scispace - formally typeset
Search or ask a question
Institution

University of New Mexico

EducationAlbuquerque, New Mexico, United States
About: University of New Mexico is a education organization based out in Albuquerque, New Mexico, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 28870 authors who have published 64767 publications receiving 2578371 citations. The organization is also known as: UNM & Universitatis Novus Mexico.


Papers
More filters
Journal ArticleDOI
Derrek P. Hibar1, Jason L. Stein2, Jason L. Stein1, Miguel E. Rentería3  +341 moreInstitutions (93)
09 Apr 2015-Nature
TL;DR: In this paper, the authors conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts.
Abstract: The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270; P = 1.08 × 10(-33); 0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability in human brain development, and may help to determine mechanisms of neuropsychiatric dysfunction.

721 citations

Journal ArticleDOI
TL;DR: This paper reviewed recent progress in the understanding of the American monsoon systems and identified some of the future challenges that remain to improve warm season climate prediction, including new insights into moisture transport processes, description of the structure and variability of the South American low level jet, and resolution of the diurnal cycle of precipitation in the core monsoon regions.
Abstract: An important goal of the Climate Variability and Predictability (CLIVAR) research on the American monsoon systems is to determine the sources and limits of predictability of warm season precipitation, with emphasis on weekly to interannual time scales. This paper reviews recent progress in the understanding of the American monsoon systems and identifies some of the future challenges that remain to improve warm season climate prediction. Much of the recent progress is derived from complementary international programs in North and South America, namely, the North American Monsoon Experiment (NAME) and the Monsoon Experiment South America (MESA), with the following common objectives: 1) to understand the key components of the American monsoon systems and their variability, 2) to determine the role of these systems in the global water cycle, 3) to improve observational datasets, and 4) to improve simulation and monthly-to-seasonal prediction of the monsoons and regional water resources. Among the recent observational advances highlighted in this paper are new insights into moisture transport processes, description of the structure and variability of the South American low-level jet, and resolution of the diurnal cycle of precipitation in the core monsoon regions. NAME and MESA are also driving major efforts in model development and hydrologic applications. Incorporated into the postfield phases of these projects are assessments of atmosphere–land surface interactions and model-based climate predictability experiments. As CLIVAR research on American monsoon systems evolves, a unified view of the climatic processes modulating continental warm season precipitation is beginning to emerge.

719 citations

Journal ArticleDOI
TL;DR: A substantial body of evidence implicates prostaglandins E1 and E2 as local feedback inhibitors of T-cell activation in vitro and in vivo and results in an enhanced cellular immune response in a number of different experimental systems.

719 citations

Journal ArticleDOI
TL;DR: The relatively high concentrations (up to 35,500 ng/L) of ofloxacin found in hospital and residential effluent may be of concern due to potential genotoxic effects and development of antibiotic resistance.

714 citations

Journal ArticleDOI
TL;DR: A set of principles based on the observation that almost all life is sustained by hierarchical branching networks, which are assumed to have invariant terminal units, are space-filling and are optimised by the process of natural selection are proposed.
Abstract: Life is the most complex physical phenomenon in the Universe, manifesting an extraordinary diversity of form and function over an enormous scale from the largest animals and plants to the smallest microbes and subcellular units. Despite this many of its most fundamental and complex phenomena scale with size in a surprisingly simple fashion. For example, metabolic rate scales as the 3/4-power of mass over 27 orders of magnitude, from molecular and intracellular levels up to the largest organisms. Similarly, time-scales (such as lifespans and growth rates) and sizes (such as bacterial genome lengths, tree heights and mitochondrial densities) scale with exponents that are typically simple powers of 1/4. The universality and simplicity of these relationships suggest that fundamental universal principles underly much of the coarse-grained generic structure and organisation of living systems. We have proposed a set of principles based on the observation that almost all life is sustained by hierarchical branching networks, which we assume have invariant terminal units, are space-filling and are optimised by the process of natural selection. We show how these general constraints explain quarter power scaling and lead to a quantitative, predictive theory that captures many of the essential features of diverse biological systems. Examples considered include animal circulatory systems, plant vascular systems, growth, mitochondrial densities, and the concept of a universal molecular clock. Temperature considerations, dimensionality and the role of invariants are discussed. Criticisms and controversies associated with this approach are also addressed.

713 citations


Authors

Showing all 29120 results

NameH-indexPapersCitations
Bruce S. McEwen2151163200638
David Miller2032573204840
Jing Wang1844046202769
Paul M. Thompson1832271146736
David A. Weitz1781038114182
David R. Williams1782034138789
John A. Rogers1771341127390
George F. Koob171935112521
John D. Minna169951106363
Carlos Bustamante161770106053
Lewis L. Lanier15955486677
Joseph Wang158128298799
John E. Morley154137797021
Fabian Walter14699983016
Michael F. Holick145767107937
Network Information
Related Institutions (5)
University of California, San Diego
204.5K papers, 12.3M citations

96% related

University of Michigan
342.3K papers, 17.6M citations

96% related

University of Minnesota
257.9K papers, 11.9M citations

96% related

University of Washington
305.5K papers, 17.7M citations

96% related

University of California, Los Angeles
282.4K papers, 15.7M citations

96% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202390
2022595
20213,060
20203,048
20192,779
20182,729