Institution
University of New Mexico
Education•Albuquerque, New Mexico, United States•
About: University of New Mexico is a education organization based out in Albuquerque, New Mexico, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 28870 authors who have published 64767 publications receiving 2578371 citations. The organization is also known as: UNM & Universitatis Novus Mexico.
Topics: Population, Poison control, Laser, Health care, Large Hadron Collider
Papers published on a yearly basis
Papers
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TL;DR: Brain sucrose uptake increased after 3 and 48 hours of reperfusion, with maximal opening at 48 hours and return to normal by 14 days, suggesting different mechanisms of injury for the biphasic BBB injury.
Abstract: Background and Purpose —Reperfusion disrupts cerebral capillaries, causing cerebral edema and hemorrhage. Middle cerebral artery occlusion (MCAO) induces the matrix-degrading metalloproteinases, but their role in capillary injury after reperfusion is unknown. Matrix metalloproteinases (MMPs) and tissue inhibitors to metalloproteinases (TIMPs) modulate capillary permeability. Therefore, we measured blood-brain barrier (BBB) permeability, brain water and electrolytes, MMPs, and TIMPs at multiple times after reperfusion.
Methods —Adult rats underwent MCAO for 2 hours by the suture method. Brain uptake of 14C-sucrose was measured from 3 hours to 14 days after reperfusion. Levels of MMPs and TIMPs were measured by zymography and reverse zymography, respectively, in contiguous tissues. Other rats had water and electrolytes measured at 3, 24, or 48 hours after reperfusion. Treatment with a synthetic MMP inhibitor, BB-1101, on BBB permeability and cerebral edema was studied.
Results —Brain sucrose uptake increased after 3 and 48 hours of reperfusion, with maximal opening at 48 hours and return to normal by 14 days. There was a correlation between the levels of gelatinase A at 3 hours and the sucrose uptake ( P <0.05). Gelatinase A (MMP-2) was maximally increased at 5 days, and TIMP-2 was highest at 5 days. Gelatinase B and TIMP-1 were maximally elevated at 48 hours. The inhibitor of gelatinase B, TIMP-1, was also increased at 48 hours. Treatment with BB-1101 reduced BBB opening at 3 hours and brain edema at 24 hours, but neither was affected at 48 hours.
Conclusions —The initial opening at 3 hours correlated with gelatinase A levels and was blocked by a synthetic MMP inhibitor. The delayed opening, which was associated with elevated levels of gelatinase B, failed to respond to the MMP inhibitor, suggesting different mechanisms of injury for the biphasic BBB injury.
831 citations
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TL;DR: This work suggests a two-stage separation process: a priori selection of a possibly overcomplete signal dictionary in which the sources are assumed to be sparsely representable, followed by unmixing the sources by exploiting the their sparse representability.
Abstract: The blind source separation problem is to extract the underlying source signals from a set of linear mixtures, where the mixing matrix is unknown. This situation is common in acoustics, radio, medical signal and image processing, hyperspectral imaging, and other areas. We suggest a two-stage separation process: a priori selection of a possibly overcomplete signal dictionary (for instance, a wavelet frame or a learned dictionary) in which the sources are assumed to be sparsely representable, followed by unmixing the sources by exploiting the their sparse representability. We consider the general case of more sources than mixtures, but also derive a more efficient algorithm in the case of a nonovercomplete dictionary and an equal numbers of sources and mixtures. Experiments with artificial signals and musical sounds demonstrate significantly better separation than other known techniques.
829 citations
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Macalester College1, Arizona State University2, University of Western Australia3, United States Forest Service4, University of Florida5, University of California, Davis6, University of New Mexico7, University of Arizona8, Charles Darwin Foundation9, University of Sheffield10, Institute of Ecosystem Studies11, University of California, Berkeley12, Rutgers University13, Stanford University14, University of South Florida15
TL;DR: Conservationists should assess organisms on environmental impact rather than on whether they are natives, argue Mark Davis and 18 other ecologists.
Abstract: Conservationists should assess organisms on environmental impact rather than on whether they are natives, argue Mark Davis and 18 other ecologists.
828 citations
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TL;DR: The general principles of the hydrogen exchange coupled to mass spectrometry method are summarized, the latest variations on the experimental protocol that probe different types of protein movements are discussed, and other recent work and improvements in the field are reviewed.
Abstract: Hydrogen exchange coupled to mass spectrometry (MS) has become a valuable analytical tool for the study of protein dynamics. By combining information about protein dynamics with more classical functional data, a more thorough understanding of protein function can be obtained. In many cases, protein dynamics are directly related to specific protein functions such as conformational changes during enzyme activation or protein movements during binding. The method is made possible because labile backbone hydrogens in a protein will exchange with deuterium atoms when the protein is placed in a D2O solution. The subsequent increase in protein mass over time is measured with high-resolution MS. The location of the deuterium incorporation is determined by monitoring deuterium incorporation in peptic fragments that are produced after the labeling reaction. In this review, we will summarize the general principles of the method, discuss the latest variations on the experimental protocol that probe different types of protein movements, and review other recent work and improvements in the field. © 2005 Wiley Periodicals, Inc.
824 citations
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TL;DR: A dynamic network of cortical-subcortical activation associated with different components of temporal information processing is illustrated, implicating these systems in attention and temporary maintenance of intervals.
Abstract: Timing is crucial to many aspects of human performance. To better understand its neural underpinnings, we used event-related fMRI to examine the time course of activation associated with different components of a time perception task. We distinguished systems associated with encoding time intervals from those related to comparing intervals and implementing a response. Activation in the basal ganglia occurred early, and was uniquely associated with encoding time intervals, whereas cerebellar activation unfolded late, suggesting an involvement in processes other than explicit timing. Early cortical activation associated with encoding of time intervals was observed in the right inferior parietal cortex and bilateral premotor cortex, implicating these systems in attention and temporary maintenance of intervals. Late activation in the right dorsolateral prefrontal cortex emerged during comparison of time intervals. Our results illustrate a dynamic network of cortical-subcortical activation associated with different components of temporal information processing.
823 citations
Authors
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Name | H-index | Papers | Citations |
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Bruce S. McEwen | 215 | 1163 | 200638 |
David Miller | 203 | 2573 | 204840 |
Jing Wang | 184 | 4046 | 202769 |
Paul M. Thompson | 183 | 2271 | 146736 |
David A. Weitz | 178 | 1038 | 114182 |
David R. Williams | 178 | 2034 | 138789 |
John A. Rogers | 177 | 1341 | 127390 |
George F. Koob | 171 | 935 | 112521 |
John D. Minna | 169 | 951 | 106363 |
Carlos Bustamante | 161 | 770 | 106053 |
Lewis L. Lanier | 159 | 554 | 86677 |
Joseph Wang | 158 | 1282 | 98799 |
John E. Morley | 154 | 1377 | 97021 |
Fabian Walter | 146 | 999 | 83016 |
Michael F. Holick | 145 | 767 | 107937 |