University of New Mexico

About: University of New Mexico is a education organization based out in Albuquerque, New Mexico, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 28870 authors who have published 64767 publications receiving 2578371 citations. The organization is also known as: UNM & Universitatis Novus Mexico.

Strategies to advance translational research into brain barriers

Abstract: There is a paucity of therapies for most neurological disorders--from rare lysosomal storage diseases to major public health concerns such as stroke and Alzheimer's disease. Advances in the targeting of drugs to the CNS are essential for the future success of neurotherapeutics; however, the delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by the blood-brain barrier, the blood-CSF barrier, or other specialised CNS barriers. These brain barriers are now recognised as a major obstacle to the treatment of most brain disorders. The challenge to deliver therapies to the CNS is formidable, and the solution will require concerted international efforts among academia, government, and industry. At a recent meeting of expert panels, essential and high-priority recommendations to propel brain barrier research forward in six topical areas were developed and these recommendations are presented here.

Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations.

Abstract: The taxonomy of the family Filoviridae (marburgviruses and ebolaviruses) has changed several times since the discovery of its members, resulting in a plethora of species and virus names and abbreviations. The current taxonomy has only been partially accepted by most laboratory virologists. Confusion likely arose for several reasons: species names that consist of several words or which (should) contain diacritical marks, the current orthographic identity of species and virus names, and the similar pronunciation of several virus abbreviations in the absence of guidance for the correct use of vernacular names. To rectify this problem, we suggest (1) to retain the current species names Reston ebolavirus, Sudan ebolavirus, and Zaire ebolavirus, but to replace the name Cote d'Ivoire ebolavirus [sic] with Tai Forest ebolavirus and Lake Victoria marburgvirus with Marburg marburgvirus; (2) to revert the virus names of the type marburgviruses and ebolaviruses to those used for decades in the field (Marburg virus instead of Lake Victoria marburgvirus and Ebola virus instead of Zaire ebolavirus); (3) to introduce names for the remaining viruses reminiscent of jargon used by laboratory virologists but nevertheless different from species names (Reston virus, Sudan virus, Tai Forest virus), and (4) to introduce distinct abbreviations for the individual viruses (RESTV for Reston virus, SUDV for Sudan virus, and TAFV for Tai Forest virus), while retaining that for Marburg virus (MARV) and reintroducing that used over decades for Ebola virus (EBOV). Paying tribute to developments in the field, we propose (a) to create a new ebolavirus species (Bundibugyo ebolavirus) for one member virus (Bundibugyo virus, BDBV); (b) to assign a second virus to the species Marburg marburgvirus (Ravn virus, RAVV) for better reflection of now available high-resolution phylogeny; and (c) to create a new tentative genus (Cuevavirus) with one tentative species (Lloviu cuevavirus) for the recently discovered Lloviu virus (LLOV). Furthermore, we explain the etymological derivation of individual names, their pronunciation, and their correct use, and we elaborate on demarcation criteria for each taxon and virus.

Performance of the ATLAS Trigger System in 2010

Abstract: Proton-proton collisions at root s = 7 TeV and heavy ion collisions at root(NN)-N-s = 2.76 TeV were produced by the LHC and recorded using the ATLAS experiment's trigger system in 2010. The LHC is designed with a maximum bunch crossing rate of 40 MHz and the ATLAS trigger system is designed to record approximately 200 of these per second. The trigger system selects events by rapidly identifying signatures of muon, electron, photon, tau lepton, jet, and B meson candidates, as well as using global event signatures, such as missing transverse energy. An overview of the ATLAS trigger system, the evolution of the system during 2010 and the performance of the trigger system components and selections based on the 2010 collision data are shown. A brief outline of plans for the trigger system in 2011 is presented.

Relative Building-Block Fitness and the Building-Block Hypothesis

Abstract: The building-block hypothesis states that the GA works well when short, low-order, highly-fit schemas recombine to form even more highly fit higher-order schemas. The ability to produce fitter and fitter partial solutions by combining building blocks is believed to be a primary source of the GA's search power, but the GA research community currently lacks precise and quantitative descriptions of how schema processing actually takes place during the typical evolution of a GA search. Another open problem is to characterize in detail the types of fitness landscapes for which crossover will be an effective operator. In this paper we first describe a class of fitness landscapes (the “Royal Road” functions) that we have designed to investigate these questions. We then present some unexpected experimental results concerning the GA's performance on simple instances of these landscapes, in which we vary the strength of reinforcement from “stepping stones”—fit intermediate-order schemas obtained by recombining fit low-order schemas. Finally, we compare the performance of the GA on these functions with that of three commonly used hill-climbing schemes, and find that one of them, “random-mutation hill-climbing”, significantly outperforms the GA on these functions.

Formation of the radio jet in M87 at 100 Schwarzschild radii from the central black hole

Abstract: Massive galaxies often are the source of well collimated jets of material that flow outwards for tens to hundreds of kiloparsecs from the regions surrounding the presumed black holes at their centres. The processes by which the jets are formed and collimated have been important problems for many years1, and observations have hitherto had insufficient spatial resolution to investigate the length scales associated with these processes2,3. Here we report observations at 43 GHz of the inner regions of the nearby active galaxy M87. The data show a remarkably broad jet having an ‘opening angle’ of ∼60° near the centre, with strong collimation of the jet occurring at ∼30–100 Schwarzschild radii (rS) from the black hole: collimation continues out to ∼1,000 rS. These results are consistent with the hypothesis that jets are formed by an accretion disk around the central black hole, which is threaded by a magnetic field4.