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Institution

University of New Mexico

EducationAlbuquerque, New Mexico, United States
About: University of New Mexico is a education organization based out in Albuquerque, New Mexico, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 28870 authors who have published 64767 publications receiving 2578371 citations. The organization is also known as: UNM & Universitatis Novus Mexico.


Papers
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Journal ArticleDOI
TL;DR: The mushroom Coprinopsis cinerea is a classic experimental model for multicellular development in fungi because it grows on defined media, completes its life cycle in 2 weeks, produces some 108 synchronized meiocytes, and can be manipulated at all stages in development by mutation and transformation.
Abstract: The mushroom Coprinopsis cinerea is a classic experimental model for multicellular development in fungi because it grows on defined media, completes its life cycle in 2 weeks, produces some 10(8) synchronized meiocytes, and can be manipulated at all stages in development by mutation and transformation. The 37-megabase genome of C. cinerea was sequenced and assembled into 13 chromosomes. Meiotic recombination rates vary greatly along the chromosomes, and retrotransposons are absent in large regions of the genome with low levels of meiotic recombination. Single-copy genes with identifiable orthologs in other basidiomycetes are predominant in low-recombination regions of the chromosome. In contrast, paralogous multicopy genes are found in the highly recombining regions, including a large family of protein kinases (FunK1) unique to multicellular fungi. Analyses of P450 and hydrophobin gene families confirmed that local gene duplications drive the expansions of paralogous copies and the expansions occur in independent lineages of Agaricomycotina fungi. Gene-expression patterns from microarrays were used to dissect the transcriptional program of dikaryon formation (mating). Several members of the FunK1 kinase family are differentially regulated during sexual morphogenesis, and coordinate regulation of adjacent duplications is rare. The genomes of C. cinerea and Laccaria bicolor, a symbiotic basidiomycete, share extensive regions of synteny. The largest syntenic blocks occur in regions with low meiotic recombination rates, no transposable elements, and tight gene spacing, where orthologous single-copy genes are overrepresented. The chromosome assembly of C. cinerea is an essential resource in understanding the evolution of multicellularity in the fungi.

399 citations

Journal ArticleDOI
01 Oct 1984-Cancer
TL;DR: Ten of 11 patients with ovarian cancer receiving cisplatin developed a distal sensory neuropathy, manifested early by decreased vibratory sensibility in toes and depressed ankle jerks and later by uncomfortable paresthesias, which may explain the cisPlatin toxicity of peripheral nerves with relative sparing of the central nervous system.
Abstract: Ten of 11 patients with ovarian cancer receiving cisplatin developed a distal sensory neuropathy, manifested early by decreased vibratory sensibility in toes and depressed ankle jerks and later by uncomfortable paresthesias. Eleven patients receiving cisplatin, 50 mg/m2 monthly (mean tstal, 580 mg/m2) were studied prospectively with monthly neurologic examinations and conduction velocity determinations of median, peroneal, and sural nerves. Early signs were decreased vibratory sensibility in toes (mean dose, 417 f 132 mg/m2 [SD]) and loss of ankle jerks (mean dose, 455 f 86 mg/m2). With continued therapy, four developed paresthesias. Strehgth was Unaffected. Sural nerve responses abruptly disappeared in six patients (mean dose, 383 +- 103 mg/m2). Other conduction velocities remain4 sormal. Electron microscopy of peripheral nerves from four patients showed axonal degeneration and secondary myelin breakdown. Platinum concentrations in three patients were similar in tumor (3.3 fig/&, sural nerves (3.5 fig/g), and spinal ganglia (3.8 pg/g), but lower in brain (0.17 fig/&. This may explain the cisplatin toxicity of peripheral nerves with relative sparing of the central nervous system. Cancer 54:1269-1275, 1984. isDiAMiNE DICHLOROPLATINU~~ (cisplatin) has been C used as a cancer chemotherapeutic agent since I 972'.2 and has shown particular efficacy against ovarian, testicular, and bladder cancer^.^ The principle side effects are nephrotoxicity, ototoxicity, nausea and vomiting, and myelos~ppression.~ Scattered reports of peripheral neuropathy associated with cisplatin therapy also have ap~eared.~-'~ The neuropathy was primarily sensory and often the initial symptoms were paresthesias in the feet.4.5.9.10.12.14.15 Mild motor involvement was present in some case^.^.^.' Although most patients improved with cessation of treatment,4,5*10.1 '*13*18 some progressed to severe di~ability.~.~ Previous nerve conduction studies have suggested greater involvement of sensory nerves than motor newes.4.5.9.10.14 Sural nerve biopsies revealed changes interpreted as destruction of myelin in five and

399 citations

Journal ArticleDOI
TL;DR: In the absence of Pb, schoepite and becquerelite are the common initial corrosion products as mentioned in this paper, and they can dissolve completely under similar geochemical conditions.

399 citations

Book
01 Aug 1995
TL;DR: In this paper, the authors compare historical antecedents of national administrative systems administration in more developed nations and less developed nations, and present some variations in administrative system administration in less-developed nations.
Abstract: Comparison in the study of public administration a focus for comparison concepts of system transformation historical antecedents of national administrative systems administration in more developed nations - general characteristics and classicadministrative systems administration in more developed nations - some variations in administrative systems administration in less developed nations bureaucratic-prominent political regimes party-prominent political regimes an overview ofbureaucracies and political systems.

399 citations

Journal ArticleDOI
TL;DR: The diameter of the nanotubes can be altered by modifying the structure of one of the porphyrin tectons, and are composed of J-aggregates that exhibit resonance light scattering.
Abstract: Porphyrin nanotubes are made by ionic self-assembly of two oppositely charged synthetic porphyrin molecules. The diameter of the nanotubes can be altered by modifying the structure of one of the porphyrin tectons. The nanotubes are photocatalytically active, mechanically responsive to light, and are composed of J-aggregates that exhibit resonance light scattering.

399 citations


Authors

Showing all 29120 results

NameH-indexPapersCitations
Bruce S. McEwen2151163200638
David Miller2032573204840
Jing Wang1844046202769
Paul M. Thompson1832271146736
David A. Weitz1781038114182
David R. Williams1782034138789
John A. Rogers1771341127390
George F. Koob171935112521
John D. Minna169951106363
Carlos Bustamante161770106053
Lewis L. Lanier15955486677
Joseph Wang158128298799
John E. Morley154137797021
Fabian Walter14699983016
Michael F. Holick145767107937
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202390
2022595
20213,060
20203,048
20192,779
20182,729