 pN.
Abstract: T7 DNA polymerase1,2 catalyses DNA replication in vitro at rates of more than 100 bases per second and has a 3′→5′ exonuclease (nucleotide removing) activity at a separate active site. This enzyme possesses a ‘right hand’ shape which is common to most polymerases with fingers, palm and thumb domains3,4. The rate-limiting step for replication is thought to involve a conformational change between an ‘open fingers’ state in which the active site samples nucleotides, and a ‘closed’ state in which nucleotide incorporation occurs3,5. DNA polymerase must function as a molecular motor converting chemical energy into mechanical force as it moves over the template. Here we show, using a single-molecule assay based on the differential elasticity of single-stranded and double-stranded DNA, that mechanical force is generated during the rate-limiting step and that the motor can work against a maximum template tension of ∼34 pN. Estimates of the mechanical and entropic work done by the enzyme show that T7 DNA polymerase organizes two template bases in the polymerization site during each catalytic cycle. We also find a force-induced 100-fold increase in exonucleolysis above 40 pN.

441 citations


Authors

Showing all 29120 results

NameH-indexPapersCitations
Bruce S. McEwen2151163200638
David Miller2032573204840
Jing Wang1844046202769
Paul M. Thompson1832271146736
David A. Weitz1781038114182
David R. Williams1782034138789
John A. Rogers1771341127390
George F. Koob171935112521
John D. Minna169951106363
Carlos Bustamante161770106053
Lewis L. Lanier15955486677
Joseph Wang158128298799
John E. Morley154137797021
Fabian Walter14699983016
Michael F. Holick145767107937
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202390
2022595
20213,060
20203,049
20192,779
20182,729