University of New Mexico

About: University of New Mexico is a education organization based out in Albuquerque, New Mexico, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 28870 authors who have published 64767 publications receiving 2578371 citations. The organization is also known as: UNM & Universitatis Novus Mexico.

Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

Abstract: Disruptions of the blood-brain barrier (BBB) and edema formation both play key roles in the development of neurological dysfunction in acute and chronic cerebral ischemia. Animal studies have revealed the molecular cascades that are initiated with hypoxia/ischemia in the cells forming the neurovascular unit and that contribute to cell death. Matrix metalloproteinases cause reversible degradation of tight junction proteins early after the onset of ischemia, and a delayed secondary opening during a neuroinflammatory response occurring from 24 to 72 hours after. Cyclooxygenases are important in the delayed opening as the neuroinflammatory response progresses. An early opening of the BBB within the 3-hour therapeutic window for tissue-type plasminogen activator can allow it to enter the brain and increase the risk of hemorrhage. Chronic hypoxic hypoperfusion opens the BBB, which contributes to the cognitive changes seen with lacunar strokes and white matter injury in subcortical ischemic vascular disease. This review will describe the molecular and cellular events associated with BBB disruption and potential therapies directed toward restoring the integrity of the neurovascular unit.

Enhancement of the index of refraction via quantum coherence.

Abstract: Atoms prepared in a coherent superposition of a ground- (or excited-) state doublet can produce a large resonant index of refraction with vanishing absorption.

Control of a Desert-Grassland Transition by a Keystone Rodent Guild

Abstract: Twelve years after three species of kangaroo rats (Dipodomys spp.) were removed from plots of Chihuahuan Desert shrub habitat, density of tall perennial and annual grasses had increased approximately threefold and rodent species typical of arid grassland had colonized. These were just the most recent and drmatic in a series of changes in plants and animals caused by experimental exclusion of Dipodomys. In this ecosystem kangaroo rats are a keystone guild: through seed predation and soil disturbance they have major effects on biological diversity and biogeochemical processes.

Beyond ANOVA, basics of applied statistics

Abstract: One Sample Normal Theory Nonnormality Effect Dependence Exercises Two Samples Normal Theory Nonnormality Unequal Variances Dependence Exercises One-Way Classification Fixed Effects Normal Theory Nonnormality Unequal Variances Dependence Random Effects Normal Theory Nonnormality Unequal Variances Dependence Exercises Two-Way Classification Fixed Effects Normal Theory Nonnormality Unequal Variances Dependence Mixed Effects Normal Theory Departures from assumptions Random Effects Normal Theory Departures from Assumptions Exercises Regression Regression Model Normal Linear Model Nonlinearity Nonnormality Unequal Variances Dependence Errors-in-Variables Model Normal Theory Departures from Assumptions Exercises Ratios Normal Theory Departures from Assumptions Exercises Variances Normal Theory Nonnormality Dependence Exercises

Chemotherapy Compared with Autologous or Allogeneic Bone Marrow Transplantation in the Management of Acute Myeloid Leukemia in First Remission

Abstract: Background In young adults with acute myeloid leukemia, intensive chemotherapy during the initial remission improves the long-term outcome, but the role of bone marrow transplantation is uncertain. We compared high-dose cytarabine with autologous or allogeneic marrow transplantation during the first remission of acute myeloid leukemia. Methods Previously untreated adolescents and adults 16 to 55 years of age who had acute myeloid leukemia received standard induction chemotherapy. After complete remission had been achieved, idarubicin (two days) and cytarabine (five days) were administered. Patients with histocompatible siblings were offered allogeneic marrow transplantation, whereas the remaining patients were randomly assigned to receive a single course of high-dose cytarabine or transplantation of autologous marrow treated with perfosfamide (4-hydroperoxycyclophosphamide). Oral busulfan and intravenous cyclophosphamide were used as preparative regimens for both allogeneic and autologous marrow transplan...